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Guo-Cheng Yuan, PhD
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Journal Articles

Fetal Hemoglobin (HbF) Silencer BCL11A Acts through a Novel DNA-Motif in the Gamma-Globin Promoters, Simplifying the Model for Hemoglobin Switching

Nan Liu, PhD, Victoria V Hargreaves, PhD, Jiyoung Hong, PhD, Woojin Kim, PhD, Jesse Kurland, PhD, Qian Zhu, PhD, Falak Sher, PhD, Claudio Macias-Trevino, BS, Jill Rogers, PhD, Guo-Cheng Yuan, PhD, Daniel E. Bauer, MD PhD, Jian Xu, PhD, Martha L Bulyk, PhD, Stuart Orkin
Journal: Blood
Blood (2017) 130 (Supplement 1): 283.
https://doi.org/10.1182/blood.V130.Suppl_1.283.283
Published: 2017
Journal Articles

Single Cell Transcriptional Profiling Reveals Activation of TNF-Alpha Signaling in Hematopoietic Stem and Progenitor Cells from Shwachman-Diamond Syndrome Patients

Cailin Joyce, PhD, Assieh Saadatpour, PhD, Lan Jiang, PhD, Melisa Ruiz-Gutierrez, MDPhD, Ozge Vargel Bolukbasi, PhD, Inga Hofmann, MD, Colin A. Sieff, MB.BCh, Chad Nusbaum, PhD, Akiko Shimamura, MD PhD, Guo-Cheng Yuan, PhD, Carl D. Novina, MDPhD
Journal: Blood
Blood (2016) 128 (22): 335.
https://doi.org/10.1182/blood.V128.22.335.335
Published: 2016
Journal Articles

Crispr-Cas9 Saturating Mutagenesis Reveals an Achilles Heel in the BCL11A Erythroid Enhancer for Fetal Hemoglobin Induction (by Genome Editing)

Daniel E. Bauer, MD, PhD, Matthew C. Canver, B.S., Elenoe C. Smith, PhD, Falak Sher, PhD, Luca Pinello, PhD, Neville E. Sanjana, PhD, Ophir Shalem, PhD, Diane D. Chen, B.S., Patrick G. Schupp, B.S., Divya S. Vinjamur, PhD, Sara P. Garcia, PhD, Sidinh Luc, PhD, Ryo Kurita, PhD, Yukio Nakamura, MD, PhD, Yuko Fujiwara, PhD, Takahiro Maeda, MD, PhD, Guo-Cheng Yuan, PhD, Guillaume Lettre, PhD, Feng Zhang, PhD, Stuart H. Orkin, MD
Journal: Blood
Blood (2015) 126 (23): 638.
https://doi.org/10.1182/blood.V126.23.638.638
Published: 2015
Journal Articles

Developmental Control of Polycomb Subunit Composition Mediates a Switch to Non-Canonical Functions during Hematopoiesis

Jian Xu, PhD, Zhen Shao, PhD, Dan Li, Huafeng Xie, PhD, Woojin Kim, PhD, Jialiang Huang, PhD, Luca Pinello, PhD, Kimberly Glass, PhD, Guo-Cheng Yuan, PhD, Stuart H. Orkin, MD
Journal: Blood
Blood (2014) 124 (21): 241.
https://doi.org/10.1182/blood.V124.21.241.241
Published: 2014
Journal Articles

Fine-Mapping and Genome Editing Reveal An Essential Erythroid Enhancer At The HbF-Associated BCL11A Locus

Daniel E. Bauer, MD, PHD, Sophia C. Kamran, MD, Samuel Lessard, BS, Jian Xu, PhD, Yuko Fujiwara, PhD, Carrie Lin, BS, Zhen Shao, PhD, Matthew C. Canver, BS, Elenoe C. Smith, PhD, Luca Pinello, PhD, Peter J. Sabo, PhD, Jeff Vierstra, BS, Richard A. Voit, BS, Guo-Cheng Yuan, PhD, Matthew H. Porteus, MD, PhD, John Stamatoyannopoulos, MD, Guillaume Lettre, PhD, Stuart H. Orkin, MD
Journal: Blood
Blood (2013) 122 (21): 437.
https://doi.org/10.1182/blood.V122.21.437.437
Published: 2013
Journal Articles

Genomic Determinants of Human Fetal and Adult Erythroid Gene Expression

Jian Xu, PhD, Zhen Shao, PhD, Kimberly Glass, PhD, Daniel E. Bauer, MD, PhD, Luca Pinello, PhD, Ben Van Handel, PhD, Serena Hou, John A. Stamatoyannopoulos, MD, Hanna K. A. Mikkola, MD, PhD, Guo-Cheng Yuan, PhD, Stuart H. Orkin, MD
Journal: Blood
Blood (2012) 120 (21): 1227.
https://doi.org/10.1182/blood.V120.21.1227.1227
Published: 2012