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Julio C. Barredo, M.D.
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Journal Articles

The NEDD8 Conjugation Pathway Inhibitor MLN4924 Activates AMPK and Induces The ER Stress/UPR-Mediated Cell Death Pathway In Acute Lymphoblastic Leukemia

Gilles M. Leclerc, Ph.D., Shuhua Zheng, B.Sc., Ronan T. Swords, MD, PhD, FRCPI, FRCPath, Guy J. Leclerc, Ph.D., Julio C. Barredo, M.D.
Journal: Blood
Blood (2013) 122 (21): 1285.
https://doi.org/10.1182/blood.V122.21.1285.1285
Published: 2013
Journal Articles

The BCR-ABL Fusion Protein Sensitizes Acute Lymphoblastic Leukemia to Apoptotic Death Induced by the Dual Glycolytic and Glycosylation Inhibitor 2-Deoxy-D-Glucose.

Guy J Leclerc, Ph.D., Jianfeng Du, Ph.D., Joanna DeSalvo, B.Sc., Gilles M. Leclerc, Ph.D., Julio C. Barredo, M.D.
Journal: Blood
Blood (2012) 120 (21): 2439.
https://doi.org/10.1182/blood.V120.21.2439.2439
Published: 2012
Journal Articles

PIM2 Upregulation Leads to Physiological Buffering of Metformin-Induced Cell Death Mediated by ER Stress/UPR in Acute Lymphoblastic Leukemia,

Gilles M. Leclerc, Ph.D., Guy J. Leclerc, Ph.D., Jeffim N. Kuznetsov, B.Sc., Julio C. Barredo, M.D.
Journal: Blood
Blood (2011) 118 (21): 3496.
https://doi.org/10.1182/blood.V118.21.3496.3496
Published: 2011
Journal Articles

Inhibition of Akt Increases the Sensitivity of Acute Lymphoblastic Leukemia (ALL) to the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG)

Jianfeng Du, Ph.D., Joanna DeSalvo, B.Sc., Antti Muranen, B.Sc., Carlos T. Moraes, Ph.D., Julio C. Barredo, M.D.
Journal: Blood
Blood (2010) 116 (21): 3254.
https://doi.org/10.1182/blood.V116.21.3254.3254
Published: 2010
Journal Articles

Mechanisms of Sensitivity of B-Precursor, T-Lineage and BCR/ABL Positive Acute Lymphoblastic Leukemia (ALL) to the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG).

Jianfeng Du, Ph.D., Joanna DeSalvo, Julio C Barredo, M.D.
Journal: Blood
Blood (2009) 114 (22): 3081.
https://doi.org/10.1182/blood.V114.22.3081.3081
Published: 2009
Journal Articles

Histone Deacetylase Inhibitors Induce FPGS mRNA Expression and Intracellular Accumulation of Long-Chain Methotrexate Polyglutamates in Childhood Acute Lymphoblastic Leukemia: Implications for Combination Therapy

Guy J Leclerc, Ph.D., Caihong Mou, M.D., Gilles M Leclerc, Ph.D., Abdul M Mian, Ph.D., Julio C Barredo, M.D.
Journal: Blood
Blood (2008) 112 (11): 2923.
https://doi.org/10.1182/blood.V112.11.2923.2923
Published: 2008
Journal Articles

Histone Deacetylase Inhibitor Induces FPGS mRNA Expression in Childhood B-Precursor and T Acute Lymphoblastic Leukemia: Implication of Combination Therapy with Methotrexate To Enhance Cytotoxicity.

Guy J. Leclerc, PhD, Julio C. Barredo, M.D.
Journal: Blood
Blood (2007) 110 (11): 864.
https://doi.org/10.1182/blood.V110.11.864.864
Published: 2007