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João Agostinho Machado-Neto, PhD
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Journal Articles

Irs1 S57X Heterozygous Mutant Mice Display Normal Hematopoiesis and Phenotypic Features, While Homozygous Knockout Exhibit High Fetal or Postnatal Lethality

Bruna Alves Fenerich, BSc, Jaqueline Cristina Fernandes, BSc, MSc, Cleide Lúcia Araújo Silva, MSc, Juan L Coelho-Silva, BSc, MSc, Antonio Bruno Alves Silva, BSc, MSc, Natasha Peixoto Fonseca, B.Sc., M.Sc., João Agostinho Machado-Neto, PhD, Fabiola Traina, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-139422
Published: 2020
Journal Articles

Metformin Suppress Cellular and Molecular Processes Related to Maintenance and Proliferation of Myeloproliferative Neoplasm Stem Cell

Juan L Coelho-Silva, BSc, MSc, Thiago Mantello Bianco, MSc, Antonio Bruno Alves Silva, BSc, Diego Antonio Pereira-Martins, M.Sc., Natasha Peixoto Fonseca, B.Sc., M.Sc., Isabel Weinhäuser, MSc, Eduardo M Rego, MD PhD, Fernando Chahud, MD PhD, João Agostinho Machado-Neto, PhD, Lorena Lobo Figueiredo-Pontes, MD PhD, Fabiola Traina, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1682.
https://doi.org/10.1182/blood-2019-132115
Published: 2019
Journal Articles

Molecular-Based Score Inspired on Metabolic Signature Improves Prognostic Stratification for Myelodysplastic Syndrome

Juan L Coelho-Silva, BSc, MSc, Douglas R. A. Silveira, Diego A Pereira-Martins, MSc, César Alexander Ortiz Rojas, BSc, Antonio R. Lucena-Araujo, PhD, Eduardo M Rego, MD PhD, João Agostinho Machado-Neto, PhD, Israel Bendit, MD PhD, Vanderson Rocha, MD PhD, Fabiola Traina, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4257.
https://doi.org/10.1182/blood-2019-132141
Published: 2019
Journal Articles

IGF1R-IRS1/2 Signaling Pathway Is a Potential Target for FLT3-Mutated Acute Myeloid Leukemia

Juan L Coelho-Silva, BSc, MSc, Diego A Pereira-Martins, MSc, Virginia Campos Silvestrini, BSc, MSc, Eduardo M Rego, MD PhD, Vitor Marcel Faca, PhD, João Agostinho Machado-Neto, PhD, Fabiola Traina, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2689.
https://doi.org/10.1182/blood-2019-132129
Published: 2019
Journal Articles

Pharmacological IGF1R/IRS Inhibitor, NT157, Effectively Induces Apoptosis and CDKN1A Expression in Acute Lymphoblastic Leukemia Cells

Ana Paula Nunes Rodrigues Alves, M.Sc., João Agostinho Machado-Neto, PhD, Jaqueline Cristina Fernandes, B.Sc., Bruna Alves Fenerich, B.Sc., Fernanda Borges da Silva, B.Sc., Priscila Santos Scheucher, PhD, Belinda Pinto Simões, MD, PhD, Eduardo Magalhães Rego, MD, PhD, Fabiola Traina, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 3971.
https://doi.org/10.1182/blood.V128.22.3971.3971
Published: 2016
Journal Articles

Pharmacological IRS1/2 Inhibition Induces Apoptosis in BCR-ABL1 T315I mutant Cells

Renata Scopim-Ribeiro, M.Sc., João Agostinho Machado-Neto, PhD, Christopher A. Eide, Paula de Melo Campos, PhD, Priscila Santos Scheucher, PhD, Sara Teresinha Olalla Saad, MD PhD, Eduardo Magalhães Rego, MD, PhD, Cristina E. Tognon, Brian J. Druker, MD, Fabiola Traina, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 1886.
https://doi.org/10.1182/blood.V128.22.1886.1886
Published: 2016
Journal Articles

Multitarget Antileukemic Effects of Metformin in Myeloproliferative Neoplasm Cells: Inhibition of JAK2/STAT Signaling and Mitochondrial Activity

João Agostinho Machado-Neto, PhD, Bruna Alves Fenerich, B.Sc., Renata Scopim-Ribeiro, M.Sc., Carlos Roberto Porto Dechandt, B.Sc., Ana Paula Nunes Rodrigues Alves, M.Sc., Jaqueline Cristina Fernandes, B.Sc., Priscila Santos Scheucher, PhD, Belinda Pinto Simões, MD, PhD, Luciane Carla Alberici, PhD, Lorena Lôbo de Figueiredo Pontes, MD, PhD, Eduardo Magalhães Rego, MD, PhD, Fabiola Traina, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 1960.
https://doi.org/10.1182/blood.V128.22.1960.1960
Published: 2016
Journal Articles

Pharmacological IRS1/2 Inhibition Reduces Cell Viability in BCR-ABL1 Positive Cells

Renata Scopim-Ribeiro, M.Sc., João Agostinho Machado-Neto, PhD, Paula de Melo Campos, PhD, Adriana da Silva Santos Duarte, PhD, Priscila Santos Scheucher, PhD, Amélia Góes, PhD, Sara Teresinha Olalla Saad, MD, PhD, Belinda Pinto Simoes, MD, PhD, Eduardo Magalhães Rego, MD, PhD, Fabiola Traina, MD, PhD
Journal: Blood
Blood (2015) 126 (23): 2772.
https://doi.org/10.1182/blood.V126.23.2772.2772
Published: 2015
Journal Articles

ARHGAP21 Is Upregulated and Triggers the Modulation of Rho Gtpase Signaling Pathways during Megakaryocytic Differentiation

Vanessa Aline Bernusso, Mariana Lazarini, PhD, João Agostinho Machado-Neto, PhD, Karin Spat Albino Barcellos, PhD, Sara Teresinha Olalla Saad, PhD MD
Journal: Blood
Blood (2015) 126 (23): 4760.
https://doi.org/10.1182/blood.V126.23.4760.4760
Published: 2015