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Journal Articles

Mice Deficient in Urokinase-Type Plasminogen Activator (uPA) or uPA Receptor Develop Significantly Diminished Collagen-Induced Arthritis

Sherry Thornton, PhD, Harini Raghu, PhD, Alice Jone, BS, Carolina Cruz, BS, Cheryl L. Rewerts, MS, Malinda D. Frederick, Jay L. Degen, PhD, Matthew J. Flick, PhD

Blood (2014) 124 (21): 580.

https://doi.org/10.1182/blood.V124.21.580.580

Published: 2014

Journal Articles

Diminished Multi-Organ Pathologies and Inflammation Associated With Sickle Cell Disease In Mice With Genetically Limited Prothrombin Levels

Paritha Arumugam, PhD, Eric S. Mullins, MD, Maureen A Shaw, MS, Kumar Shanmukhappa, BVSc., PhD, Anastacia Loberg, Tilat Rizvi, PhD, Janaka Wansapura, PhD, David Witte, MD, Punam Malik, MD, Jay L. Degen, PhD

Blood (2013) 122 (21): 729.

https://doi.org/10.1182/blood.V122.21.729.729

Published: 2013

Journal Articles

Fibrin Crosslinking Is Required For Retention Of Red Blood Cells In Venous Thrombi,

Maria M. Aleman, BS, James R. Byrnes, BS, Jianguo Wang, PhD, Nigel Mackman, PhD, Jay L. Degen, PhD, Matthew J Flick, PhD, Alisa S. Wolberg, PhD

Blood (2013) 122 (21): 451.

https://doi.org/10.1182/blood.V122.21.451.451

Published: 2013

Journal Articles

Plasmin(ogen) Deficiency Is Protective Against The Development Of Neuroinflammatory Pathologies and Paralysis In a Murine Model Of Multiple Sclerosis

Eric S. Mullins, MD, Maureen A Shaw, MS, Kathryn E McElhinney, Keith W. Kombrinck, MS, Jay L. Degen, PhD

Blood (2013) 122 (21): 1090.

https://doi.org/10.1182/blood.V122.21.1090.1090

Published: 2013

Journal Articles

Thrombin Inhibition Prevents Against Severe Atherosclerosis Progression in Prothrombotic Mice

Henri M.H. Spronk, PhD, Julian I Borissoff, Oliver Soehnlein, Rory Koenen, Rene van Oerle, Sylvia Heeneman, Mat J.A.P. Daemen, Charles T Esmon, PhD, Jay L. Degen, PhD, Hartmut Weiler, PhD, Joanne van Ryn, MSc, PhD, Hugo Ten Cate, MD, PhD

Blood (2012) 120 (21): 103.

https://doi.org/10.1182/blood.V120.21.103.103

Published: 2012

Journal Articles

Mice with Genetic Modifications in Prothrombin Limiting Activation Cleavage Events to Meizothrombin Survive to Adulthood, but Exhibit Alterations in Hemostasis and Thrombus Formation

Eric S. Mullins, MD, Maureen A. Shaw, M.S, Kathryn E. McElhinney, Keith W. Kombrinck, M.S., Matthew J. Flick, PhD, Alexander Brill, MD, PhD, Denisa D. Wagner, PhD, Jay L. Degen, PhD

Blood (2012) 120 (21): 496.

https://doi.org/10.1182/blood.V120.21.496.496

Published: 2012

Journal Articles

Mice with Megakaryocyte-Specific Deletion of TGF-β1 Are Partially Protected From Developing Cardiac Fibrosis and Systolic Dysfunction in a Pressure Overload Model

Alexander Meyer, Wei Wang, MD, Jay L. Degen, PhD, Barry S. Coller, MD, Jasimuddin Ahamed, PhD

Blood (2011) 118 (21): 362.

https://doi.org/10.1182/blood.V118.21.362.362

Published: 2011

Journal Articles

Thrombin Control Mechanisms and Thrombin Targets in Cancer Biology

Jay L. Degen, PhD, Joseph S. Palumbo, MD

Blood (2011) 118 (21): SCI-17.

https://doi.org/10.1182/blood.V118.21.SCI-17.SCI-17

Published: 2011

Journal Articles

Deficiency in Plasminogen Cause Decreased Vascularity in Sold Tissue Organs and Bone

