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Jian Xu, PhD
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Journal Articles

Elucidating Mechanisms of Acquired Resistance to IDH Inhibition By Saturation Variant Screening of Base-Edited Leukemia Cells

Junhua Lyu, Yuxuan Liu, PhD, Hui Cao, MS, Mingyi Chen, MD PhD, Yazan F. Madanat, MD, Yuannyu Zhang, PhD, Zhimin Gu, PhD, Pranita Kaphle, MS, Kathryn E. Dickerson, MD, Paul Yenerall, PhD, Rahul Kollipara, PhD, Ralf Kittler, PhD, John Minna, MD, Weina Chen, MD PhD, Stephen Chung, MD, Robert H. Collins, MD, Xin Liu, PhD, Jian Xu, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3.
https://doi.org/10.1182/blood-2020-141433
Published: 2020
Journal Articles

Fto Promotes Extramedullary Progression of Multiple Myeloma By Regulation of HSF1 through m 6 a RNA Methylation

Aoshuang Xu, MD, Jiasi Zhang, MD, Liping Zuo, MD, Jian Xu, PhD, Xuejiao Yin, MD, Qianwen Cheng, MD, Yuyang Zhang, MD, Lei Chen, PhD, Fei Zhao, PhD, Fengjuan Fan, PhD, Yu Hu, Chunyan Sun, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3063.
https://doi.org/10.1182/blood-2019-125635
Published: 2019
Journal Articles

GATA/Heme Multi-Omics Reveals a Trace Metal-Dependent Erythrocyte Developmental Mechanism

Nobuyuki Tanimura, PhD, Ruiqi Liao, PhD, Gary M Wilson, Matthew R Dent, Miao Cao, Judith N Burstyn, PhD, Peiman Hematti, MD, Xin Liu, PhD, Yuannyu Zhang, PhD, Ye Zheng, Sunduz Keles, PhD, Jian Xu, PhD, Joshua J Coon, PhD, Emery H Bresnick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 500.
https://doi.org/10.1182/blood-2018-99-115324
Published: 2018
Journal Articles

Acute Deletion of Tet2 or Tet3 Transiently Dysregulate Murine Erythropoiesis

Aishwarya Swaminathan, PhD, Daniel Hidalgo, MA, Hien Nguyen, Scott Shaffer, Maria Figueroa, Jian Xu, PhD, Merav Socolovsky, MBBS, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 11.
https://doi.org/10.1182/blood.V130.Suppl_1.11.11
Published: 2017
Journal Articles

Targeting the Epigenetic and Metabolic Vulnerabilities of Ezh2-Deficiency-Induced Myeloid Neoplasms

Zhimin Gu, PhD, Yuxuan Liu, PhD, Hui Cao, MS, Mingyi Chen, MD PhD, Yuannyu Zhang, PhD, Le Qi, Xin Liu, PhD, Kailong Li, PhD, Kathryn Dickerson, MD, Feng Cai, PhD, Weina Chen, MD PhD, Min Ni, PhD, Ralph Deberardinis, MD PhD, Jian Xu, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 380.
https://doi.org/10.1182/blood.V130.Suppl_1.380.380
Published: 2017
Journal Articles

Fetal Hemoglobin (HbF) Silencer BCL11A Acts through a Novel DNA-Motif in the Gamma-Globin Promoters, Simplifying the Model for Hemoglobin Switching

Nan Liu, PhD, Victoria V Hargreaves, PhD, Jiyoung Hong, PhD, Woojin Kim, PhD, Jesse Kurland, PhD, Qian Zhu, PhD, Falak Sher, PhD, Claudio Macias-Trevino, BS, Jill Rogers, PhD, Guo-Cheng Yuan, PhD, Daniel E. Bauer, MD PhD, Jian Xu, PhD, Martha L Bulyk, PhD, Stuart Orkin
Journal: Blood
Blood (2017) 130 (Supplement 1): 283.
https://doi.org/10.1182/blood.V130.Suppl_1.283.283
Published: 2017
Journal Articles

In Situ Capture of the Molecular Composition of Erythroid Transcriptional Enhancers

Jian Xu, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): SCI-17.
https://doi.org/10.1182/blood.V130.Suppl_1.SCI-17.SCI-17
Published: 2017
Journal Articles

