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Journal Articles

Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen

HR Lijnen, P Carmeliet, A Bouche, L Moons, VA Ploplis, EF Plow, D Collen
Journal: Blood
Blood (1996) 88 (3): 870–876.
https://doi.org/10.1182/blood.V88.3.870.870
Published: 1996
Journal Articles

Staphylokinase, a fibrin-specific plasminogen activator with therapeutic potential?

D Collen, HR Lijnen
Journal: Blood
Blood (1994) 84 (3): 680–686.
https://doi.org/10.1182/blood.V84.3.680.680
Published: 1994
Journal Articles

Regulation by alpha 2-antiplasmin and fibrin of the activation of plasminogen with recombinant staphylokinase in plasma

K Silence, D Collen, HR Lijnen
Journal: Blood
Blood (1993) 82 (4): 1175–1183.
https://doi.org/10.1182/blood.V82.4.1175.1175
Published: 1993
Journal Articles

Pharmacokinetic and thrombolytic properties of chimeric plasminogen activators consisting of a single-chain Fv fragment of a fibrin- specific antibody fused to single-chain urokinase

P Holvoet, Y Laroche, JM Stassen, HR Lijnen, B Van Hoef, F De Cock, A Van Houtven, Y Gansemans, G Matthyssens, D Collen
Journal: Blood
Blood (1993) 81 (3): 696–703.
https://doi.org/10.1182/blood.V81.3.696.696
Published: 1993
Journal Articles

Thrombolytic and pharmacokinetic properties of an immunoconjugate of single-chain urokinase-type plasminogen activator (u-PA) and a bispecific monoclonal antibody against fibrin and against u-PA in baboons

Y Imura, JM Stassen, T Kurokawa, S Iwasa, HR Lijnen, D Collen
Journal: Blood
Blood (1992) 79 (9): 2322–2329.
https://doi.org/10.1182/blood.V79.9.2322.2322
Published: 1992
Journal Articles

Biochemical and biologic properties of rt-PA del (K296-G302), a recombinant human tissue-type plasminogen activator deletion mutant resistant to plasminogen activator inhibitor-1

XK Li, HR Lijnen, L Nelles, B Van Hoef, JM Stassen, D Collen
Journal: Blood
Blood (1992) 79 (2): 417–429.
https://doi.org/10.1182/blood.V79.2.417.417
Published: 1992
Journal Articles

Basic and clinical aspects of fibrinolysis and thrombolysis

D Collen, HR Lijnen
Journal: Blood
Blood (1991) 78 (12): 3114–3124.
https://doi.org/10.1182/blood.V78.12.3114.3114
Published: 1991
Journal Articles

Effect of chemical conjugation of recombinant single-chain urokinase- type plasminogen activator with monoclonal antiplatelet antibodies on platelet aggregation and on plasma clot lysis in vitro and in vivo

M Dewerchin, HR Lijnen, JM Stassen, F De Cock, T Quertermous, MH Ginsberg, EF Plow, D Collen
Journal: Blood
Blood (1991) 78 (4): 1005–1018.
https://doi.org/10.1182/blood.V78.4.1005.1005
Published: 1991
Journal Articles

Comparative thrombolytic properties of bolus injections and continuous infusions of a chimeric (t-PA/u-PA) plasminogen activator in a hamster pulmonary embolism model

HR Lu, HR Lijnen, JM Stassen, D Collen
Journal: Blood
Blood (1991) 78 (1): 125–131.
https://doi.org/10.1182/blood.V78.1.125.125
Published: 1991
Journal Articles

A monoclonal antibody specific for two-chain urokinase-type plasminogen activator. Application to the study of the mechanism of clot lysis with single-chain urokinase-type plasminogen activator in plasma

PJ Declerck, HR Lijnen, M Verstreken, H Moreau, D Collen
Journal: Blood
Blood (1990) 75 (9): 1794–1800.
https://doi.org/10.1182/blood.V75.9.1794.1794
Published: 1990
Journal Articles

The mechanism of plasminogen activation and fibrin dissolution by single chain urokinase-type plasminogen activator in a plasma milieu in vitro

HR Lijnen, B Van Hoef, F De Cock, D Collen
Journal: Blood
Blood (1989) 73 (7): 1864–1872.
https://doi.org/10.1182/blood.V73.7.1864.1864
Published: 1989
Journal Articles

A monoclonal antibody preventing binding of tissue-type plasminogen activator to fibrin: useful to monitor fibrinogen breakdown during t-PA infusion

P Holvoet, HR Lijnen, D Collen
Journal: Blood
Blood (1986) 67 (5): 1482–1487.
https://doi.org/10.1182/blood.V67.5.1482.1482
Published: 1986