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Journal Articles

PTK7 Is Involved in the Chemotherapy Resistance of T-Cell Acute Lymphoblastic Leukemia through Interaction with FADD-Death Domain

Hideki Goto, MD PhD, Rachel Wilkie Grantham, PhD, Motoaki Mizuuchi, Tetsuji Yamaguchi, Takanori Teshima, MD PhD, John C. Reed, MD PhD, Shu-ichi Matsuzawa, PhD

Blood (2015) 126 (23): 3701.

https://doi.org/10.1182/blood.V126.23.3701.3701

Published: 2015

Journal Articles

Chemical Biology Strategy Reveals Cell Lineage- and Cell Differentiation-Specific Small Molecule Inhibitors of NF-κB.

Hideki Goto, MD, PhD, Paul Diaz, PhD, Shu-ichi Matsuzawa, PhD, Eduard Sergienko, PhD, Steve Vasile, PhD, Thomas Chung, PhD, Carina Wimer, Michael Hedrick, PhD, Ricardo Correa, PhD, Thomas J Kipps, MD, PhD, Anthony Pinkerton, PhD, John C. Reed, MD, PhD

Blood (2012) 120 (21): 2421.

https://doi.org/10.1182/blood.V120.21.2421.2421

Published: 2012

Journal Articles

Discovery and Characterization of Chemical Inhibitors of UBC13.

Charitha Madiraju, PhD, Shu-ichi Matsuzawa, PhD, Robert Ardecky, PhD, Ian Pass, PhD, Tram Ngo, Yasuko Matsuzawa, Carina Wimer, Michael Cuddy, Paul Diaz, PhD, Correa Ricardo, PhD, Craig Tamble, PhD, Chih-Wen Shu, PhD, Anthony Pinkerton, PhD, Eduard Sergienko, PhD, Chris Hassig, PhD, Thomas Chung, PhD, John C. Reed, MD, PhD

Blood (2012) 120 (21): 2950.

https://doi.org/10.1182/blood.V120.21.2950.2950

Published: 2012

Journal Articles

Sabutoclax, a Novel Pan BCL2 Family Inhibitor, Sensitizes Dormant Blast Crisis Chronic Myeloid Leukemia Stem Cells to Dasatinib

Heather S. Leu, B.S., Daniel J Goff, PhD, Janine Low-Marchelli, PhD, Angela C Court Recart, BS, MS, Kristen M. Smith, Ph.D., Wenxue Ma, M.D., Ph.D., Anil Sadarangani, Ph.D., Alice Y. Shih, B.S., Jun Wei, Ph.D., Dayong Zhai, Ph.D., Jason Gotlib, M.D., M.S., Mark D. Minden, MD, PhD, Giovanni Martinelli, MD, Marco A. Marra, PhD, Kelly A Frazer, Ph.D., Maurizio Pellecchia, PhD, John C. Reed, MD, PhD, Catriona Jamieson, MD, PhD

Blood (2012) 120 (21): 3739.

https://doi.org/10.1182/blood.V120.21.3739.3739

Published: 2012

Journal Articles

BCL2 Splice Isoform Switching Promotes Leukemia Stem Cell Survival and Sensitivity to a Novel Pan BCL2 Inhibitor

Blood (2011) 118 (21): 2735.

https://doi.org/10.1182/blood.V118.21.2735.2735

Published: 2011

Journal Articles

Gene Risk Scores Based on Expression of 6 Genes Quanitated by Nuclease Protection Assay in Formalin Fixed Paraffin-Embedded Tissue (FFPET) Specimens From CHOP and RCHOP Treated Patients with Diffuse Large B-Cell Lymphoma (DLBCL) Predict Outcome: An ECOG and SWOG Study

Jane N. Winter, MD, Fangxin Hong, PhD, Lisa M. Rimsza, MD, Michael LeBlanc, Ph.D., Daina Variakojis, M.D., Maryla Krajewska, M.D., Thomas M. Habermann, MD, Ari Melnick, MD, James K. Weick, MD, Frederick Pollock, Ihab Botros, Ph.D., John C. Reed, MD, PhD, Richard I Fisher, MD, Brad S. Kahl, MD, Sandra J. Horning, MD, Randy D. Gascoyne, MD

Blood (2011) 118 (21): 87.

https://doi.org/10.1182/blood.V118.21.87.87

Published: 2011

Journal Articles

Targeting XIAP and ARC (apoptosis repressor with caspase recruitment domain) Overcomes Imatinib Resitance In Blast Crisis CML Cells.

