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Journal Articles

Targeted Inhibition of mTORC1 and mTORC2 by the Active-Site mTOR Inhibitors, PP-242 and OSI-027, Has Cytotoxic Effects In T-Cell Acute Lymphoblastic Leukemia

Camilla Evangelisti, PhD, Francesca Chiarini, PhD, Francesca Ricci, BS, Pierluigi Tazzari, MD, Andrea Pession, MD, PhD, James A McCubrey, PhD, Alberto M. Martelli, MD

Blood (2010) 116 (21): 3242.

https://doi.org/10.1182/blood.V116.21.3242.3242

Published: 2010

Journal Articles

Roles of Raf/MEK/ERK and PI3K/Akt/mTOR Signaling and p53 Pathways on Apoptosis, Drug Resistance and Therapeutic Sensitivity of Early Hematopoietic Precursor Cells

Stephen Lee Abrams, Linda S Steelman, BS., MS, Melissa L Skolosky, BS, Giovanni Ligresti, PhD, Massimo Libra, MD., James A McCubrey, PhD

Blood (2008) 112 (11): 503.

https://doi.org/10.1182/blood.V112.11.503.503

Published: 2008

Journal Articles

Roles of Raf/MEK/ERK and PI3K/Akt/mTOR Pathways in Prevention of Apoptosis and Induction of Drug Resistance in Myeloid Hematopoietic Cells.

Steve L. Abrams, BS, Camilla Evangelisti, PhD, Francesca Chiarini, BS, Negin Misaghian, BS, Jorg Basecke, MD, Michele Millela, MD, Agostino Tafuri, MD, Massimo Libra, MD, Franca Stivala, MD, Marina Konopleva, MD, Michael Andreeff, MD, Linda S. Steelman, MS, Jacob Troppmair, PhD, Alberto M. Martelli, MD, James A. McCubrey, PhD

Blood (2007) 110 (11): 641.

https://doi.org/10.1182/blood.V110.11.641.641

Published: 2007

Journal Articles

Comparative Gene Profiling of Acute Myeloid Leukemia (AML) and Malignant Melanoma (MEL) Cell Lines Exposed to the MEK Inhibitor PD0325901 Reveals Common Effectors of the MEK/ERK Kinase Module.

Michele Milella, MD, Sabina Chiaretti, MD, PhD, Maria R. Ricciardi, PhD, Simona Tavolaro, BSc, Ludovica Ciuffreda, PhD, Barbara Benassi, PhD, Alfonso Bellacosa, MD, PhD, Gianfranco Peluso, PhD, Paola Bergamo, MS, James A. McCubrey, PhD, Francesco Cognetti, MD, Gabriella Zupi, PhD, Robert Foà, MD, Agostino Tafuri, MD

Blood (2007) 110 (11): 3470.

https://doi.org/10.1182/blood.V110.11.3470.3470

Published: 2007

Journal Articles

The AKT Inhibitor, A443654, Induces Cell Cycle Arrest, Apoptosis and Synergizes with Chemotherapeutic Drugs in Multi-Drug Resistant T-Cell Acute Lymphoblastic Leukemia - A Novel Agent for Therapy of Drug Resistant ALL.

James A. McCubrey, PhD, William L. Blalock, PhD, Pier Luigi Tazzari, MD, Alessandra Cappellini, PhD, Ilaria Iacobucci, PhD, Francesca Chiarini, BS, Steve L. Abrams, BS, Emanuela Ottaviani, PhD, Giovanni Martinelli, MD, Agostino Tafuri, MD, Lucio Cocco, MD PhD, Alberto M. Martelli, MD PhD, Federica Fala, MD

Blood (2007) 110 (11): 3344.

https://doi.org/10.1182/blood.V110.11.3344.3344

Published: 2007

Journal Articles

The Novel Akt Inhibitor Perifosine Induces Apoptosis, Cell Cycle Arrest and Synergizes with Chemotherapeutic Drugs in Acute Myelogenous Leukemia Cells by a JNK Dependent Mechanism - A Novel Therapeutic Approach for Leukemia Displaying Elevated Akt Signaling.

