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Journal Articles

RUNX1 Mutations Lead to a Myeloid Differentiation Block in Association with Enhanced Proliferation By Altering the RUNX1 Transcriptional Program

Mylène Gerritsen, MSc, Esther Tijchon, PhD, Guoqiang Yi, PhD, Jorren Kuster, BSc, Jan Jacob Schuringa, PhD, Joost H.A. Martens, Edo Vellenga, MD

Blood (2017) 130 (Supplement 1): 1229.

https://doi.org/10.1182/blood.V130.Suppl_1.1229.1229

Published: 2017

Journal Articles

Putative Autophagy Protein VMP1 Amplifies Protective Autophagy Under Stress Conditions in AML Cells

Hendrik Folkerts, MSc, Albertus T.J. Wierenga, PhD, Jan Jacob Schuringa, PhD, Edo Vellenga, MD

Blood (2017) 130 (Supplement 1): 3918.

https://doi.org/10.1182/blood.V130.Suppl_1.3918.3918

Published: 2017

Journal Articles

RUNX1 Mutations Cause a Myeloid Differentiation Block Leading to the Formation of a Long Term Expanding CD34 + /CD33 + /CD45RA + /CD123 + Cell Population

Myléne Gerritsen, MSc, Esther Tijchon, PhD, Amit Mandoli, PhD, Joost H.A. Martens, Jan Jacob Schuringa, PhD, Edo Vellenga, MD PhD

Blood (2016) 128 (22): 1979.

https://doi.org/10.1182/blood.V128.22.1979.1979

Published: 2016

Journal Articles

Blocking the Autophagy Pathway As Potential Target for the Treatment of Wild Type P53 AMLs

Hendrik Folkerts, MSc, Susan Hilgendorf, MSc, Albertus T. Wierenga, PhD, Paul J. Coffer, PhD, Jan Jacob Schuringa, PhD, Edo Vellenga, MD PhD

Blood (2016) 128 (22): 770.

https://doi.org/10.1182/blood.V128.22.770.770

Published: 2016

Journal Articles

Following Autologous Stem Cell Transplantation (1 Yr) Mesenchymal Stem Cells Are Functionally Impaired with Reduced Hematopoietic Support

Catharina Hazenberg, MD, Fiona A.J. van den Heuvel, Edo Vellenga, MD PhD, Annet Z. Brouwers-Vos, Gerbrig Berger, BSc, Jan Jacob Schuringa, PhD

Blood (2016) 128 (22): 3888.

https://doi.org/10.1182/blood.V128.22.3888.3888

Published: 2016

Journal Articles

Targeting Autophagy As a Potential Therapeutic Strategy for the Treatment of AML

Hendrik Folkerts, MSc, Bart-Jan A.T.J. Wierenga, PhD, Paul J. Coffer, PhD, Jan Jacob Schuringa, PhD, Edo Vellenga, MD PhD

Blood (2015) 126 (23): 3831.

https://doi.org/10.1182/blood.V126.23.3831.3831

Published: 2015

Journal Articles

CITED2 Cooperates with Low PU.1 and DNMT3A to Maintain Self-Renewal in Hematopoietic Stem Cells

Hein Schepers, PhD, Patrick Korthuis, MSc, Marjan Geugien, MSc, Jennifer Jaques, MSc, Tihomira I. Todorova, MSc, Ulrich Steidl, MD PhD, Jan Jacob Schuringa, PhD, Edo Vellenga, MD PhD

Blood (2015) 126 (23): 309.

https://doi.org/10.1182/blood.V126.23.309.309

Published: 2015

Journal Articles

Loss of ASXL1 Triggers an Apoptotic Response in Human Hematopoietic Stem and Progenitor Cells

Susan Hilgendorf, MSc, Hendrik Folkerts, MSc, Jan Jacob Schuringa, PhD, Edo Vellenga, MD PhD

Blood (2015) 126 (23): 4107.

https://doi.org/10.1182/blood.V126.23.4107.4107

Published: 2015

Journal Articles

Establishing Human Niche Xenograft Models for Myeloid and Lymphoid Leukemia Driven By MLL-AF9

Marco Carretta, MSc, Jennifer Jaques, Bauke de Boer, MSc, Huipin Yuan, PhD, Anton C. Martens, PhD, Edo Vellenga, MDPhD, Richard W.J. Groen, PhD, Jan Jacob Schuringa, PhD

