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Journal Articles

Molecular Mechanism for Synergistic Anti-Leukemic Activity of Tyrosine Kinase Inhibitors and Glucocorticoids Against Ph+ALL

Meixian Huang, MD, Takeshi Inukai, MD, PhD, Keiko Kagami, BD, Masako Abe, BD, Tamao Shinohara, MD, Atsushi Watanabe, MD PhD, Koshi Akahane, MD PhD, Shinpei Somazu, MD, Hiroko Oshiro, MD PhD, Kumiko Goi, MD PhD, Yasuhiro Maeda, MD PhD, Seiichi Okabe, MD PhD, Shinya Kimura, MD, PhD, Kanji Sugita, MD, PhD

Blood (2016) 128 (22): 1059.

https://doi.org/10.1182/blood.V128.22.1059.1059

Published: 2016

Journal Articles

Lenalidomide Effectively Induces Philadelphia-Chromosome Positive ALL Cells into Apoptosis in Synergy with Tyrosine Kinase Inhibitor

Daisuke Harama, MD PhD, Minori Tamai, MD PhD, Takeshi Inukai, MD, PhD, Kumiko Goi, MD, PhD, Takashi Yahata, PhD, Kiyoshi Ando, Takumi Ito, Hiroshi Handa, MD PhD, Kanji Sugita, MD, PhD

Blood (2016) 128 (22): 1060.

https://doi.org/10.1182/blood.V128.22.1060.1060

Published: 2016

Journal Articles

Involvement of Allele-Specific Methylation of Asparagine Synthetase Gene in Asparaginase Sensitivity of BCP-ALL

Atsushi Watanabe, MD PhD, Takeshi Inukai, MD, PhD, Minori Tamai, MD PhD, Tamao Shinohara, MD, Shinpei Somazu, MD, Hiroko Oshiro, MD PhD, Koshi Akahane, MD PhD, Kumiko Goi, MD,PhD, Kunio Miyake, PhD, Kevin Urayama, PhD MPH, Kanji Sugita, MD, PhD

Blood (2016) 128 (22): 3966.

https://doi.org/10.1182/blood.V128.22.3966.3966

Published: 2016

Journal Articles

TGFβ1 Induces MLL -Rearranged Acute Lymphoblastic Leukemia into Chemoresistant Quiescence in a Coordinated Manner with FLT3 Ligand

Minori Tamai, MD,PhD, Yoshiyuki Furuichi, MD, PhD, Shin Kasai, MD, Norie Ando, MD, Kumiko Goi, MD,PhD, Takeshi Inukai, MD, PhD, Masako Abe, Keiko Kagami, Kanji Sugita, MD, PhD

Blood (2016) 128 (22): 3972.

https://doi.org/10.1182/blood.V128.22.3972.3972

Published: 2016

Journal Articles

Analysis of Copy Number Abnormalities of 86 Acute Lymphoblastic Leukemia Cell Lines Based on the Genetic Subtypes

Chihiro Tomoyasu, MD, Toshihiko Imamura, MD, Mio Yano, MD, Daisuke Asai, MD, Meixian Huang, MD, Hiroaki Goto, MD PhD, Akira Shimada, MD PhD, Takeshi Inukai, MD PhD, Kanji Sugita, MD PhD, Hajime Hosoi, MD

Blood (2015) 126 (23): 1424.

https://doi.org/10.1182/blood.V126.23.1424.1424

Published: 2015

Journal Articles

Individual Pharmacokinetic Targeting of Busulfan in Allogeneic Hematopoietic Stem Cell Transplantation Is Essential for Infants with MLL Gene-Rearranged Acute Lymphoblastic Leukemia: A Report from the JPLSG MLL03 Study

Takayuki Takachi, MD PhD, Yuki Arakawa, MD, Hiroyoshi Nakamura, PhD, Tomoyuki Watanabe, PhD, Yuki Aoki, MD PhD, Junjiro Ohshima, MD PhD, Yoshihiro Takahashi, MD PhD, Masahiro Hirayama, MD PhD, Takako Miyamura, MD PhD, Kanji Sugita, MD PhD, Katsuyoshi Koh, MD PhD, Keizo Horibe, MD PhD, Eiichi Ishii, MD PhD, Daisuke Tomizawa, MD PhD

Blood (2015) 126 (23): 1915.

