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Journal Articles

An Epigenetic Regulator Screen Identifies Novel Targets That Sensitize MLL -Rearranged Leukemia to DOT1L Inhibition

Blood (2016) 128 (22): 571.

https://doi.org/10.1182/blood.V128.22.571.571

Published: 2016

Journal Articles

BET Bromodomain Degradation As a Therapeutic Strategy in Multiple Myeloma

Geoffrey M. Matthews, PhD, Sara Gandolfi, MD, Johanna Bruggentheis, Ricardo De Matos Simoes, PhD, Dennis L Buckley, PhD, Yiguo Hu, MD PhD, Michal Sheffer, PhD, Hayley Poarch, James E. Bradner, MD, Constantine S Mitsiades, MD PhD

Blood (2016) 128 (22): 1062.

https://doi.org/10.1182/blood.V128.22.1062.1062

Published: 2016

Journal Articles

Leukemia-Specific Delivery of Mutant NOTCH1 Targeted Therapy

Giovanni Roti, MD PhD, Jun Qi, PhD, Samuel Kitara, Anthony C. Varca, Marta Sanchez-Martin, PhD, Andrew L. Kung, MD PhD, Adolfo A. Ferrando, MD PhD, James E. Bradner, MD, Kimberly Stegmaier, MD

Blood (2016) 128 (22): 889.

https://doi.org/10.1182/blood.V128.22.889.889

Published: 2016

Journal Articles

High Throughput Screening Identifies Potential Inhibitors of WHSC1/MMSET, a Histone Methyltransferase Oncoprotein in Multiple Myeloma and Acute Lymphocytic Leukemia

Christine M Will, MS, Michael Scholle, MS, Roodolph St. Pierre, BS, Gary Schiltz, PhD, James E. Bradner, MD, Milan Mrksich, PhD, Jonathan D. Licht, MD

Blood (2015) 126 (23): 3251.

https://doi.org/10.1182/blood.V126.23.3251.3251

Published: 2015

Journal Articles

Targeted Treatment of FLT3 -Overexpressing Acute Myeloid Leukemia with MiR-150 Nanoparticles Guided By Conjugated FLT3 Ligand Peptides

Blood (2015) 126 (23): 3784.

https://doi.org/10.1182/blood.V126.23.3784.3784

Published: 2015

Journal Articles

Dose-Dependent Role of the Cohesin Complex in Normal and Malignant Hematopoiesis

Aaron D. Viny, MD MS, Christopher J. Ott, PhD, Barbara Spitzer, MD, Martin A Rivas, PhD, Cem Meydan, Efthymia Papalexi, Dana Yelin, MD, Kaitlyn Shank, BS, Jaime Reyes, April Chiu, MD, Swapna Thota, MD, Jaroslaw P Maciejewski, MD PhD FACP, Ari Melnick, MD, James E. Bradner, MD, Ross L. Levine, MD

Blood (2015) 126 (23): 435.

https://doi.org/10.1182/blood.V126.23.435.435

Published: 2015

Journal Articles

JQ1, a Selective Bromodomain Inhibitor, Augment the Immunogenicity of Mantle Cell Lymphoma By Influencing the Expression of PD-L1

Hongwei Wang, MD, Fengdong Cheng, MD, Jie Cheng, PhD, Alejandro Villagra, PhD, Jianguo Tao, MD PhD, James E. Bradner, MD, Eduardo M. Sotomayor, MD

Blood (2015) 126 (23): 822.

https://doi.org/10.1182/blood.V126.23.822.822

Published: 2015

Journal Articles

Enhancer Landscapes Reveal Transcription Factor Network Dependencies in Chronic Lymphocytic Leukemia

Christopher J. Ott, PhD, Alexander J. Federation, PhD, Siddha Kasar, PhD, Josephine L. Klitgaard, MSc,PhD, Stacey M. Fernandes, Jennifer R. Brown, MD PhD, James E. Bradner, MD

Blood (2015) 126 (23): 436.

https://doi.org/10.1182/blood.V126.23.436.436

Published: 2015

Journal Articles

Discovery and Characterization of Promoter and Super-Enhancer-Associated Dependencies through E2F and BET Bromodomains in Multiple Myeloma

Mariateresa Fulciniti, Charles Y. Lin, Mehmet K Samur, PhD, Matthew Lawlor, Kenneth C Anderson, James E. Bradner, MD, Nikhil C. Munshi, MD

Blood (2015) 126 (23): 838.

https://doi.org/10.1182/blood.V126.23.838.838

Published: 2015

Journal Articles

Genome-Wide Mapping Reveals BRD4 in Regulation of Tumor-Driver Genes in Cutaneous T-Cell Lymphoma