Blood (2014) 124 (21): 4781.

https://doi.org/10.1182/blood.V124.21.4781.4781

Published: 2014

Journal Articles

Loss of ASXL1 Triggers an Apoptotic Response in Human Hematopoetic Stem and Progenitor Cells

Susan Hilgendorf, Hendrik Folkerts, Jan Jacob Schuringa, PhD, Edo Vellenga, MD PhD

Blood (2014) 124 (21): 4619.

https://doi.org/10.1182/blood.V124.21.4619.4619

Published: 2014

Journal Articles

ATG5 and ATG7 Fulfill Essential and Non-Redundant Roles in Human Hematopoietic Stem/Progenitor Cells

Hendrik Folkerts, Maria Catalina Gomez Puerto, Albertus T.J. Wierenga, PhD, Koen Schepers, PhD, Jan Jacob Schuringa, PhD, Paul J. Coffer, PhD BA, Edo Vellenga, MD PhD

Blood (2014) 124 (21): 4316.

https://doi.org/10.1182/blood.V124.21.4316.4316

Published: 2014

Journal Articles

Mesenchymal Stem Cells from Patients 1 Year Following Autologous Stem Cell Transplantation Have a Pro-Inflammatory and Senescent Phenotype Compromising the Support of Hematopoietic Stem Cells

Carin L.E. Hazenberg, MD, Fiona A.J. van den Heuvel, Ben N.G. Giepmans, PhD, Jan Jacob Schuringa, PhD, Edo Vellenga, MD PhD

Blood (2014) 124 (21): 4368.

https://doi.org/10.1182/blood.V124.21.4368.4368

Published: 2014

Journal Articles

Differential Localization Of RAC1 and RAC2 Reflects Their Specific Functions In Normal and Leukemic Human Hematopoietic Stem/Progenitor Cells

Marta Ewa Capala, MD, Francesco Bonardi, PhD, Henny Maat, Edo Vellenga, MD, PhD, Jan Jacob Schuringa, PhD

Blood (2013) 122 (21): 2892.

https://doi.org/10.1182/blood.V122.21.2892.2892

Published: 2013

Journal Articles

Decreased PU.1 and Enhanced CITED2 Cooperate To Maintain Self-Renewal In Hematopoietic Stem/Progenitors

Hein Schepers, PhD, Patrick M. Korthuis, BSc, Jan Jacob Schuringa, PhD, Edo Vellenga, MD, PhD

Blood (2013) 122 (21): 2411.

https://doi.org/10.1182/blood.V122.21.2411.2411

Published: 2013

Journal Articles

Convergence Of Hypoxia and TGFβ Pathways On Cell Cycle Regulation In Human Hematopoietic Stem/Progenitor Cells

Albertus T.J. Wierenga, PhD, Edo Vellenga, MD, PhD, Jan Jacob Schuringa, PhD

Blood (2013) 122 (21): 3694.

https://doi.org/10.1182/blood.V122.21.3694.3694

Published: 2013

Journal Articles

Establishing Human Niche Xenograft Models For Myeloid and Lymphoid Leukemia Driven By MLL-AF9

Marco Carretta, Jennifer Jaques, Yuan Huipin, Anton Martens, PhD, Edo Vellenga, MD, PhD, Richard Groen, Jan Jacob Schuringa, PhD

Blood (2013) 122 (21): 1646.

https://doi.org/10.1182/blood.V122.21.1646.1646

Published: 2013

Journal Articles

Mouse Versus Human Extrinsic Cues Dictate Transformation Potential In BCR-ABL/BMI1-Induced Leukemia In Humanized Xenograft Models

Pallavi Sontakke, Richard W.J. Groen, PhD, Jennifer Jaques, Huipin Yuan, PhD, Anton Martens, PhD, Edo Vellenga, MD, PhD, Jan Jacob Schuringa, PhD

Blood (2013) 122 (21): 515.

https://doi.org/10.1182/blood.V122.21.515.515

Published: 2013

Journal Articles

Autologous Stem Cell Transplantation Induces a Phenotypical Shift From CMP to GMP Progenitors, Reduces Clonogenic Potential and Enhances in Vitro and In Vivo Cycling Activity Defined by 18 f-FLT PET Scan.

