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Jun Qi, PhD
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Journal Articles

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Angela Su, Frank Ling, Camille Vaganay, Bryann Pardieu, Lina Benajiba, MD/PhD, Gaetano Sodaro, Justine Pasanisi, Kevin H Lin, BS, Justine Rutter, PhD, Christopher F. Bassil, Iléana Antony-Debre, PhD, Gabriela Alexe, PhD, Jean-François Benoist, MD, Yana Pikman, MD, Jun Qi, PhD, Herve Dombret, MD PhD, Claude Preudhomme, PharmD, PhD, Nina Fenouille, Hava M. Golan, Kimberly Stegmaier, MD, Camille Lobry, Kris C Wood, PhD, Raphael Itzykson, Alexandre Puissant, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 877.
https://doi.org/10.1182/blood-2019-131255
Published: 2019
Journal Articles

Arginine Methylation Mediated By PRMT5 Has Significant Biological and Clinical Impact in Multiple Myeloma

Annamaria Gulla, MD, Teru Hideshima, MD PhD, Giada Bianchi, MD, Mariateresa Fulciniti, PhD, Mehmet K. Samur, PhD, Yu-Tzu Tai, PhD, Jun Qi, PhD, Takeshi Harada, MD PhD, Eugenio Morelli, MD, Nicola Amodio, PhD, Ruben D. Carrasco, MD PhD, Pierosandro Tagliaferri, MD, Nikhil C. Munshi, MD, Pierfrancesco Tassone, MD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2016) 128 (22): 1140.
https://doi.org/10.1182/blood.V128.22.1140.1140
Published: 2016
Journal Articles

An Epigenetic Regulator Screen Identifies Novel Targets That Sensitize MLL -Rearranged Leukemia to DOT1L Inhibition

Chun-Wei David Chen, PhD, Christopher Delaney, BS, Haiming Xu, PhD, Richard Koche, PhD, Amaya Lujambio Goizueta, PhD, Takayuki Hoshii, PhD, Monica Cusan, MD PhD, Jonathan Chabon, BS, Daria Gianina Valerio, MD, Michael Kuehn, MD, Xi Wang, BS, Sheng Cai, MD PhD, S. Haihua Chu, PhD, Yining Kevin Chen, Justin He, Chun-Hao Huang, PhD, Zhaohui Feng, BM, BS, Andrei Krivtsov, PhD, Jun Qi, PhD, James E. Bradner, MD, Scott W. Lowe, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 571.
https://doi.org/10.1182/blood.V128.22.571.571
Published: 2016
Journal Articles

Leukemia-Specific Delivery of Mutant NOTCH1 Targeted Therapy

Giovanni Roti, MD PhD, Jun Qi, PhD, Samuel Kitara, Anthony C. Varca, Marta Sanchez-Martin, PhD, Andrew L. Kung, MD PhD, Adolfo A. Ferrando, MD PhD, James E. Bradner, MD, Kimberly Stegmaier, MD
Journal: Blood
Blood (2016) 128 (22): 889.
https://doi.org/10.1182/blood.V128.22.889.889
Published: 2016
Journal Articles

Genome-Wide Mapping Reveals BRD4 in Regulation of Tumor-Driver Genes in Cutaneous T-Cell Lymphoma

Anjali Mishra, PhD, Alex Hartlage, BS, Laura Sullivan, Leah Grinshpun, Sonya Kwiatkowski, Jun Qi, PhD, James E. Bradner, MD, Pierluigi Porcu, MD, Michael A. Caligiuri, MD
Journal: Blood
Blood (2015) 126 (23): 589.
https://doi.org/10.1182/blood.V126.23.589.589
Published: 2015
Journal Articles

Targeted Treatment of FLT3 -Overexpressing Acute Myeloid Leukemia with MiR-150 Nanoparticles Guided By Conjugated FLT3 Ligand Peptides

Xi Jiang, PhD, Jason Bugno, Chao Hu, Yang Yang, PhD, Tobias Herold, MD, Jun Qi, PhD, Ping Chen, Sandeep Gurbuxani, MBBS, PhD, Stephen Arnovitz, Bryan Ulrich, Hengyou Weng, PhD, Yungui Wang, PhD, Hao Huang, PhD, Shenglai Li, Jennifer Strong, Mary Beth Neilly, Richard A. Larson, MD, Michelle M. Le Beau, PhD, Stefan K. Bohlander, MD, Jie Jin, MD PhD, Zejuan Li, MD PhD, James E. Bradner, MD, Seungpyo Hong, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2015) 126 (23): 3784.
https://doi.org/10.1182/blood.V126.23.3784.3784
Published: 2015
Journal Articles

Eradication of Chronic Myelogenous Leukemia By Inactivation of the Polycomb Group Protein EZH2