Bing Carter, Ph.D., Duncan H. Mak, M.S., Wendy D. Schober, Marina Konopleva, MD, PhD, Jorge E. Cortes, MD, Hagop M. Kantarjian, MD, Erich Koller, Ziwei Huang, John C. Reed, MD, PhD, Michael Andreeff, M.D., Ph.D.

Blood (2010) 116 (21): 3415.

https://doi.org/10.1182/blood.V116.21.3415.3415

Published: 2010

Journal Articles

Increased Incidence of Therapy Related Myeloid Neoplasia (t-MN) After Initial Therapy for CLL with Fludarabine-Cyclophosphamide (FC) Vs Fludarabine (F): Long-Term Follow-up of US Intergroup Study E2997

Blood (2010) 116 (21): 924.

https://doi.org/10.1182/blood.V116.21.924.924

Published: 2010

Journal Articles

Comparison of in Vitro Apoptotic Response of Chronic Lymphocytic Leukemia (CLL) Cells to Bcl-2 Antagonist ABT-737 and IAP Antagonist BV6.

Shinichi Kitada, MD, PhD, Ryuji Yamaguchi, Ph.D., Laura Z. Rassenti, PhD, Thomas J. Kipps, MD, PhD, John C. Reed, MD, PhD

Blood (2009) 114 (22): 4386.

https://doi.org/10.1182/blood.V114.22.4386.4386

Published: 2009

Journal Articles

Simultaneous Activation of p53 and Inhibition of XIAP Enhance the Activation of Apoptosis Signaling Pathways in AML.

Bing Z. Carter, PhD, Duncan H. Mak, Wendy D. Schober, Erich Koller, PhD, Clemencia Pinilla, PhD, Lyubomir T. Vassilev, PhD, John C. Reed, MD, PhD, Michael Andreeff, MD, PhD

Blood (2008) 112 (11): 1941.

https://doi.org/10.1182/blood.V112.11.1941.1941

Published: 2008

Journal Articles

R-(−)-Gossypol (AT101) Binds to Bcl-2 Family Proteins and Induces Apoptosis in CLL.

Carlos E. Prada, MD, Januario E. Castro, MD, Dayong Zhai, PhD, Shinichi Kitada, MD, PhD, John C. Reed, MD, PhD, Thomas J. Kipps, MD, PhD

Blood (2005) 106 (11): 2978.

https://doi.org/10.1182/blood.V106.11.2978.2978

Published: 2005

Journal Articles

The Histone Deacetylase Inhibitor Depsipeptide Mediates Distinct Patterns of Histone Acetylation in Cells Overexpressing Bcl-2.

David M. Lucas, PhD, Liwen Zhang, PhD, Melanie E. Davis, PhD, Xiaodan Su, Amy Sklenar, Mark R. Parthun, PhD, Michael A. Freitas, PhD, Shinichi Kitada, PhD, John C. Reed, MD, PhD, Guido Marcucci, MD, Michael R. Grever, MD, John C. Byrd, MD

Blood (2004) 104 (11): 2802.

https://doi.org/10.1182/blood.V104.11.2802.2802

Published: 2004

Journal Articles

Small-Molecule XIAP Inhibitors Derepress Downstream Effector Caspases and Induce Apoptosis of Leukemia Cell Lines and Patient Samples.

Aaron D. Schimmer, MD, PhD, Marcela Gronda, MSc, Zhiliang Wang, PhD, Kate Welsh, PhD, Clemencia Pinilla, PhD, Michael Andreeff, MD, PhD, Wendy D. Schober, Adel Nefzi, PhD, Richard Houghten, PhD, Joseph Brandwein, MD, Mark D. Minden, MD, PhD, Andre Schuh, MD, PhD, Richard A. Wells, MD, PhD, Hans Messner, MD, PhD, John C. Reed, MD, PhD, Bing Z. Carter, PhD

Blood (2004) 104 (11): 759.

https://doi.org/10.1182/blood.V104.11.759.759

Published: 2004

Journal Articles

Critical Molecular Studies to Strategically Plan Therapy in Chronic Lymphocytic Leukemia (CLL): Correlating Cellular Proteins with Defined Prognostic Patient Subsets and Their Response to Treatment.

Shinichi Kitada, PhD, John C. Reed, MD PhD, David M. Lucas, PhD, Donna S. Neuberg, PhD, John G. Gribben, MD, Gordon W. Dewald, PhD, Ian W. Flinn, MD PhD, Martin S. Tallman, MD, John C. Byrd, MD, Michael R. Grever, MD

Blood (2004) 104 (11): 956.

https://doi.org/10.1182/blood.V104.11.956.956

Published: 2004

Journal Articles

Inhibition of XIAP Renders Newly CD40-Activated Chronic Lymphocytic Leukemia Cells Sensitive to Fas (CD95) Mediated Apoptosis.