Carolien M. Woolthuis, Ali Agool, Annet Z. Vos, Riemert H.J.A. Slart, MD, PhD, Geert A. Huls, MD, PhD, W. Martin Smid, MD, PhD, Jan Jacob Schuringa, PhD, Edo Vellenga, MD, PhD

Blood (2009) 114 (22): 4473.

https://doi.org/10.1182/blood.V114.22.4473.4473

Published: 2009

Journal Articles

The Polycomb Gene BMI1 Collaborates with BCR-ABL in Leukemic Transformation of Human Cord Blood CD34+ Cells.

Aleksandra Rizo, Sandra Olthof, OS van Ronald, PhD, Bert HJ Dontje, Edo Vellenga, MD, PhD, Gerald Haan, PhD, Jan Jacob Schuringa, PhD

Blood (2008) 112 (11): 1350.

https://doi.org/10.1182/blood.V112.11.1350.1350

Published: 2008

Journal Articles

Transcription Factor Dosage: Maximal STAT5-Induced Proliferation and Stem Cell Self-Renewal at Intermediate STAT5 Activity Levels.

Albertus T.J. Wierenga, Bsc, Edo Vellenga, MD, PhD, Jan Jacob Schuringa, PhD

Blood (2007) 110 (11): 2242.

https://doi.org/10.1182/blood.V110.11.2242.2242

Published: 2007

NARROW

RUNX1 Mutations Lead to a Myeloid Differentiation Block in Association with Enhanced Proliferation By Altering the RUNX1 Transcriptional Program

Putative Autophagy Protein VMP1 Amplifies Protective Autophagy Under Stress Conditions in AML Cells

RUNX1 Mutations Cause a Myeloid Differentiation Block Leading to the Formation of a Long Term Expanding CD34 + /CD33 + /CD45RA + /CD123 + Cell Population

Blocking the Autophagy Pathway As Potential Target for the Treatment of Wild Type P53 AMLs

Following Autologous Stem Cell Transplantation (1 Yr) Mesenchymal Stem Cells Are Functionally Impaired with Reduced Hematopoietic Support

Targeting Autophagy As a Potential Therapeutic Strategy for the Treatment of AML

CITED2 Cooperates with Low PU.1 and DNMT3A to Maintain Self-Renewal in Hematopoietic Stem Cells

Loss of ASXL1 Triggers an Apoptotic Response in Human Hematopoietic Stem and Progenitor Cells

Establishing Human Niche Xenograft Models for Myeloid and Lymphoid Leukemia Driven By MLL-AF9

Loss of ASXL1 Triggers an Apoptotic Response in Human Hematopoetic Stem and Progenitor Cells

ATG5 and ATG7 Fulfill Essential and Non-Redundant Roles in Human Hematopoietic Stem/Progenitor Cells

Mesenchymal Stem Cells from Patients 1 Year Following Autologous Stem Cell Transplantation Have a Pro-Inflammatory and Senescent Phenotype Compromising the Support of Hematopoietic Stem Cells

Differential Localization Of RAC1 and RAC2 Reflects Their Specific Functions In Normal and Leukemic Human Hematopoietic Stem/Progenitor Cells

Decreased PU.1 and Enhanced CITED2 Cooperate To Maintain Self-Renewal In Hematopoietic Stem/Progenitors

Convergence Of Hypoxia and TGFβ Pathways On Cell Cycle Regulation In Human Hematopoietic Stem/Progenitor Cells

Establishing Human Niche Xenograft Models For Myeloid and Lymphoid Leukemia Driven By MLL-AF9

Mouse Versus Human Extrinsic Cues Dictate Transformation Potential In BCR-ABL/BMI1-Induced Leukemia In Humanized Xenograft Models

Autologous Stem Cell Transplantation Induces a Phenotypical Shift From CMP to GMP Progenitors, Reduces Clonogenic Potential and Enhances in Vitro and In Vivo Cycling Activity Defined by 18 f-FLT PET Scan.

The Polycomb Gene BMI1 Collaborates with BCR-ABL in Leukemic Transformation of Human Cord Blood CD34+ Cells.

Transcription Factor Dosage: Maximal STAT5-Induced Proliferation and Stem Cell Self-Renewal at Intermediate STAT5 Activity Levels.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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