https://doi.org/10.1182/blood.V126.23.1915.1915

Published: 2015

Journal Articles

HMGA2 As a Potential Molecular Target in MLL-AF4 Positive Infant Acute Lymphoblastic Leukemia

Minenori Eguchi-Ishimae, MD PhD, Mariko Eguchi, MD PhD, Zhouying Wu, Wen Ming, Hidehiko Iwabuki, Takeshi Inukai, MD PhD, Kanji Sugita, MD PhD, Eiichi Ishii, MD PhD

Blood (2014) 124 (21): 2244.

https://doi.org/10.1182/blood.V124.21.2244.2244

Published: 2014

Journal Articles

Effect of KIR Ligand Mismatched SCT for Infantile ALL with MLL gene Rearrangement: A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)

Takako Miyamura, MD, PhD, Masahiro Hirayama, MD, PhD, Kanji Sugita, MD, PhD, Tomoyuki Watanabe, PhD, Eiichi Ishii, MD, PhD, Katsuyoshi Koh, MD, PhD, Koji Kato, MD, PhD, Akiko Moriya Saito, MD, PhD, Keizo Horibe, MD, Masahito Tsurusawa, MD, PhD, Daisuke Tomizawa

Blood (2012) 120 (21): 4543.

https://doi.org/10.1182/blood.V120.21.4543.4543

Published: 2012

Journal Articles

Triggering of CD44 by Ultra-Low-Molecular-Weight Hyaluronan Induces Cell Death by Autophagy Via Endoplasmic Reticulum Stress in Acute Lymphoblastic Leukemia with MLL Gene Rearrangements

Shin Kasai, Yoshiyuki Furuichi, MD, PhD, Norie Ando, Keiko Kagami, Kumiko Goi, MD, PhD, Takeshi Inukai, MD, PhD, Kanji Sugita, MD, PhD

Blood (2012) 120 (21): 1361.

https://doi.org/10.1182/blood.V120.21.1361.1361

Published: 2012

Journal Articles

Identification of Two New DBA Genes, RPS27 and RPL27 , by Whole-Exome Sequencing in Diamond-Blackfan Anemia Patients

Blood (2012) 120 (21): 984.

https://doi.org/10.1182/blood.V120.21.984.984

Published: 2012

Journal Articles

Chemosensitivity Is Differentially Regulated by SDF-1/CXCR4 and SDF-1/CXCR7 Axes in Acute Lymphoblastic Leukemia.

Norie Ando, Yoshiyuki Furuichi, MD, PhD, Shin Kasai, Keiko Kagami, Kumiko Goi, MD, PhD, Takeshi Inukai, MD, PhD, Kanji Sugita, MD, PhD

Blood (2012) 120 (21): 2441.

https://doi.org/10.1182/blood.V120.21.2441.2441

Published: 2012

Journal Articles

PD0332991, a CDK4/6 Inhibitor, Has An Anti-Leukemic Activity Against Lymphoid Crisis of CML and Ph+ALL Even with T315I Mutation in BCR-Abl; in Vitro Analysis

Atsushi Nemoto, MD, PhD, Takeshi Inukai, MD, PhD, Koshi Akahane, MD, PhD, Hiroko Honna- Oshiro, MD, PhD, Kumiko Goi, MD, PhD, Keiko Kagami, Yasuhiro Maeda, MD, PhD, Tetsuzo Tauchi, M.D., Shinya Kimura, MD, PhD, Kanji Sugita, MD, PhD

Blood (2011) 118 (21): 1511.

https://doi.org/10.1182/blood.V118.21.1511.1511

Published: 2011

Journal Articles

JAK2 mutations and CRLF2 rearrangements in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan

Isamu Hanada, MD, Kiminori Terui, MD, PhD, Tsutomu Toki, PhD, Ko Kudo, MD, Tomohiko Sato, MD, PhD, Takuya Kamio, MD, PhD, Shinya Sasaki, MD, PhD, Yoshihiro Takahashi, MD, PhD, Yasuhide Hayashi, MD, PhD, Kanji Sugita, MD, PhD, Seiji Kojima, MD, PhD, Kenichi Koike, MD, PhD, Yoshiyuki Kosaka, MD, PhD, Masao Kobayashi, MD, PhD, Etsuro Ito, MD, PhD

Blood (2011) 118 (21): 1451.