Nicholas Mignemi, Heather Cole, Masato Yausa, M.D., David Gailani, MD, Jay L. Degen, PhD, Jonathan G Schoenecker, MD PhD

Blood (2011) 118 (21): 857.

https://doi.org/10.1182/blood.V118.21.857.857

Published: 2011

Journal Articles

Factor XIII Deficiency Improves Motor Function in Mice Challenged with Experimental Autoimmune Encephalomyelitis, An Established Model of Multiple Sclerosis

Eric S. Mullins, MD, Kathryn E. Talmage, Keith W. Kombrinck, Whitney M Miller, Joseph S. Palumbo, MD, Jay L. Degen, PhD

Blood (2011) 118 (21): 858.

https://doi.org/10.1182/blood.V118.21.858.858

Published: 2011

Journal Articles

Thrombin Supports Colitis and Colitis-Associated Cancer Pathogenesis

Brian K. Turpin, DO, Whitney M Miller, Eric S. Mullins, MD, Jay L. Degen, PhD, Matthew J. Flick, PhD, Brett P. Monia, PhD, Robert MacLeod, Ph.D., Alexey S Revenko, PhD, Joseph S. Palumbo, MD

Blood (2011) 118 (21): 2237.

https://doi.org/10.1182/blood.V118.21.2237.2237

Published: 2011

Journal Articles

Host Prothrombin and Fibrinogen Support S. Aureus Virulence In the Context of Acute Bacteremia

Matthew J. Flick, PhD, Xinli Du, PhD, Leslie Fausnacht, Harini Raghu, Kathryn E Talmage, Keith W Kombrinck, Elizabeth A. Blevins, Eric S. Mullins, MD, Joseph S. Palumbo, MD, Jay L. Degen, PhD

Blood (2010) 116 (21): 821.

https://doi.org/10.1182/blood.V116.21.821.821

Published: 2010

Journal Articles

Thrombin-Thrombomodulin Interactions Are An Important Determinant of Metastatic Potential

Netanel A Horowitz, MD, Elizabeth A. Blevins, Whitney M Miller, Ashely R Perry, Kathryn E Talmage, Eric S. Mullins, MD, Brett P. Monia, PhD, Jay L. Degen, PhD, Joseph S. Palumbo, MD

Blood (2010) 116 (21): 822.

https://doi.org/10.1182/blood.V116.21.822.822

Published: 2010

Journal Articles

Host Fibrinogen and the S. Aureus -Encoded Procoagulant Vwbp Are Context-Dependent Determinants of Bacterial Virulence.

Joni M Prasad, Xinli Du, MD, PhD, Eric S. Mullins, MD, Senad Divanovic, PhD, Kathryn E Talmage, Keith W Kombrinck, Alice G Cheng, Olaf Schneewind, MD, PhD, Matthew J. Flick, PhD, Jay L. Degen, PhD

Blood (2010) 116 (21): 1152.

https://doi.org/10.1182/blood.V116.21.1152.1152

Published: 2010

Journal Articles

Platelets Are the Major Source of Circulating TGF-β1 in Mice.

Jasimuddin Ahamed, PhD, Joseph S. Palumbo, MD, Jay L. Degen, PhD, Barry S. Coller, MD

Blood (2009) 114 (22): 4021.

https://doi.org/10.1182/blood.V114.22.4021.4021

Published: 2009

Journal Articles

The Virulence of S. Aureus Is Supported by Host Fibrinogen and Its Bacterial Receptor ClfA in the Context of Bacteremia.

Matthew J Flick, PhD, Xinli Du, Kathryn E. Talmage, Keith W. Kombrink, Elizabeth A. Blevins, Joseph S. Palumbo, MD, Jay L Degen, PhD

Blood (2009) 114 (22): 3188.

https://doi.org/10.1182/blood.V114.22.3188.3188

Published: 2009

Journal Articles

Transfusion Related Acute Lung Injury (TRALI) Is Ameliorated by Genetic Elimination of Fibrin(ogen) in Mice.