Mitochondria Coordinate Intracellular Metabolism and Epigenetic Gene Regulation during Erythropoiesis

Xin Liu, PhD, Yuannyu Zhang, PhD, Min Ni, PhD, Hui Cao, M.S., Robert Signer, PhD, Dan Li, B.S., Zhimin Gu, PhD, Zeping Hu, PhD, Navdeep Chandel, Ralph DeBerardinis, MD PhD, Feng Zhou, PhD, Zhen Shao, PhD, Jian Xu, PhD
Journal: Blood
Blood (2016) 128 (22): 1038.
https://doi.org/10.1182/blood.V128.22.1038.1038
Published: 2016
Journal Articles

Quantitative Proteomic and Transcriptomic Analysis Reveals Post-Transcriptional Regulation of Mitochondrial Biogenesis during Erythropoiesis

Xin Liu, PhD, Yuannyu Zhang, PhD, Feng Zhou, PhD, Zhen Shao, PhD, Robert Signer, PhD, Hui Cao, M.S., Zeping Hu, PhD, Ralph DeBerardinis, MD PhD, Jian Xu, PhD
Journal: Blood
Blood (2015) 126 (23): 47.
https://doi.org/10.1182/blood.V126.23.47.47
Published: 2015
Journal Articles

The LRF/ZBTB7A Transcription Factor Is a BCL11A-Independent Repressor of Fetal Hemoglobin

Takeshi Masuda, PhD, Xin Wang, PhD, Manami Maeda, MD, PhD, Matthew C. Canver, B.S., Falak Sher, PhD, Alister P.W. Funnell, PhD, Chris Fisher, PhD, Maria Suciu, Gabriella E. Martyn, Laura J. Norton, Ruijia Zhu, Ryo Kurita, PhD, Yukio Nakamura, MD, PhD, Jian Xu, PhD, Douglas R. Higgs, FRS, Merlin Crossley, DPhil, Daniel E. Bauer, MD, PhD, Stuart H. Orkin, MD, Peter V. Kharchenko, PhD, Takahiro Maeda, MD, PhD
Journal: Blood
Blood (2015) 126 (23): 2.
https://doi.org/10.1182/blood.V126.23.2.2
Published: 2015
Journal Articles

Inflammatory Signaling Regulates Embryonic Hematopoietic Stem and Lymphoid Progenitor Cell Formation

Yan Li, Virginie Esain, PhD, Li Teng, Jian Xu, PhD, Isaura Frost, Wanda Kwan, PhD, Amanda D Yzaguirre, Marijke W Maijenberg, Stuart H. Orkin, MD, Kai Tan, PhD, Trista E North, PhD, Nancy A. Speck, PhD
Journal: Blood
Blood (2014) 124 (21): 2902.
https://doi.org/10.1182/blood.V124.21.2902.2902
Published: 2014
Journal Articles

Developmental Control of Polycomb Subunit Composition Mediates a Switch to Non-Canonical Functions during Hematopoiesis

Jian Xu, PhD, Zhen Shao, PhD, Dan Li, Huafeng Xie, PhD, Woojin Kim, PhD, Jialiang Huang, PhD, Luca Pinello, PhD, Kimberly Glass, PhD, Guo-Cheng Yuan, PhD, Stuart H. Orkin, MD
Journal: Blood
Blood (2014) 124 (21): 241.
https://doi.org/10.1182/blood.V124.21.241.241
Published: 2014
Journal Articles

An SCF-FBXW7 Ubiquitin Ligase Mediated Feedback Loop Facilitates GATA Factor Switching and Reinforces Commitment to Terminal Erythroid Maturation

Alireza Ghamari, Elizabeth Jaensch, Richard Giadone, Thomas E Akie, Jian Xu, PhD, Daniel Bauer, Stuart H. Orkin, MD, Alan B. Cantor
Journal: Blood
Blood (2014) 124 (21): 245.
https://doi.org/10.1182/blood.V124.21.245.245
Published: 2014
Journal Articles

Fine-Mapping and Genome Editing Reveal An Essential Erythroid Enhancer At The HbF-Associated BCL11A Locus