https://doi.org/10.1182/blood.V118.21.1451.1451

Published: 2011

Journal Articles

BCR-ABL Regulates Death Receptor Expression for TNF-Related Apoptosis-Inducing Ligand (TRAIL) in Philadelphia Chromosome-Positive Leukemia

Itaru Kuroda, MD, PhD, Takeshi Inukai, MD, PhD, Xiaochun Zhang, MD, PhD, Jiro Kikuchi, Yusuke Furukawa, Atsushi Nemoto, MD, PhD, Koshi Akahane, MD, PhD, Kinuko Hirose, MD, PhD, Hiroko Honna- Oshiro, MD, PhD, Kumiko Goi, MD, PhD, Keiko Kagami, Hideo Yagita, PhD, Tetsuzo Tauchi, M.D., Yasuhiro Maeda, MD, PhD, Kanji Sugita, MD, PhD

Blood (2011) 118 (21): 2740.

https://doi.org/10.1182/blood.V118.21.2740.2740

Published: 2011

Journal Articles

PD0332991, a CDK4/6 Inhibitor, Has An Anti-Leukemic Activity Against Ph + Leukemia with T315I Mutation in Bcr-Abl; In Vivo Analysis Using Xenograft Mice Model

Satoshi Saida, MD, Itaru Kato, MD, Takeshi Inukai, MD, PhD, Atsushi Nemoto, MD, PhD, Kanji Sugita, MD, PhD, Yasuhiro Maeda, MD, PhD, Akira Niwa, MD, PhD, Ken-ichiro Watanabe, MD, PhD, Tatsutoshi Nakahata, MD, PhD, Toshio Heike, MD, PhD

Blood (2011) 118 (21): 2577.

https://doi.org/10.1182/blood.V118.21.2577.2577

Published: 2011

Journal Articles

Activation of Notch1 Signaling Suppresses Granulocytic Differentiation and Maintains a Part of Myeloid Progenitor Cells At the Immature Stage

Makoto Nakamura, MD, Lizi Wu, PhD, Satoru Kojika, MD, James D. Griffin, MD, Kanji Sugita, MD, PhD

Blood (2011) 118 (21): 2375.

https://doi.org/10.1182/blood.V118.21.2375.2375

Published: 2011

Journal Articles

Early Phase Administration of Hematopoietic Stem Cell Transplantation to Prevent Early Relapse for Infants with Acute Lymphoblastic Leukemia and MLL Gene Rearrangement; a Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) Trial MLL03

Katsuyoshi Koh, MD, Daisuke Tomizawa, MD, Akiko Moriya Saito, MD, PhD, Tomoyuki Watanabe, PhD, Atsushi Ogawa, MD, Takashi Sato, MD, Masahiro Hirayama, MD, Yoshihiro Takahashi, MD, Yutaka Saikawa, MD, PhD, Takako Miyamura, MD, Koji Kato, MD, PhD, Kanji Sugita, MD, PhD, Takeyuki Sato, MD, Tomohiko Taki, MD, PhD, Shuki Mizutani, MD, PhD, Masahito Tsurusawa, MD, Keizo Horibe, MD, Eiichi Ishii, MD, PhD

Blood (2010) 116 (21): 529.

https://doi.org/10.1182/blood.V116.21.529.529

Published: 2010

Journal Articles

Specific MLL Fusion Partners Affect the Sensitivity of Human and Murine Leukemic Cell Lines to Demethylating Agents

Atsushi Fujiki, MD, Toshihiko Imamura, MD, PhD, Hideki Yoshida, MD, Yoshifumi Hirashima, MD, Mitsuru Miyachi, MD, PhD, Shigeki Yagyu, MD, PhD, Kanji Sugita, MD, PhD, Hajime Hosoi, MD, PhD

Blood (2010) 116 (21): 2158.

https://doi.org/10.1182/blood.V116.21.2158.2158

Published: 2010

Journal Articles

RAD001, An Inhibitor of mTOR, Enhances Monocytic Differentiation Induced by ATRA through Phosphorylation of C/EBPα In AML Cell Lines

Hideki Yoshida, MD, Toshihiko Imamura, MD, PhD, Atsushi Fujiki, MD, Yoshifumi Hirashima, MD, Mitsuru Miyachi, MD, PhD, Kanji Sugita, MD, PhD, Hajime Hosoi, MD, PhD

Blood (2010) 116 (21): 2152.

https://doi.org/10.1182/blood.V116.21.2152.2152

Published: 2010

Journal Articles

Nation-Wide Survey of Relapsed Infantile Acute Lymphoblastic Leukemia In Japan: Treatment and Outcome From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) MLL03 Study.

