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Journal Articles

Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease

Kaiqi Sun, BS, Yang Xia, MD PhD, Angelo D'Alessandro, PhD, Mostafa H Ahmed, PhD, Yujin Zhang, MD, Anren Song, PhD, Tzu-Ping KO, Travis Nemkov, Julie Haines, Hongyu Wu, PhD, Morayo G. Adebiyi, BS, Hong Liu, MD, Aji Huang, BS, MS, Zhangzhe Peng, MD, Yuan Edward Wen, Alexander Wen, Vladimir Berka, PhD, Mikhail Bogdanov, PhD, Osheiza Abdulmalik, DVM, MS, Gregory J Kato, MD, Ah-lim Tsai, Modupe Idowu, MD, Harinder S. Juneja, MD, Rodney E. Kellems, PhD, Kirk C Hansen, PhD, Martin K. Safo, PhD
Journal: Blood
Blood (2016) 128 (22): 2474.
https://doi.org/10.1182/blood.V128.22.2474.2474
Published: 2016
Journal Articles

Sphingosine-1-Phosphate (S1P) Signaling through S1P Receptor 1 (S1PR1) in Macrophage Contributes to Pain in Sickle Cell Disease

Morayo G. Adebiyi, BS, Yujin Zhang, MD, Kaiqi Sun, BS, Xia Hu, MD, Shusuan Zhao, MD, Hongyu Wu, PhD, Jacob Couturier, PhD, Dorothy L. Lewis, PhD, Edgar T. Walters, PhD, Yang Xia, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2476.
https://doi.org/10.1182/blood.V128.22.2476.2476
Published: 2016
Journal Articles

Erythrocytes Retain "Hypoxic Purinergic Memory" for Faster Acclimatization upon Re-Ascent

Anren Song, PhD, Yujin Zhang, PhD, Hong Liu, MD, Kaiqi Sun, BS, Zhangzhe Peng, MD, Hongyu Wu, PhD, Rodney E. Kellems, PhD, Robert Roach, PhD, Yang Xia, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4854.
https://doi.org/10.1182/blood.V128.22.4854.4854
Published: 2016
Journal Articles

Metabolomic Profiling Identifies Hypoxia-Induced Imbalanced Lands' Cycle Promotes Sickling and Disease Progression

Hongyu Wu, PhD, Mikhail Bogdanov, PhD, Yujin Zhang, MD, Kaiqi Sun, BS, Anren Song, PhD, Hong Liu, MD, Morayo G, Adebiyi, Danny C. Alexander, Michael V. Milburn, Modupe Idowu, MD, Harinder S. Juneja, MD, Yang Xia, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2134.
https://doi.org/10.1182/blood.V126.23.2134.2134
Published: 2015
Journal Articles

Sustained Elevation of Adenosine-ADORA2B Signaling Promotes Chronic Pain through Neuro-Immune Interaction in Sickle Cell Disease

Morayo G. Adebiyi, BS, Xia Hu, MD, Jialie Luo, PhD, Kaiqi Sun, BS, Thanh-Thuy T. Le, MD PhD, Yujin Zhang, MD, Hongyu Wu, PhD, Hong Liu, MD, Aji Huang, BS, MS, Rodney E. Kellems, PhD, Michael R. Blackburn, PhD, Edgar T. Walters, PhD, Hongzhen Hu, PhD, Yang Xia, MD PhD
Journal: Blood
Blood (2015) 126 (23): 974.
https://doi.org/10.1182/blood.V126.23.974.974
Published: 2015
Journal Articles

Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity

Kaiqi Sun, Yujin Zhang, Mikhail V. Bogdanov, Hongyu Wu, Anren Song, Jessica Li, William Dowhan, Modupe Idowu, Harinder S. Juneja, Jose G. Molina, Michael R. Blackburn, Rodney E. Kellems, Yang Xia
Journal: Blood
Blood (2015) 125 (10): 1643–1652.
https://doi.org/10.1182/blood-2014-08-595751
Published: 2015
Journal Articles

Sphingosine 1-Phosphate (S1P)/S1P Receptor 1 Pathway Has an Essential Role for Sickle Cell Disease

Yujin Zhang, PhD, Shushan Zhao, MD, Hongyu Wu, MD, Xia Hu, MD, Renna Luo, MD, Nicholas Parchim, PhD, Rodney E Kellems, PhD, Yang Xia, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4063.
https://doi.org/10.1182/blood.V124.21.4063.4063
Published: 2014