Daniel E. Bauer, MD, PHD, Sophia C. Kamran, MD, Samuel Lessard, BS, Jian Xu, PhD, Yuko Fujiwara, PhD, Carrie Lin, BS, Zhen Shao, PhD, Matthew C. Canver, BS, Elenoe C. Smith, PhD, Luca Pinello, PhD, Peter J. Sabo, PhD, Jeff Vierstra, BS, Richard A. Voit, BS, Guo-Cheng Yuan, PhD, Matthew H. Porteus, MD, PhD, John Stamatoyannopoulos, MD, Guillaume Lettre, PhD, Stuart H. Orkin, MD
Journal: Blood
Blood (2013) 122 (21): 437.
https://doi.org/10.1182/blood.V122.21.437.437
Published: 2013
Journal Articles

Identification Of BCL11A Structure-Function Domains For Fetal Hemoglobin Silencing

Jian Xu, PHD, Daniel E. Bauer, MD, PhD, Cong Peng, PhD, Elenoe C. Smith, PhD, Stuart H. Orkin, MD
Journal: Blood
Blood (2013) 122 (21): 435.
https://doi.org/10.1182/blood.V122.21.435.435
Published: 2013
Journal Articles

Genomic Determinants of Human Fetal and Adult Erythroid Gene Expression

Jian Xu, PhD, Zhen Shao, PhD, Kimberly Glass, PhD, Daniel E. Bauer, MD, PhD, Luca Pinello, PhD, Ben Van Handel, PhD, Serena Hou, John A. Stamatoyannopoulos, MD, Hanna K. A. Mikkola, MD, PhD, Guo-Cheng Yuan, PhD, Stuart H. Orkin, MD
Journal: Blood
Blood (2012) 120 (21): 1227.
https://doi.org/10.1182/blood.V120.21.1227.1227
Published: 2012
Journal Articles

Inability to Express HOXA Cluster and BCL11A Genes Compromises Self-Renewal and Multipotency of hESC-Derived Hematopoietic Cells

Diana R Dou, Arazin Minasian, Maria I Sierra, PhD, Pamela Saarikoski, Jian Xu, PhD, Stuart H. Orkin, MD, Sacha L. Prashad, Mattias Magnusson, PhD, Jerome A. Zack, PhD, Gay M. Crooks, MBBS, Zoran Galic, PhD, Hanna K. A. Mikkola, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1190.
https://doi.org/10.1182/blood.V120.21.1190.1190
Published: 2012
Journal Articles

Hematopoietic SIN Lentiviral Micro RNA-Mediated Silencing of BCL11A: Pre-Clinical Evidence for a Sickle Cell Disease Gene-Therapy Trial

Raffaele Renella, MD, PhD, Aleksej Perlov, Chad E Harris, Daniel E. Bauer, MD, PhD, Jian Xu, PhD, Swaroopa Guda, PhD, Michael D. Milsom, PhD, Stuart H. Orkin, MD, David A. Williams, MD
Journal: Blood
Blood (2012) 120 (21): 753.
https://doi.org/10.1182/blood.V120.21.753.753
Published: 2012
Journal Articles

HbF-Associated Genetic Variation Marks an Erythroid Regulatory Element Essential for BCL11A Transcription and Subsequent Stage-Specific Globin Expression

Daniel E. Bauer, MD, PhD, Sophia C Kamran, B.S., Jian Xu, PhD, Carrie Lin, B.S., Zhen Shao, PhD, Yuko Fujiwara, PhD, Richard A. Voit, B.S., Matthew H. Porteus, MD, PhD, John A. Stamatoyannopoulos, MD, Stuart H. Orkin, MD
Journal: Blood
Blood (2012) 120 (21): 828.
https://doi.org/10.1182/blood.V120.21.828.828
Published: 2012
Journal Articles

Correction of Murine Sickle Cell Disease Through Interference with Fetal Hemoglobin Silencing

Jian Xu, PhD, Cong Peng, PhD, Vijay G. Sankaran, MD, PhD, Stuart H. Orkin, MD
Journal: Blood
Blood (2011) 118 (21): 351.
https://doi.org/10.1182/blood.V118.21.351.351
Published: 2011