Takako Miyamura, MD, PhD, Katsuyoshi Koh, MD, Daisuke Tomizawa, MD, Takashi Sato, MD, PhD, Koji Kato, MD, PhD, Kanji Sugita, MD, PhD, Masahiro Hirayama, MD, Atsushi Ogawa, MD, Yoshihiro Takahashi, MD, Ryosei Nishimura, MD, PhD, Hidemasa Ochiai, MD, Yuko Nomura, MD, Akiko Saito, MD, PhD, Masahito Tsurusawa, MD, PhD, Keizo Horibe, MD, PhD, Eiichi Ishii, MD, PhD

Blood (2010) 116 (21): 1025.

https://doi.org/10.1182/blood.V116.21.1025.1025

Published: 2010

NARROW

Molecular Mechanism for Synergistic Anti-Leukemic Activity of Tyrosine Kinase Inhibitors and Glucocorticoids Against Ph+ALL

Lenalidomide Effectively Induces Philadelphia-Chromosome Positive ALL Cells into Apoptosis in Synergy with Tyrosine Kinase Inhibitor

Involvement of Allele-Specific Methylation of Asparagine Synthetase Gene in Asparaginase Sensitivity of BCP-ALL

TGFβ1 Induces MLL -Rearranged Acute Lymphoblastic Leukemia into Chemoresistant Quiescence in a Coordinated Manner with FLT3 Ligand

Analysis of Copy Number Abnormalities of 86 Acute Lymphoblastic Leukemia Cell Lines Based on the Genetic Subtypes

Individual Pharmacokinetic Targeting of Busulfan in Allogeneic Hematopoietic Stem Cell Transplantation Is Essential for Infants with MLL Gene-Rearranged Acute Lymphoblastic Leukemia: A Report from the JPLSG MLL03 Study

HMGA2 As a Potential Molecular Target in MLL-AF4 Positive Infant Acute Lymphoblastic Leukemia

Effect of KIR Ligand Mismatched SCT for Infantile ALL with MLL gene Rearrangement: A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)

Triggering of CD44 by Ultra-Low-Molecular-Weight Hyaluronan Induces Cell Death by Autophagy Via Endoplasmic Reticulum Stress in Acute Lymphoblastic Leukemia with MLL Gene Rearrangements

Identification of Two New DBA Genes, RPS27 and RPL27 , by Whole-Exome Sequencing in Diamond-Blackfan Anemia Patients

Chemosensitivity Is Differentially Regulated by SDF-1/CXCR4 and SDF-1/CXCR7 Axes in Acute Lymphoblastic Leukemia.

PD0332991, a CDK4/6 Inhibitor, Has An Anti-Leukemic Activity Against Lymphoid Crisis of CML and Ph+ALL Even with T315I Mutation in BCR-Abl; in Vitro Analysis

JAK2 mutations and CRLF2 rearrangements in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan

BCR-ABL Regulates Death Receptor Expression for TNF-Related Apoptosis-Inducing Ligand (TRAIL) in Philadelphia Chromosome-Positive Leukemia

PD0332991, a CDK4/6 Inhibitor, Has An Anti-Leukemic Activity Against Ph + Leukemia with T315I Mutation in Bcr-Abl; In Vivo Analysis Using Xenograft Mice Model

Activation of Notch1 Signaling Suppresses Granulocytic Differentiation and Maintains a Part of Myeloid Progenitor Cells At the Immature Stage

Early Phase Administration of Hematopoietic Stem Cell Transplantation to Prevent Early Relapse for Infants with Acute Lymphoblastic Leukemia and MLL Gene Rearrangement; a Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) Trial MLL03

Specific MLL Fusion Partners Affect the Sensitivity of Human and Murine Leukemic Cell Lines to Demethylating Agents

RAD001, An Inhibitor of mTOR, Enhances Monocytic Differentiation Induced by ATRA through Phosphorylation of C/EBPα In AML Cell Lines

Nation-Wide Survey of Relapsed Infantile Acute Lymphoblastic Leukemia In Japan: Treatment and Outcome From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) MLL03 Study.

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American Society of Hematology

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American Society of Hematology

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