Eric S. Mullins, MD, Kathryn E. Talmage, Matthew Flick, PhD, Keith W. Kombrinck, Richard T Strait, MD, Jay L Degen, PhD

Blood (2009) 114 (22): 3189.

https://doi.org/10.1182/blood.V114.22.3189.3189

Published: 2009

Journal Articles

Engagement of Fibrinogen and β3 Integrin Is Required for Maintenance of Platelet Intracellular and Cell Surface P-Selectin Expression

Hong Yang, MD, Sean Lang, BSc, Zhimin Zhai, MD, Christopher M. Spring, MSc, Adili Reheman, MD, Pingguo Chen, PhD, Matthew J. Flick, PhD, Jay L. Degen, PhD, Ling Li, MSc, Walter H.A. Kahr, MD, PhD, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2008) 112 (11): 2868.

https://doi.org/10.1182/blood.V112.11.2868.2868

Published: 2008

Journal Articles

Mice Engineered To Express a Form of Thrombin Favoring Protein C Are Resistant to S. aureus -Induced Sepsis.

Matthew J. Flick, PhD, Anil K. Chauhan, PhD, Sara Welch, BS, Maureen A. Shaw, BS, Kathryn E. Talmage, BS, Eric S. Mullins, MD, Joseph S. Palumbo, MD, Sherry Thornton, PhD, Denisa D. Wagner, PhD, Jay L. Degen, PhD

Blood (2007) 110 (11): 267.

https://doi.org/10.1182/blood.V110.11.267.267

Published: 2007

Journal Articles

Factor XIII Supports Metastatic Potential through a Mechanism Coupled to Natural Killer Cell Function.

Joseph S. Palumbo, MD, Kelley A. Barney, Elizabeth A. Williams, Maureen A. Shaw, Anjali Mishra, PhD, Matthew J. Flick, PhD, Kathryn E. Talmage, Jay L. Degen, PhD

Blood (2007) 110 (11): 1753.

https://doi.org/10.1182/blood.V110.11.1753.1753

Published: 2007

NARROW

Mice Deficient in Urokinase-Type Plasminogen Activator (uPA) or uPA Receptor Develop Significantly Diminished Collagen-Induced Arthritis

Diminished Multi-Organ Pathologies and Inflammation Associated With Sickle Cell Disease In Mice With Genetically Limited Prothrombin Levels

Fibrin Crosslinking Is Required For Retention Of Red Blood Cells In Venous Thrombi,

Plasmin(ogen) Deficiency Is Protective Against The Development Of Neuroinflammatory Pathologies and Paralysis In a Murine Model Of Multiple Sclerosis

Thrombin Inhibition Prevents Against Severe Atherosclerosis Progression in Prothrombotic Mice

Mice with Genetic Modifications in Prothrombin Limiting Activation Cleavage Events to Meizothrombin Survive to Adulthood, but Exhibit Alterations in Hemostasis and Thrombus Formation

Mice with Megakaryocyte-Specific Deletion of TGF-β1 Are Partially Protected From Developing Cardiac Fibrosis and Systolic Dysfunction in a Pressure Overload Model

Thrombin Control Mechanisms and Thrombin Targets in Cancer Biology

Deficiency in Plasminogen Cause Decreased Vascularity in Sold Tissue Organs and Bone

Factor XIII Deficiency Improves Motor Function in Mice Challenged with Experimental Autoimmune Encephalomyelitis, An Established Model of Multiple Sclerosis

Thrombin Supports Colitis and Colitis-Associated Cancer Pathogenesis

Host Prothrombin and Fibrinogen Support S. Aureus Virulence In the Context of Acute Bacteremia

Thrombin-Thrombomodulin Interactions Are An Important Determinant of Metastatic Potential

Host Fibrinogen and the S. Aureus -Encoded Procoagulant Vwbp Are Context-Dependent Determinants of Bacterial Virulence.

Platelets Are the Major Source of Circulating TGF-β1 in Mice.

The Virulence of S. Aureus Is Supported by Host Fibrinogen and Its Bacterial Receptor ClfA in the Context of Bacteremia.

Transfusion Related Acute Lung Injury (TRALI) Is Ameliorated by Genetic Elimination of Fibrin(ogen) in Mice.

Engagement of Fibrinogen and β3 Integrin Is Required for Maintenance of Platelet Intracellular and Cell Surface P-Selectin Expression

Mice Engineered To Express a Form of Thrombin Favoring Protein C Are Resistant to S. aureus -Induced Sepsis.

Factor XIII Supports Metastatic Potential through a Mechanism Coupled to Natural Killer Cell Function.

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American Society of Hematology

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American Society of Hematology

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