Huafeng Xie, PhD, Cong Peng, PhD, Jun Qi, PhD, Giullia Cheloni, Partha Das, PhD, Jialiang Huang, PhD, Minh Nguyen, Shaoguang Li, MD PhD, James E. Bradner, MD, Stuart H. Orkin, MD
Journal: Blood
Blood (2014) 124 (21): 778.
https://doi.org/10.1182/blood.V124.21.778.778
Published: 2014
Journal Articles

Superior Pre-Clinical Activity of BET (Bromodomain and Extra terminal) Protein Antagonist Combined with Ibrutinib, Panobinostat or Carfilzomib Against Human Mantle Cell Lymphoma (MCL) Cells

Baohua Sun, MD PhD, Warren Fiskus, PhD, Bhavin Shah, Jun Qi, PhD, Santhana G. T. Devaraj, PhD, Swaminathan Padmanabhan Iyer, MD, Sunil Sharma, James Bradner, MD, Youli Zu, MD PhD, Kapil N. Bhalla, MD
Journal: Blood
Blood (2014) 124 (21): 918.
https://doi.org/10.1182/blood.V124.21.918.918
Published: 2014
Journal Articles

Selectively Targeting Mutated NOTCH1 with a Folate-Thapsigargin Derivative

Giovanni Roti, MD, Jun Qi, PhD, Angela Su, B.S., Antony Varca, B.S., Jon C Aster, MD PhD, James E. Bradner, Kimberly Stegmaier, MD
Journal: Blood
Blood (2014) 124 (21): 2158.
https://doi.org/10.1182/blood.V124.21.2158.2158
Published: 2014
Journal Articles

Structure-Guided Design of DOT1L Methyltransferase Inhibitors By a Novel, Label Free Assay Platform

Joanna S. Yi, MD, Alex Federation, Jun Qi, PhD, Sirano Dhe-Paganon, PhD, Michael Hadler, MSc, Xiang Xu, PhD, Anthony Varca, Roodolph St. Pierre, Scott A. Armstrong, MD PhD, James E. Bradner
Journal: Blood
Blood (2014) 124 (21): 4811.
https://doi.org/10.1182/blood.V124.21.4811.4811
Published: 2014
Journal Articles

SALL4 Is a Key Factor in HDAC Inhibitor Mediated Ex Vivo Expansion of Human Peripheral Blood Mobilized Stem/Progenitor CD34+CD90+ Cells

Hiro Tatetsu, MD PhD, Fei Wang, Chong Gao, MD PhD, Shikiko Ueno, MD PhD, Xi Tian, BS, Myriam Armant, PhD, Alex Federation, Jun Qi, PhD, James E. Bradner, Daniel G. Tenen, MD, Li Chai, MD
Journal: Blood
Blood (2014) 124 (21): 1566.
https://doi.org/10.1182/blood.V124.21.1566.1566
Published: 2014
Journal Articles

Mechanistic Role of HEXIM1 Induction in BRD4-Antagonist Mediated Growth Inhibition, Differentiation and in Vivo Lethal Activity Against Human AML Blast Progenitor Cells

Santhana G. T. Devaraj, PhD, Warren Fiskus, PhD, Bhavin Shah, Sunil Sharma, Jun Qi, PhD, Baohua Sun, MD PhD, Saikat Saha, PhD, Swaminathan Padmanabhan Iyer, MD, Youli Zu, MD PhD, James Bradner, MD, Kapil N. Bhalla, MD
Journal: Blood
Blood (2014) 124 (21): 3534.
https://doi.org/10.1182/blood.V124.21.3534.3534
Published: 2014
Journal Articles

Targeting BCL6 and Germinal Centers (GCs) in Chronic Graft-Versus-Host Disease (cGVHD) Using Direct and Epigenomic Therapies

Ryan P Flynn, Katelyn Goodman, Jun Qi, PhD, Du Jing, Angela Panoskaltsis-Mortari, PhD, Zhang Yi, Chen Dong, PhD, Xindong Liu, Kelli P A MacDonald, PhD, Geoffrey R Hill, MD, Jonathan S Serody, MD, William J Murphy, PhD, Leo Luznik, MD, Ivan Maillard, MD PhD, John Koreth, MBBS, DPhil, Corey S Cutler, MD MPH, Robert J Soiffer, MD, Joseph H. Antin, MD, Jerome Ritz, MD, Ari M Melnick, MD, James E. Bradner, MD, Bruce R. Blazar, MD
Journal: Blood
Blood (2014) 124 (21): 535.
https://doi.org/10.1182/blood.V124.21.535.535
Published: 2014
Journal Articles

