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Journal Articles

Targeting β3 Integrin Psi Domain Inhibits Both Platelet Aggregation and Blood Coagulation: Two Birds with One Stone

Tyler W. Stratton, MSc, Guangheng Zhu, MD, Yiming Wang, MD PhD, Pingguo Chen, PhD, Miguel A. D. Neves, PhD MSc, Reid C. Gallant, MSc, Peter A. A. Norris, BSc, John J. Freedman, MD, Heyu Ni, MD MSc, PhD

Blood (2018) 132 (Supplement 1): 1246.

https://doi.org/10.1182/blood-2018-99-119964

Published: 2018

Journal Articles

Antibodies Against Macrophage CD44 Protect Platelets from FcγR-Mediated Phagocytosis: A Potential Mechanism for CD44 Antibody Amelioration of Murine Immune Thrombocytopenia

Peter A A Norris, BSc, Yawen Wang, MD, Guangheng Zhu, MD, Lin Wang, MD, Ming Huo, MD, Gregory D Fairn, PhD, Heyu Ni, MD MSc, PhD, Alan H Lazarus, PhD

Blood (2017) 130 (Supplement 1): 3639.

https://doi.org/10.1182/blood.V130.Suppl_1.3639.3639

Published: 2017

Journal Articles

Platelet GPIba Is Important for Thrombopoietin Production and Thrombopoietin-Induced Platelet Generation

Miao Xu, MSc, MD, Li Ma, PhD, Naadiya Carrim, PhD, Issaka Yougbare, PhD, June Li, MSc, Pingguo Chen, MD PhD, Guangheng Zhu, MD, Heyu Ni, MD PhD

Blood (2015) 126 (23): 12.

https://doi.org/10.1182/blood.V126.23.12.12

Published: 2015

Journal Articles

Natural Killer Cells Contribute to Pathophysiology of Placenta Leading to Miscarriage in Fetal and Neonatal Alloimmune Thrombocytopenia

Issaka Yougbare, PhD, Tai Wei-she, Bsc, Darko Zdravic, MSc, Pingguo Chen, MD PhD, Guangheng Zhu, MD, Howard Leong-Poi, MD, Qu Dawei, PhD, X. Lisa Yu, MD, S. Adamson Lee, PhD, John Sled, PhD, Freedman John, MD, Heyu Ni, MD PhD

Blood (2015) 126 (23): 2254.

https://doi.org/10.1182/blood.V126.23.2254.2254

Published: 2015

Journal Articles

Apolipoprotein Α-IV Is a Novel Ligand of Platelet αIIbβ3 Integrin and an Endogenous Thrombosis Inhibitor: Measurement of Single-Molecular Interactions By Biomembrane Force Probe

Blood (2014) 124 (21): 92.

https://doi.org/10.1182/blood.V124.21.92.92

Published: 2014

Journal Articles

Platelet Desialylation: A Novel Mechanism of Fc-Independent Platelet Clearance and a Potential Diagnostic Biomarker and Therapeutic Target in immune Thrombocytopenia

June Li, MSc, Dianne Evertdina van der Wal, PhD, Guangheng Zhu, MD, Miao Xu, MSc, MD, Issaka Yougbare, PhD, Li Ma, PhD, Brian Vadasz, BSc, Renata Grozovsky, PhD, Min Ruan, MD, Lingyan Zhu, MD, Qingshu Zeng, MD, Lili Tao, MD, Zhi-min Zhai, MD, Jun Peng, MD, Ming Hou, MD, Valery Leytin, PhD, John J. Freedman, MD, Karin M Hoffmeister, MD, Heyu Ni, MD PhD

Blood (2014) 124 (21): 467.

https://doi.org/10.1182/blood.V124.21.467.467

Published: 2014

Journal Articles

Response to TPO-Receptor Agonists: Role of Immature Platelet Fraction and Anti-GP1b

Alexandra Kruse, Alexa M. Sughroue, Patrick Morrissey, Claudia Tchatchouang, M.A., Guangheng Zhu, MD, Marina Izak, MD, Heyu Ni, MD PhD, James B. Bussel, MD

Blood (2014) 124 (21): 4190.

https://doi.org/10.1182/blood.V124.21.4190.4190

Published: 2014

Journal Articles

Unveiling the Regulatory Role of CD8+ T-Cells in the Pathogenesis and Effective Steroid Treatment in ITP

Li Ma, PhD, Elisa K. Simpson, MSc., June Li, MSc, Min Xuan, PhD, Miao Xu, MSc, MD, Laura Baker, BSc., Yan Shi, MD, Guangheng Zhu, MD, Pingguo Chen, MD PhD, Alan H Lazarus, PhD, John J. Freedman, MD, Heyu Ni, MD PhD

Blood (2014) 124 (21): 576.

https://doi.org/10.1182/blood.V124.21.576.576

Published: 2014

Journal Articles

Maternal Anti-Platelet β3 Integrin Antibodies Impair Angiogenesis and Cause Intracranial Hemorrhage in Fetal and Neonatal Alloimmune Thrombocytopenia

Blood (2014) 124 (21): 2772.