Alberto M. Martelli, MD, PhD, Veronica Papa, BS, Pier Luigi Tazzari, MD, Francesca Chiarini, BS, Alessandra Cappellini, PhD, Francesca Ricci, BS, Anna Maria Billi, PhD, Camilla Evangelisti, PhD, Steve L. Abrams, BS, Emanuela Ottaviani, PhD, Giovanni Martinelli, MD, James A. McCubrey, PhD

Blood (2007) 110 (11): 3355.

https://doi.org/10.1182/blood.V110.11.3355.3355

Published: 2007

Journal Articles

Mutations in the Catalytic Subunit of Class IA PI3K Are Leukemogenic In Vivo.

Stefan Horn, James A. McCubrey, Carol Stocking, Lorenz Trumper, Jorg Basecke

Blood (2007) 110 (11): 875.

https://doi.org/10.1182/blood.V110.11.875.875

Published: 2007

Journal Articles

Dominant Role of Raf/MEK/ERK Signaling in Hematopoietic Cell Cycle Progression, Prevention of Apoptosis and Drug Resistance.

James A. McCubrey, PhD, Steven L. Abrams, BS, Linda S. Steelman, MS, Ellis W.T. Wong, BS, William H. Chappell, MS, Jorg Basecke, MD, Franca Stivala, MD, Massimo Libra, MD, PhD, Michele Milella, MD, Agostino Tafuri, MD, Jacob Troppmair, PhD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD, Camilla Evangelisti, BS, Alberto M. Martelli, MD, PhD

Blood (2006) 108 (11): 1116.

https://doi.org/10.1182/blood.V108.11.1116.1116

Published: 2006

Journal Articles

Role of BRAF Mutations in Hematopoietic Malignancies and the Induction of Cytokine-Independence-Synergy with PI3K/Akt Pathway.

Massimo Libra, MD, Maria C. Mazzarino, MD, Valli De Re, PhD, Linda S. Steelman, MS, Steven L. Abrams, BS, Fred E. Bertrand, PhD, John G. Shelton, PhD, Sarah Molton, PhD, Martin McMahon, PhD, James A. McCubrey, PhD

Blood (2005) 106 (11): 4291.

https://doi.org/10.1182/blood.V106.11.4291.4291

Published: 2005

Journal Articles

Key Roles of the Raf-1 and Akt in Drug Resistance, Cell Cycle Progression and the Prevention of Apoptosis in Hematopoietic Cells.

Steven L. Abrams, BS, Linda S. Steelman, MS, John G. Shelton, PhD, William H. Chappell, MS, Ellis W.T. Wong, BS, Fred E. Bertrand, PhD, James A. McCubrey, PhD

Blood (2005) 106 (11): 1356.

https://doi.org/10.1182/blood.V106.11.1356.1356

Published: 2005

Journal Articles

B-Raf–dependent expression of vascular endothelial growth factor–A in Kaposi sarcoma–associated herpesvirus-infected human B cells

Shaw M. Akula, Patrick W. Ford, Audy G. Whitman, Khalief E. Hamden, Benjaman A. Bryan, Paul P. Cook, James A. McCubrey

Blood (2005) 105 (11): 4516–4522.

https://doi.org/10.1182/blood-2004-09-3683

Published: 2005

Journal Articles

Effects of EGF-R on Signal Transduction and Anti-Apoptotic Cascades in Hematopoietic Cells: EGF-R Activates Multiple Signal Transduction Cascades Which Result in the Prevention of Apoptosis in the Absence of Autocrine Cytokines.

John G. Shelton, B.S., Linda S. Steelman, M.S., Martin McMahon, Ph.D., James A. McCubrey, Ph.D.

Blood (2004) 104 (11): 1264.

https://doi.org/10.1182/blood.V104.11.1264.1264

Published: 2004

Journal Articles

Effects of EGF-R on Transcription Factor Activation in Hematopoietic Cells: EGF-R Activates Multiple Transcription Factors Which Induce Proliferation in the Absence of Autocrine Cytokines.

