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Journal Articles

IL-2 Plus IL-15 Leads to Enhanced Ex Vivo Expansion of Human Invariant Natural Killer T Cells

Melissa Mavers, MD, Federico Simonetta, MD PhD, Alexander W. Lee, Toshihito Hirai, MD PhD, Kristina Maas-Bauer, MD, Jeanette Baker, PhD, Maite Alvarez, PhD, Mustafa Turkoz, PhD, Everett H. Meyer, MD PhD, Robert S. Negrin, MD

Blood (2017) 130 (Supplement 1): 3199.

https://doi.org/10.1182/blood.V130.Suppl_1.3199.3199

Published: 2017

Journal Articles

Treatment of Donors with Liposomal Alpha-Galactosylceramide Results in the In Vivo Expansion of Invariant Natural Killer T Cells and Reduced Incidence of Acute Graft Versus Host Disease

Toshihito Hirai, MD PhD, Federico Simonetta, MD PhD, Jeanette Baker, PhD, Kristina Maas-Bauer, MD, Musutafa Turkoz, Maite Alvarez, PhD, Melissa Mavers, MD, Robert S. Negrin, MD

Blood (2017) 130 (Supplement 1): 1896.

https://doi.org/10.1182/blood.V130.Suppl_1.1896.1896

Published: 2017

Journal Articles

Foxp3 + regulatory T Cells Maintain Bone Marrow Microenvironment for B Cell Differentiation from Hematopoietic Stem Cells

Hidekazu Nishikii, MD PhD, Antonio Pierini, MD, Yasuhisa Yokoyama, MD,PhD, Takaharu Kimura, MD PhD, Hye-Sook Kwon, PhD, Maite Alvarez, PhD, Jeanette Baker, PhD, Judith Shizuru, MD PhD, Joy Wu, MD PhD, Shigeru Chiba, MD, PhD, Robert S. Negrin, MD

Blood (2016) 128 (22): 431.

https://doi.org/10.1182/blood.V128.22.431.431

Published: 2016

Journal Articles

A Phase I Study of Donor Regulatory T Cells As Treatment for Steroid Dependent/Refractory Chronic Graft Versus Host Disease

Laura Johnston, MD, Randall Armstrong, Jeanette Baker, PhD, Bita Sahaf, Joanne Otani, Keri Tate, PhD, Cynthia Tudisco, Kevin Sheehan, PhD, Everett Meyer, MD PhD, David Miklos, MD PhD, Robert S. Negrin, MD

Blood (2016) 128 (22): 385.

https://doi.org/10.1182/blood.V128.22.385.385

Published: 2016

Journal Articles

DR3 Signaling Modulates the Function of Foxp3 + regulatory T Cells and the Severity of Acute Graft and Host Disease

Hidekazu Nishikii, MD PhD, Kim Byung-Su, Yan Chen, MD, Jeanette Baker, PhD, Antonio Pierini, MD, Maite Alvarez, PhD, Melissa Mavers, MD, Kristina Maas-Bauer, MD, Robert S. Negrin, MD

Blood (2016) 128 (22): 2148.

https://doi.org/10.1182/blood.V128.22.2148.2148

Published: 2016

Journal Articles

The Use of Monoclonal Antibody Directed Chimeric Antigen Receptors to Facilitate Conventional T Cell and Treg Control of GvHD and Tissue Tolerance in Murine Models

Antonio Pierini, MD, Bettina Iliopoulou, PhD, Heshan Peiris, PhD, Magdiel Perez Cruz, PhD, Jeanette Baker, PhD, Katie Hsu, PhD, William Strober, Ping-Ping Zheng, PhD, Tom Erkers, PhD, Aaron Ring, MD PhD, Andrea Velardi, Robert S. Negrin, MD, Seung Kim, MD PhD, Everett Meyer, MD PhD

Blood (2016) 128 (22): 3355.

https://doi.org/10.1182/blood.V128.22.3355.3355

Published: 2016

Journal Articles

Expanded CD4+Foxp3+ Regulatory T Cells through DR3 Signaling Have a Distinct Immunophenotype and Abrogate the Lethal Acute-Graft and Host Disease after Allogeneic Transplantation

Hidekazu Nishikii, MD, PhD, Byung-Su Kim, MD, Yasuhisa Yokoyama, MD,PhD, Jeanette Baker, PhD, Antonio Pierini, MD, Maite Alvarez, PhD, Yuqiong Pan, MD, PhD, Yan Chen, MD, Dominik Schneidawind, MD, Shigeru Chiba, MD, PhD, Robert Negrin, MD

Blood (2015) 126 (23): 1876.

https://doi.org/10.1182/blood.V126.23.1876.1876

Published: 2015

Journal Articles

TNF-Alpha Priming Enhances CD4 + FoxP3 + Regulatory T Cell Suppressive Function in GvHD Prevention and Treatment

Antonio Pierini, MD, Caitlin Moffett, Dominik Schneidawind, MD, Jeanette Baker, PhD, Hidekazu Nishikii, MD PhD, Yuqiong Pan, MD, PhD, Maite Alvarez, PhD, Everett Meyer, MD PhD, Robert Negrin, MD