Anjali Mishra, PhD, Alex Hartlage, BS, Laura Sullivan, Leah Grinshpun, Sonya Kwiatkowski, Jun Qi, PhD, James E. Bradner, MD, Pierluigi Porcu, MD, Michael A. Caligiuri, MD

Blood (2015) 126 (23): 589.

https://doi.org/10.1182/blood.V126.23.589.589

Published: 2015

Journal Articles

Functional and Clinical Relevance of Splicing Factor SRSF1 in Multiple Myeloma (MM)

Mariateresa Fulciniti, PhD, Manoj Bhasin, Mehmet Kemal Samur, PhD, Rajya Lakshmi Bandi, BS, Naim Rashid, PhD, Reyes Jaime, Charles Lin, Kenneth C. Anderson, MD, Giovanni Parmigiani, PhD, James E. Bradner, MD, Nikhil C. Munshi, MD

Blood (2014) 124 (21): 3388.

https://doi.org/10.1182/blood.V124.21.3388.3388

Published: 2014

Journal Articles

Targeting BCL6 and Germinal Centers (GCs) in Chronic Graft-Versus-Host Disease (cGVHD) Using Direct and Epigenomic Therapies

Blood (2014) 124 (21): 535.

https://doi.org/10.1182/blood.V124.21.535.535

Published: 2014

Journal Articles

Eradication of Chronic Myelogenous Leukemia By Inactivation of the Polycomb Group Protein EZH2

Huafeng Xie, PhD, Cong Peng, PhD, Jun Qi, PhD, Giullia Cheloni, Partha Das, PhD, Jialiang Huang, PhD, Minh Nguyen, Shaoguang Li, MD PhD, James E. Bradner, MD, Stuart H. Orkin, MD

Blood (2014) 124 (21): 778.

https://doi.org/10.1182/blood.V124.21.778.778

Published: 2014

Journal Articles

Bromodomain-Containing Protein 4 (BRD4): A Novel Marker and Drug Target Expressed In Neoplastic Cells In Advanced Mast Cell Neoplasms

Ghaith Wedeh, Emir Hadzijusufovic, DVM, Sabine Cerny-Reiterer, D.V.M, Harald Herrmann, M.D., Katharina Blatt, MSc, Ph.D., Gregor Eisenwort, M.D., Ph.D, Gregor Hoermann, M.D., Ph.D., Wolfgang R Sperr, M.D., Leonhard Müllauer, M.D., Christopher R. Vakoc, M.D., Ph.D., James E Bradner, MD, Hans-Peter Horny, MD, Michael Willmann, D.V.M., Johannes Zuber, MD, Michel Arock, PharmD, Ph.D, Peter Valent

Blood (2013) 122 (21): 3747.

https://doi.org/10.1182/blood.V122.21.3747.3747

Published: 2013

Journal Articles

Inhibition Of H3K27-Methylome As a Novel Therapeutic Strategy In Multiple Myeloma

Maria Gkotzamanidou, MD, PhD, Masood A Shammas, PhD, Jun Qi, PhD, Mehmet Kemal Samur, PhD, Teru Hideshima, MD, PhD, Meletios A. Dimopoulos, MD, Kenneth C. Anderson, MD, James E Bradner, MD, Nikhil Munshi, MD

Blood (2013) 122 (21): 3162.

https://doi.org/10.1182/blood.V122.21.3162.3162

Published: 2013

Journal Articles

Combined Therapy With BRD4 Antagonist and JAK Inhibitor Is Synergistically Lethal Against Human Myeloproliferative Neoplasm (MPN) Cells

John A Valenta, M.S., Warren Fiskus, Ph.D, Taghi Manshouri, Ph.D., Sunil Sharma, MD, Jun Qi, PhD, Leasha J Schaub, M.S., Bhavin Shah, Melissa Rodriguez, M.D., Ph.D, Santhana Devaraj, Ph.D, Swaminathan Padmanabhan Iyer, MD, Srdan Verstovsek, MD, PhD, James E Bradner, MD, Kapil N. Bhalla, MD

Blood (2013) 122 (21): 2842.

https://doi.org/10.1182/blood.V122.21.2842.2842

Published: 2013

Journal Articles

Increased Expression Of IL-15 Promotes Cutaneous T-Cell Lymphomagenesis Via The Upregulation Of Histone Deacetylases: Evidence For Successful Preclinical Targeting

Anjali Mishra, Ph.D., Krista M.D. La Perle, DVM, PhD, Dipl. ACVP, Laura Sullivan, BS, Gregory H Sams, Douglas P Curphey, Kathleen McConnell, BS, Jun Qi, PhD, Henry K Wong, MD, PhD, Samuel K Kulp, PhD, Soledad Fernandez, PhD, James E Bradner, MD, Guido Marcucci, MD, Ching-Shih Chen, PhD, Pierluigi Porcu, MD, Michael A. Caligiuri, MD