John G. Shelton, B.S., Linda S. Steelman, M.S., Martin McMahon, Ph.D., James A. McCubrey, Ph.D.

Blood (2004) 104 (11): 4185.

https://doi.org/10.1182/blood.V104.11.4185.4185

Published: 2004

Journal Articles

A Novel Ring-Substituted Diindolylmethane 1,1-bis [3′-(5-methoxyindolyl)]-1-(p-t-butylphenyl) Methane Abrogates ERK Activation and Induces Apoptosis in Acute Myeloid Leukemia (AML).

Rooha Contractor, Ismael J. Samudio, Ph.D., Zeev Estrov, M.D., David Harris, James A. McCubrey, Ph.D., Stephen H. Safe, Ph.D., Michael Andreeff, M.D., Ph.D., Marina Konopleva, M.D., Ph.D.

Blood (2004) 104 (11): 3399.

https://doi.org/10.1182/blood.V104.11.3399.3399

Published: 2004

NARROW

Targeted Inhibition of mTORC1 and mTORC2 by the Active-Site mTOR Inhibitors, PP-242 and OSI-027, Has Cytotoxic Effects In T-Cell Acute Lymphoblastic Leukemia

Roles of Raf/MEK/ERK and PI3K/Akt/mTOR Signaling and p53 Pathways on Apoptosis, Drug Resistance and Therapeutic Sensitivity of Early Hematopoietic Precursor Cells

Roles of Raf/MEK/ERK and PI3K/Akt/mTOR Pathways in Prevention of Apoptosis and Induction of Drug Resistance in Myeloid Hematopoietic Cells.

Comparative Gene Profiling of Acute Myeloid Leukemia (AML) and Malignant Melanoma (MEL) Cell Lines Exposed to the MEK Inhibitor PD0325901 Reveals Common Effectors of the MEK/ERK Kinase Module.

The AKT Inhibitor, A443654, Induces Cell Cycle Arrest, Apoptosis and Synergizes with Chemotherapeutic Drugs in Multi-Drug Resistant T-Cell Acute Lymphoblastic Leukemia - A Novel Agent for Therapy of Drug Resistant ALL.

The Novel Akt Inhibitor Perifosine Induces Apoptosis, Cell Cycle Arrest and Synergizes with Chemotherapeutic Drugs in Acute Myelogenous Leukemia Cells by a JNK Dependent Mechanism - A Novel Therapeutic Approach for Leukemia Displaying Elevated Akt Signaling.

Mutations in the Catalytic Subunit of Class IA PI3K Are Leukemogenic In Vivo.

Dominant Role of Raf/MEK/ERK Signaling in Hematopoietic Cell Cycle Progression, Prevention of Apoptosis and Drug Resistance.

Role of BRAF Mutations in Hematopoietic Malignancies and the Induction of Cytokine-Independence-Synergy with PI3K/Akt Pathway.

Key Roles of the Raf-1 and Akt in Drug Resistance, Cell Cycle Progression and the Prevention of Apoptosis in Hematopoietic Cells.

B-Raf–dependent expression of vascular endothelial growth factor–A in Kaposi sarcoma–associated herpesvirus-infected human B cells

Effects of EGF-R on Signal Transduction and Anti-Apoptotic Cascades in Hematopoietic Cells: EGF-R Activates Multiple Signal Transduction Cascades Which Result in the Prevention of Apoptosis in the Absence of Autocrine Cytokines.

Effects of EGF-R on Transcription Factor Activation in Hematopoietic Cells: EGF-R Activates Multiple Transcription Factors Which Induce Proliferation in the Absence of Autocrine Cytokines.

A Novel Ring-Substituted Diindolylmethane 1,1-bis [3′-(5-methoxyindolyl)]-1-(p-t-butylphenyl) Methane Abrogates ERK Activation and Induces Apoptosis in Acute Myeloid Leukemia (AML).

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American Society of Hematology

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American Society of Hematology

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