Inhibition Of H3K27-Methylome As a Novel Therapeutic Strategy In Multiple Myeloma

Maria Gkotzamanidou, MD, PhD, Masood A Shammas, PhD, Jun Qi, PhD, Mehmet Kemal Samur, PhD, Teru Hideshima, MD, PhD, Meletios A. Dimopoulos, MD, Kenneth C. Anderson, MD, James E Bradner, MD, Nikhil Munshi, MD
Journal: Blood
Blood (2013) 122 (21): 3162.
https://doi.org/10.1182/blood.V122.21.3162.3162
Published: 2013
Journal Articles

Combined Therapy With BRD4 Antagonist and FLT3 Inhibitor Exerts Synergistic Activity Against Cultured and Primary AML Blast Progenitors Expressing FLT-ITD

Melissa Rodriguez, M.D., Ph.D, Warren Fiskus, Ph.D, Sunil Sharma, MD, Jun Qi, PhD, John A Valenta, M.S., Leasha J Schaub, M.S., Bhavin Shah, Santhana Devaraj, Ph.D, Swaminathan Padmanabhan Iyer, MD, James E Bradner, MD, Kapil N. Bhalla, MD
Journal: Blood
Blood (2013) 122 (21): 3821.
https://doi.org/10.1182/blood.V122.21.3821.3821
Published: 2013
Journal Articles

Combined Therapy With BRD4 Antagonist and JAK Inhibitor Is Synergistically Lethal Against Human Myeloproliferative Neoplasm (MPN) Cells

John A Valenta, M.S., Warren Fiskus, Ph.D, Taghi Manshouri, Ph.D., Sunil Sharma, MD, Jun Qi, PhD, Leasha J Schaub, M.S., Bhavin Shah, Melissa Rodriguez, M.D., Ph.D, Santhana Devaraj, Ph.D, Swaminathan Padmanabhan Iyer, MD, Srdan Verstovsek, MD, PhD, James E Bradner, MD, Kapil N. Bhalla, MD
Journal: Blood
Blood (2013) 122 (21): 2842.
https://doi.org/10.1182/blood.V122.21.2842.2842
Published: 2013
Journal Articles

Increased Expression Of IL-15 Promotes Cutaneous T-Cell Lymphomagenesis Via The Upregulation Of Histone Deacetylases: Evidence For Successful Preclinical Targeting

Anjali Mishra, Ph.D., Krista M.D. La Perle, DVM, PhD, Dipl. ACVP, Laura Sullivan, BS, Gregory H Sams, Douglas P Curphey, Kathleen McConnell, BS, Jun Qi, PhD, Henry K Wong, MD, PhD, Samuel K Kulp, PhD, Soledad Fernandez, PhD, James E Bradner, MD, Guido Marcucci, MD, Ching-Shih Chen, PhD, Pierluigi Porcu, MD, Michael A. Caligiuri, MD
Journal: Blood
Blood (2013) 122 (21): 1826.
https://doi.org/10.1182/blood.V122.21.1826.1826
Published: 2013
Journal Articles

BRD4 Antagonist and Histone Deacetylase Inhibitor: A Novel Synergistic Combination Against Human Acute Myeloid Leukemia (AML) Cells

Warren Fiskus, Ph.D, Sunil Sharma, MD, Jun Qi, PhD, John A Valenta, M.S., Leasha J Schaub, M.S., Bhavin Shah, Karissa Peth, Laxmi U.M.R. Jakkula, PhD, Melissa Rodriguez, M.D., Ph.D, Santhana Devaraj, Ph.D, Swaminathan Padmanabhan Iyer, MD, James E Bradner, MD, Kapil N. Bhalla, MD
Journal: Blood
Blood (2013) 122 (21): 485.
https://doi.org/10.1182/blood.V122.21.485.485
Published: 2013
Journal Articles

Targeting STAT5 in Leukemia Through Inhibition of Bromodomain Proteins

Suhu Liu, PhD, MD, Sarah Walker, PhD, Erik Nelson, PhD, Robert Cirulli, Michael Xiang, BS, Jun Qi, PhD, James E Bradner, MD, David Frank, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 399.
https://doi.org/10.1182/blood.V120.21.399.399
Published: 2012
Journal Articles

BET Bromodomain Inhibition Targets Both c-Myc and IL7R in Acute Lymphoblastic Leukemia

Nadja Kopp, Christopher J. Ott, PhD, Liat Bird, Ronald Paranal, Jun Qi, PhD, Teresa Bowman, Scott J. Rodig, MD, PhD, Andrew L. Kung, MD, PhD, James E. Bradner, MD, David Weinstock, MD
Journal: Blood
Blood (2012) 120 (21): 672.
https://doi.org/10.1182/blood.V120.21.672.672
Published: 2012