Arnon P. Kater, MD, Frank Dicker, PhD, Massimo Mangiola, PhD, Kate Welsh, John Ostresh, PhD, Richard Houghten, PhD, John C. Reed, MD, PhD, Thomas J. Kipps, MD, PhD, Clemencia Pinilla, PhD

Blood (2004) 104 (11): 3474.

https://doi.org/10.1182/blood.V104.11.3474.3474

Published: 2004

Journal Articles

Inhibition of XIAP Enhances Specific Cytotoxic T Lymphocyte (CTL) Killing and CD20-Directed Antibody-Dependent Cellular Cytotoxicity of Chronic Lymphocytic Leukemia B Cells.

Arnon P. Kater, MD, Roman Rieger, PhD, Kate Welsh, PhD, Adel Nefzi, PhD, Richard Houghten, PhD, John C. Reed, MD. PhD, Clemencia Pinilla, PhD, Thomas J. Kipps, MD, PhD

Blood (2004) 104 (11): 3475.

https://doi.org/10.1182/blood.V104.11.3475.3475

Published: 2004

Journal Articles

BAFF Support Survival of Chronic Lymphocytic Leukemia B Cells by a Pathway Independent of Stromal Derived Factor-1α.

Mitsufumi Nishio, MD, PhD, Nobuhiro Tsukada, MD, PhD, Shinichi Kitada, MD, PhD, Junko Ohata, MD, PhD, Nathan J. Zvaifler, MD, John C. Reed, MD, PhD, Thomas J. Kipps, MD, PhD

Blood (2004) 104 (11): 1908.

https://doi.org/10.1182/blood.V104.11.1908.1908

Published: 2004

NARROW

PTK7 Is Involved in the Chemotherapy Resistance of T-Cell Acute Lymphoblastic Leukemia through Interaction with FADD-Death Domain

Chemical Biology Strategy Reveals Cell Lineage- and Cell Differentiation-Specific Small Molecule Inhibitors of NF-κB.

Discovery and Characterization of Chemical Inhibitors of UBC13.

Sabutoclax, a Novel Pan BCL2 Family Inhibitor, Sensitizes Dormant Blast Crisis Chronic Myeloid Leukemia Stem Cells to Dasatinib

BCL2 Splice Isoform Switching Promotes Leukemia Stem Cell Survival and Sensitivity to a Novel Pan BCL2 Inhibitor

Gene Risk Scores Based on Expression of 6 Genes Quanitated by Nuclease Protection Assay in Formalin Fixed Paraffin-Embedded Tissue (FFPET) Specimens From CHOP and RCHOP Treated Patients with Diffuse Large B-Cell Lymphoma (DLBCL) Predict Outcome: An ECOG and SWOG Study

Targeting XIAP and ARC (apoptosis repressor with caspase recruitment domain) Overcomes Imatinib Resitance In Blast Crisis CML Cells.

Increased Incidence of Therapy Related Myeloid Neoplasia (t-MN) After Initial Therapy for CLL with Fludarabine-Cyclophosphamide (FC) Vs Fludarabine (F): Long-Term Follow-up of US Intergroup Study E2997

Comparison of in Vitro Apoptotic Response of Chronic Lymphocytic Leukemia (CLL) Cells to Bcl-2 Antagonist ABT-737 and IAP Antagonist BV6.

Simultaneous Activation of p53 and Inhibition of XIAP Enhance the Activation of Apoptosis Signaling Pathways in AML.

R-(−)-Gossypol (AT101) Binds to Bcl-2 Family Proteins and Induces Apoptosis in CLL.

The Histone Deacetylase Inhibitor Depsipeptide Mediates Distinct Patterns of Histone Acetylation in Cells Overexpressing Bcl-2.

Small-Molecule XIAP Inhibitors Derepress Downstream Effector Caspases and Induce Apoptosis of Leukemia Cell Lines and Patient Samples.

Critical Molecular Studies to Strategically Plan Therapy in Chronic Lymphocytic Leukemia (CLL): Correlating Cellular Proteins with Defined Prognostic Patient Subsets and Their Response to Treatment.

Inhibition of XIAP Renders Newly CD40-Activated Chronic Lymphocytic Leukemia Cells Sensitive to Fas (CD95) Mediated Apoptosis.

Inhibition of XIAP Enhances Specific Cytotoxic T Lymphocyte (CTL) Killing and CD20-Directed Antibody-Dependent Cellular Cytotoxicity of Chronic Lymphocytic Leukemia B Cells.

BAFF Support Survival of Chronic Lymphocytic Leukemia B Cells by a Pathway Independent of Stromal Derived Factor-1α.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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