Blood (2015) 126 (23): 1885.

https://doi.org/10.1182/blood.V126.23.1885.1885

Published: 2015

Journal Articles

Third Party Invariant Natural Killer T Cells Protect from Graft-Versus-Host Disease Lethality through Expansion of Donor CD4 + FoxP3 + Regulatory T Cells

Dominik Schneidawind, MD, Jeanette Baker, PhD, Corina Buechele, MD, Everett H. Meyer, MD PhD, Robert S. Negrin, MD

Blood (2014) 124 (21): 3825.

https://doi.org/10.1182/blood.V124.21.3825.3825

Published: 2014

Journal Articles

Loss of CD62L Expression in CD4+FoxP3+ Regulatory T Cells Following Freeze-and-Thaw Prevents Protection Against GVHD in Murine Models

Mareike Florek, MD, Dominik Schneidawind, MD, Jeanette Baker, PhD, Antonio Pierini, MD, Dennis B Leveson-Gower, PhD, Yuqiong Pan, MD, Robert S. Negrin, MD, Everett H. Meyer, MD PhD

Blood (2014) 124 (21): 2427.

https://doi.org/10.1182/blood.V124.21.2427.2427

Published: 2014

Journal Articles

CD4+FoxP3+ Regulatory T Cells Regulate B Cell Differentiation and Induce Tolerance to Bone Marrow Grafts

Antonio Pierini, MD, Hidekazu Nishikii, MD PhD, Yuqiong Pan, MD, Jeanette Baker, PhD, Dennis B Leveson-Gower, PhD, Mareike Florek, MD, Robert Negrin, MD

Blood (2014) 124 (21): 4322.

https://doi.org/10.1182/blood.V124.21.4322.4322

Published: 2014

Journal Articles

Activation of DR3 Signaling Expands Recipient Derived Regulatory T Cells and Enhances Donor Immune Reconstitution Derived from Allogeneic Hematopoietic Stem Cells

Hidekazu Nishikii, MD PhD, Byung Su Kim, MD, Antonio Pierini, MD, Jeanette Baker, PhD, Dominik Schneidawind, MD, Yuqiong Pan, MD, Maite Alvarez, PhD, Robert S. Negrin, MD

Blood (2014) 124 (21): 1087.

https://doi.org/10.1182/blood.V124.21.1087.1087

Published: 2014

Journal Articles

Donor Requirements For CD4+CD25+FoxP3+ Regulatory T Cells Capable Of Suppressing CD4+ and CD8+ Conventional T Cell Proliferation and Graft Versus Host Disease

Antonio Pierini, MD, Lucrezia Colonna, PhD, Maite Alvarez, PhD, Dominik Schneidawind, MD, Byung-Su Kim, MD, Jeanette Baker, PhD, Robert Negrin, MD

Blood (2013) 122 (21): 4484.

https://doi.org/10.1182/blood.V122.21.4484.4484

Published: 2013

Journal Articles

Adoptive Transfer Of Ex Vivo “Educated” CD4+CD25+FoxP3+ Regulatory T Cells Effectively Treats Acute Graft Versus Host Disease Preserving Graft Versus Tumor Effect

Antonio Pierini, MD, Dominik Schneidawind, MD, Mareike Florek, MD, Maite Alvarez, PhD, Yuqiong Pan, MD, Jeanette Baker, PhD, Everett Meyer, MD, PhD, Robert Negrin, MD

Blood (2013) 122 (21): 4485.

https://doi.org/10.1182/blood.V122.21.4485.4485

Published: 2013

Journal Articles

Host CD4+CD25+FoxP3+ Regulatory T Cells Facilitate Donor Engraftment Without Impacting Graft Versus Host Disease Onset After Major-Mismatched Hematopoietic Stem Cell Transplantation

Antonio Pierini, MD, Hidekazu Nishikii, MD, PhD, Mareike Florek, MD, Dennis B Leveson-Gower, PhD, Yuqiong Pan, MD, Byung-Su Kim, MD, Jeanette Baker, PhD, Robert Negrin, MD

Blood (2013) 122 (21): 1996.

https://doi.org/10.1182/blood.V122.21.1996.1996

Published: 2013

Journal Articles

Agonistic Anti-DR3 Antibody Expands Treg and Reduces Experimental Acute Graft-Versus-Host Disease

Byung-Su Kim, MD, Antonio Pierini, MD, Dominik Schneidawind, MD, Jeanette Baker, PhD, Hidekazu Nishikii, MD, PhD, Yuqiong Pan, MD, Maite Alvarez, PhD, Robert Negrin, MD

Blood (2013) 122 (21): 135.

https://doi.org/10.1182/blood.V122.21.135.135

Published: 2013

Journal Articles

CD4+ Invariant Natural Killer T Cells Require NKG2D To Protect From Lethal Acute Graft-Versus-Host Disease

Dominik Schneidawind, MD, Antonio Pierini, MD, Maite Alvarez, PhD, Yuqiong Pan, MD, Jeanette Baker, PhD, Everett Meyer, MD, PhD, Robert Negrin, MD

Blood (2013) 122 (21): 898.

https://doi.org/10.1182/blood.V122.21.898.898

Published: 2013

Journal Articles

NKT Cells Are Potent Regulators of GVHD Following Adoptive Transfer in Allogeneic BMT.

