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Journal Articles

Marrow Stromal Cells Secrete FGF2 in Exosomes, Providing Paracrine Protection for Leukemia Cells from Kinase Inhibitors

Elie Traer, MD PhD, Brian J. Druker, MD, Jakki Martinez, Nathalie Javidi-Sharifi, Isabel English, BA, Anupriya Agarwal, PhD, Jennifer Dunlap, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 306.
https://doi.org/10.1182/blood.V130.Suppl_1.306.306
Published: 2017
Journal Articles

FGF2 from Bone Marrow Stroma Protects Acute Myeloid Leukemia Cells from the FLT3 Inhibitor Quizartinib and Facilitates Acquisition of Resistance Mutations

Elie Traer, MD, Nathalie Javidi-Sharifi, Jacqueline Martinez, MS, Isabel English, Jennifer Dunlap, MD, Anupriya Agarwal, Tibor J. Kovacsovics, MD, Jeffrey W. Tyner, Melissa Wong, PhD, Brian J. Druker, MD
Journal: Blood
Blood (2016) 128 (22): 1080.
https://doi.org/10.1182/blood.V128.22.1080.1080
Published: 2016
Journal Articles

Identification of Effective Combinations of Targeted Drugs for Hematologic Malignancies

Stephen E Kurtz, PhD, Christopher A. Eide, Andy Kaempf, Vishesh Khanna, BS, Samantha L. Savage, Angela Rofelty, Isabel English, Hibery Ho, Motomi Mori, PhD, Elie Traer, MD, Brian J. Druker, MD, Jeffrey W. Tyner, PhD
Journal: Blood
Blood (2016) 128 (22): 836.
https://doi.org/10.1182/blood.V128.22.836.836
Published: 2016
Journal Articles

FGF2-Containing Exosomes Secreted from Bone Marrow Stromal Cells Protect Leukemia Cells from Tyrosine Kinase Inhibitors

Jacqueline Martinez, MS, Nathalie Javidi-Sharifi, Isabel English, Shelton A. Viola, MD, Danielle Jorgens, PhD, Brian J. Druker, MD, Elie Traer, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2465.
https://doi.org/10.1182/blood.V126.23.2465.2465
Published: 2015
Journal Articles

Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations

Elie Traer, Nathalie Javidi-Sharifi, Anupriya Agarwal, Jennifer Dunlap, Isabel English, Jacqueline Martinez, Jeffrey W. Tyner, Melissa Wong, Brian J. Druker
Journal: Blood
Blood (2014) 123 (10): 1516–1524.
https://doi.org/10.1182/blood-2013-07-518381
Published: 2014
Includes: Supplemental data
Journal Articles

FGF2 Promotes Resistance To Quizartinib In Vitro, and FGF2 Increases In The Marrow Of Patients Prior To Resistance

Elie Traer, MD, PhD, Nathalie Javidi-Sharifi, Anupriya Agarwal, Jennifer B Dunlap, MD, Isabel English, Jacqueline Martinez, Tibor J. Kovacsovics, MD, Jeffrey W. Tyner, Melissa Wong, PhD, Brian J. Druker
Journal: Blood
Blood (2013) 122 (21): 2541.
https://doi.org/10.1182/blood.V122.21.2541.2541
Published: 2013
Journal Articles

FGF2 Mediates Resistance In CML Patients In The Absence Of Kinase Domain Mutations, and Resistance Is Overcome By Ponatinib

Elie Traer, MD, PhD, Nathalie Javidi-Sharifi, Anupriya Agarwal, Jennifer B Dunlap, MD, Isabel English, Jacqueline Martinez, Jeffrey W. Tyner, Melissa Wong, PhD, Brian J. Druker
Journal: Blood
Blood (2013) 122 (21): 3983.
https://doi.org/10.1182/blood.V122.21.3983.3983
Published: 2013