Blood (2013) 122 (21): 1826.

https://doi.org/10.1182/blood.V122.21.1826.1826

Published: 2013

Journal Articles

Spontaneous DNA Damage and Aberrant Epigenome In Multiple Myeloma Constitute The Path To Disease Genomic Instability

Maria Gkotzamanidou, MD, PhD, Masood A. Shammas, Vassilis L. Souliotis, Jagannath Pal, MD, Jun Qi, Ph.D., Andrew Brown, James E Bradner, MD, Kenneth C. Anderson, MD, Nikhil C. Munshi, MD

Blood (2013) 122 (21): 4884.

https://doi.org/10.1182/blood.V122.21.4884.4884

Published: 2013

Journal Articles

Regulation Of Normal and Malignant Hoxa Gene Expression Through Higher H3K79 Methylated States

Aniruddha J Deshpande, Ph.D, Liying Chen, Ph.D., Amit U. Sinha, PhD, Nan Zhu, PhD, David Chen, Ph.D., Jenny Chang, Andrei V. Krivtsov, PhD, Kathrin Bernt, MD, James E Bradner, MD, Scott A. Armstrong, MD, PhD

Blood (2013) 122 (21): 2492.

https://doi.org/10.1182/blood.V122.21.2492.2492

Published: 2013

Journal Articles

Disruption Of Super Enhancer-Driven Cancer Dependencies In Diffuse Large B-Cell Lymphoma

Bjoern Chapuy, MD, PhD, McKeown Michael, Charles Y. Lin, PhD, Stefano Monti, PhD, Margaretha GM Roemer, Jun Qi, Peter B. Rahl, PhD, Heather Sun, Kelly T. Yeda, Andrew L. Kung, MD, PhD, Scott J. Rodig, MD, PhD, Richard A. Young, PhD, Margaret A. Shipp, MD, James E. Bradner, MD

Blood (2013) 122 (21): 3021.

https://doi.org/10.1182/blood.V122.21.3021.3021

Published: 2013

NARROW

An Epigenetic Regulator Screen Identifies Novel Targets That Sensitize MLL -Rearranged Leukemia to DOT1L Inhibition

BET Bromodomain Degradation As a Therapeutic Strategy in Multiple Myeloma

Leukemia-Specific Delivery of Mutant NOTCH1 Targeted Therapy

High Throughput Screening Identifies Potential Inhibitors of WHSC1/MMSET, a Histone Methyltransferase Oncoprotein in Multiple Myeloma and Acute Lymphocytic Leukemia

Targeted Treatment of FLT3 -Overexpressing Acute Myeloid Leukemia with MiR-150 Nanoparticles Guided By Conjugated FLT3 Ligand Peptides

Dose-Dependent Role of the Cohesin Complex in Normal and Malignant Hematopoiesis

JQ1, a Selective Bromodomain Inhibitor, Augment the Immunogenicity of Mantle Cell Lymphoma By Influencing the Expression of PD-L1

Enhancer Landscapes Reveal Transcription Factor Network Dependencies in Chronic Lymphocytic Leukemia

Discovery and Characterization of Promoter and Super-Enhancer-Associated Dependencies through E2F and BET Bromodomains in Multiple Myeloma

Genome-Wide Mapping Reveals BRD4 in Regulation of Tumor-Driver Genes in Cutaneous T-Cell Lymphoma

Functional and Clinical Relevance of Splicing Factor SRSF1 in Multiple Myeloma (MM)

Targeting BCL6 and Germinal Centers (GCs) in Chronic Graft-Versus-Host Disease (cGVHD) Using Direct and Epigenomic Therapies

Eradication of Chronic Myelogenous Leukemia By Inactivation of the Polycomb Group Protein EZH2

Bromodomain-Containing Protein 4 (BRD4): A Novel Marker and Drug Target Expressed In Neoplastic Cells In Advanced Mast Cell Neoplasms

Inhibition Of H3K27-Methylome As a Novel Therapeutic Strategy In Multiple Myeloma

Combined Therapy With BRD4 Antagonist and JAK Inhibitor Is Synergistically Lethal Against Human Myeloproliferative Neoplasm (MPN) Cells

Increased Expression Of IL-15 Promotes Cutaneous T-Cell Lymphomagenesis Via The Upregulation Of Histone Deacetylases: Evidence For Successful Preclinical Targeting

Spontaneous DNA Damage and Aberrant Epigenome In Multiple Myeloma Constitute The Path To Disease Genomic Instability

Regulation Of Normal and Malignant Hoxa Gene Expression Through Higher H3K79 Methylated States

Disruption Of Super Enhancer-Driven Cancer Dependencies In Diffuse Large B-Cell Lymphoma

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American Society of Hematology

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American Society of Hematology

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