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Journal Articles

Increased Levels of Histone in Human Plasma in Septic Patients with DIC

Kazuo Kawasugi, MD PhD, Tadashi Yamamoto, MD, Naoki Shirafuji, MD PhD, Shingo Yamada, PhD, Ito Takashi, MD PhD, Ikuro Maruyama, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1104.
https://doi.org/10.1182/blood.V126.23.1104.1104
Published: 2015
Journal Articles

Combined Dabigatran and Antiplatelet Agents Assessed by the Novel Microchip-Based Flow Chamber System

Kenichi Tanaka, MD, MSc, Kazuya Hosokawa, PhD, Tomoko Ohnishi, Hisayo Sameshima, Takehiko Koide, DSc, Ikuro Maruyama, PhD, MD
Journal: Blood
Blood (2012) 120 (21): 1167.
https://doi.org/10.1182/blood.V120.21.1167.1167
Published: 2012
Journal Articles

Activated Protein C Inhibits Lipopolysaccharide-Induced Anandamide and 2-Arachidonoylglycerol Generation In Vitro and In Vivo .

Ikuro Maruyama, Yin Wang, Yan Liu, Koichi Kawahara, Munekazu Yamakuchi, Teruto Hashiguchi, Toru Obata
Journal: Blood
Blood (2007) 110 (11): 1754.
https://doi.org/10.1182/blood.V110.11.1754.1754
Published: 2007
Journal Articles

Efficacy and Safety of Recombinant Human Soluble Thrombomodulin (ART-123) in Disseminated Intravascular Coagulation (DIC): Results of Phase III Randomized, Double-Blind, Clinical Trial.

Hidehiko Saito, MD, Ikuro Maruyama, MD, Shuji Shimazaki, MD, Yasuhiro Yamamoto, MD, Naoki Aikawa, MD, FACS, Ryuzo Ohno, MD, Akio Hirayama, MD, Tamotsu Matsuda, MD, Hidesaku Asakura, MD, Mitsuyoshi Nakashima, MD, Nobuo Aoki, MD
Journal: Blood
Blood (2006) 108 (11): 576.
https://doi.org/10.1182/blood.V108.11.576.576
Published: 2006
Journal Articles

HMGB1 Derived from Macrophages Acts as an Angiogenic Factor.

Ikuro Maruyama, MD, PhD, Ko-ichi Kawahara, PHD, Takashi Ito, MD, Yoko Oyama, MD, Kazunori Takenouchi, MD, Toshiaki Shimizu, MD, Kiyoshi Kikuchi, MD, Teruto Hashiguchi, MD, PHD
Journal: Blood
Blood (2006) 108 (11): 3852.
https://doi.org/10.1182/blood.V108.11.3852.3852
Published: 2006
Journal Articles

Plasma Levels of High Mobility Group Box Protein in Patients with Organ Failure, Disseminated Intravascular Coagulation or Poor Outcome.

Hideo Wada, MD, PhD, Tsutomu Nobori, MDPhD, Shingo Yamada, PhD, Ikuro Maruyama, MDPhD
Journal: Blood
Blood (2005) 106 (11): 2142.
https://doi.org/10.1182/blood.V106.11.2142.2142
Published: 2005
Journal Articles

Dynamic Defense System Against HMGB1, a Proinflammatory and Lethal Mediator in Severe Infections and Malignancies.

Takashi Ito, MD, Kazuhiro Abeyama, MD PhD, Ko-ichi Kawahara, PhD, Kamal K. Biswas, Tomonori Uchimura, MD PhD, Shingo Yamada, PhD, Teruto Hashiguchi, MD PhD, Ikuro Maruyama, MD PhD
Journal: Blood
Blood (2004) 104 (11): 3827.
https://doi.org/10.1182/blood.V104.11.3827.3827
Published: 2004
Journal Articles

The N-Terminal Domain of Thrombomodulin Sequesters HMGB1: A Novel Anti-Inflammatory Mechanism.

Kazuhiro Abeyama, MD. PhD., Yasushi Yoshimoto, PhD, Ikuro Maruyama, MD. PhD.
Journal: Blood
Blood (2004) 104 (11): 3435.
https://doi.org/10.1182/blood.V104.11.3435.3435
Published: 2004
Journal Articles

Functional Vanilloid Receptor VR1 Is Expressed on Megakaryocytes and Platelets, and Acts as a Sensor for Hypertheimia Generating Endocannabinoids.

Ikuro Maruyama, MD.PhD., Kentaro Soejima, DDS., Toshiaki Shimi, MD., Kazuhiro Abeyama, MD.PhD., Teruto Hashiguchi, MD.PhD.
Journal: Blood
Blood (2004) 104 (11): 4001.
https://doi.org/10.1182/blood.V104.11.4001.4001
Published: 2004
Journal Articles

Uric Acid Induces High Mobility Group Box1 Protein Release in Monocytes/Macrophages through P38 MAPK, ERK1/2, JNK and AP-1 Activation.

Kamal K. Biswas, PhD, Yoko Oyama, MD, Kazuhiro Abeyama, MD, PhD, Teruto Hashiguchi, MD, PhD, Ikuro Maruyama, MD, PhD
Journal: Blood
Blood (2004) 104 (11): 1464.
https://doi.org/10.1182/blood.V104.11.1464.1464
Published: 2004