Dennis B. Leveson-Gower, PhD, Janelle A. Olson, Jeanette Baker, PhD, Robert Zeiser, MD, Andreas Beilhack, MD, Robert Negrin, MD

Blood (2007) 110 (11): 353.

https://doi.org/10.1182/blood.V110.11.353.353

Published: 2007

Journal Articles

Allogeneic Cytokine-Induced Killer Cells Traffick to GVHD Target Tissue but Cause Less GVHD, While Retaining Tumor Cytotoxicity and Facilitating Bone Marrow Engraftment.

Ryosei Nishimura, MD, PhD, Jeanette Baker, PhD, Andreas Beilhack, MD, Robert Negrin, MD

Blood (2006) 108 (11): 3169.

https://doi.org/10.1182/blood.V108.11.3169.3169

Published: 2006

Journal Articles

Immunotherapy of Primary Ovarian Cancer Using Autologous Cytokine Induced Killer Cells Retargeted with Bispecific Antibodies: A Preclinical Study.

John K. Chan, MD, Chad A. Hamilton, MD, Michael K. Cheung, BA, Mobin Karimi, MS, Jeanette Baker, PhD, Jonathan M. Gall, BA, Lawrence G. Lum, MD, Stephan Schulz, MD, Steve H. Thorne, PhD, Nelson N. Teng, MD, PhD, Christopher H. Contag, PhD, Robert S. Negrin, MD

Blood (2005) 106 (11): 2379.

https://doi.org/10.1182/blood.V106.11.2379.2379

Published: 2005

NARROW

IL-2 Plus IL-15 Leads to Enhanced Ex Vivo Expansion of Human Invariant Natural Killer T Cells

Treatment of Donors with Liposomal Alpha-Galactosylceramide Results in the In Vivo Expansion of Invariant Natural Killer T Cells and Reduced Incidence of Acute Graft Versus Host Disease

Foxp3 + regulatory T Cells Maintain Bone Marrow Microenvironment for B Cell Differentiation from Hematopoietic Stem Cells

A Phase I Study of Donor Regulatory T Cells As Treatment for Steroid Dependent/Refractory Chronic Graft Versus Host Disease

DR3 Signaling Modulates the Function of Foxp3 + regulatory T Cells and the Severity of Acute Graft and Host Disease

The Use of Monoclonal Antibody Directed Chimeric Antigen Receptors to Facilitate Conventional T Cell and Treg Control of GvHD and Tissue Tolerance in Murine Models

Expanded CD4+Foxp3+ Regulatory T Cells through DR3 Signaling Have a Distinct Immunophenotype and Abrogate the Lethal Acute-Graft and Host Disease after Allogeneic Transplantation

TNF-Alpha Priming Enhances CD4 + FoxP3 + Regulatory T Cell Suppressive Function in GvHD Prevention and Treatment

Third Party Invariant Natural Killer T Cells Protect from Graft-Versus-Host Disease Lethality through Expansion of Donor CD4 + FoxP3 + Regulatory T Cells

Loss of CD62L Expression in CD4+FoxP3+ Regulatory T Cells Following Freeze-and-Thaw Prevents Protection Against GVHD in Murine Models

CD4+FoxP3+ Regulatory T Cells Regulate B Cell Differentiation and Induce Tolerance to Bone Marrow Grafts

Activation of DR3 Signaling Expands Recipient Derived Regulatory T Cells and Enhances Donor Immune Reconstitution Derived from Allogeneic Hematopoietic Stem Cells

Donor Requirements For CD4+CD25+FoxP3+ Regulatory T Cells Capable Of Suppressing CD4+ and CD8+ Conventional T Cell Proliferation and Graft Versus Host Disease

Adoptive Transfer Of Ex Vivo “Educated” CD4+CD25+FoxP3+ Regulatory T Cells Effectively Treats Acute Graft Versus Host Disease Preserving Graft Versus Tumor Effect

Host CD4+CD25+FoxP3+ Regulatory T Cells Facilitate Donor Engraftment Without Impacting Graft Versus Host Disease Onset After Major-Mismatched Hematopoietic Stem Cell Transplantation

Agonistic Anti-DR3 Antibody Expands Treg and Reduces Experimental Acute Graft-Versus-Host Disease

CD4+ Invariant Natural Killer T Cells Require NKG2D To Protect From Lethal Acute Graft-Versus-Host Disease

NKT Cells Are Potent Regulators of GVHD Following Adoptive Transfer in Allogeneic BMT.

Allogeneic Cytokine-Induced Killer Cells Traffick to GVHD Target Tissue but Cause Less GVHD, While Retaining Tumor Cytotoxicity and Facilitating Bone Marrow Engraftment.

Immunotherapy of Primary Ovarian Cancer Using Autologous Cytokine Induced Killer Cells Retargeted with Bispecific Antibodies: A Preclinical Study.

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American Society of Hematology

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American Society of Hematology

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