https://doi.org/10.1182/blood.V124.21.2772.2772

Published: 2014

Journal Articles

Novel Murine Models Of Fetal and Neonatal Alloimmune Thrombocytopenia Established In αIIb Deficient and Human αIIb Transgenic Mice

Brian Vadasz, BSc, Pingguo Chen, PhD, Yougbare Issaka, PhD, Guangheng Zhu, MD, Frampton Jonathan, Ph.D, Mortimer Poncz, MD, John J. Freedman, MD, Heyu Ni, MD, PhD

Blood (2013) 122 (21): 2314.

https://doi.org/10.1182/blood.V122.21.2314.2314

Published: 2013

Journal Articles

CD8+ T Cells Are Predominantly Protective In a Murine Model Of ITP and Is Required For Effective Steroid Therapy

Li Ma, Elisa K. Simpson, H.B.Sc., June Li, BSc, Guangheng Zhu, MD, Pingguo Chen, PhD, John W. Semple, PhD, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2013) 122 (21): 1076.

https://doi.org/10.1182/blood.V122.21.1076.1076

Published: 2013

Journal Articles

Psi Domain of b3 Integrin Has Endogenous Thiol Isomerase Function and Is a Potential New Target for Anti-Thrombotic Therapy

Guangheng Zhu, MD, Pingguo Chen, PhD, Adili Reheman, MD, June Li, BSc, Heyu Ni, MD, PhD

Blood (2012) 120 (21): 382.

https://doi.org/10.1182/blood.V120.21.382.382

Published: 2012

Journal Articles

Desialylation: A Novel Platelet Clearance Mechanism and a Potential New Therapeutic Target in Anti-GPIb Antibody Mediated Thrombocytopenia

Dianne E. van Der Wal, PhD, Guangheng Zhu, MD, June Li, BSc, Brian Vadasz, BSc, Yougbare Issaka, PhD, Sean Lang, MSc, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2012) 120 (21): 265.

https://doi.org/10.1182/blood.V120.21.265.265

Published: 2012

Journal Articles

Anthocyanins Inhibit Platelet Activation and Attenuate Thrombus Growth In Both Human and Murine Thrombosis Models

Yan Yang, MD, PhD, Zhenyin Shi, MD, Adili Reheman, MD, Wuxun Jin, MD, PhD, Conglei Li, MD, Guangheng Zhu, MD, Yiming Wang, MD, John J. Freedman, MD, Wenhua Ling, MD, PhD, Heyu Ni, MD, PhD

Blood (2010) 116 (21): 3197.

https://doi.org/10.1182/blood.V116.21.3197.3197

Published: 2010

Journal Articles

Steroids Are Less Effective In Treating Thrombocytopenia Caused by Immune Responses Against Platelet GPIbα: A Comparative Study Using Passive and Active ITP Models.

Elisa K. Simpson, H.B.Sc., Guangheng Zhu, MD, Conglei Li, MD, Lingyan Zhu, MD, Qingshu Zeng, MD, John W. Semple, PhD, John J. Freedman, MD, Heyu Ni, MD, PhD

Blood (2010) 116 (21): 1433.

https://doi.org/10.1182/blood.V116.21.1433.1433

Published: 2010

Journal Articles

Apolipoprotein AIV (ApoA-IV) Is a Novel Ligand of Platelet β3 Integrin That Negatively Regulates Platelet Adhesion, Aggregation, and Thrombosis.

Christopher M. Spring, MSc, Wuxun Jin, PhD, Hong Yang, MD, Adili Reheman, MD, Guangheng Zhu, MD, Yimin She, PhD, Terry Cyr, PhD, Patrick Tso, PhD, Sean Davidson, PhD, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2009) 114 (22): 156.

https://doi.org/10.1182/blood.V114.22.156.156

Published: 2009

Journal Articles

Novel Mouse Anti-Mouse β3 Integrin Monoclonal Antibodies: Development and Characterization of New Reagents for Research in Thrombosis and Thrombocytopenia.

Guangheng Zhu, MD, Michelle Lee Webster, MSc, Adili Reheman, MD, Pingguo Chen, MD, PhD, Ebrahim Sayeh, PhD, Hong Yang, MD, Ming Wang, MSc, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2007) 110 (11): 2107.

https://doi.org/10.1182/blood.V110.11.2107.2107

Published: 2007

NARROW

Targeting β3 Integrin Psi Domain Inhibits Both Platelet Aggregation and Blood Coagulation: Two Birds with One Stone

Antibodies Against Macrophage CD44 Protect Platelets from FcγR-Mediated Phagocytosis: A Potential Mechanism for CD44 Antibody Amelioration of Murine Immune Thrombocytopenia

Platelet GPIba Is Important for Thrombopoietin Production and Thrombopoietin-Induced Platelet Generation

Natural Killer Cells Contribute to Pathophysiology of Placenta Leading to Miscarriage in Fetal and Neonatal Alloimmune Thrombocytopenia

Apolipoprotein Α-IV Is a Novel Ligand of Platelet αIIbβ3 Integrin and an Endogenous Thrombosis Inhibitor: Measurement of Single-Molecular Interactions By Biomembrane Force Probe

Platelet Desialylation: A Novel Mechanism of Fc-Independent Platelet Clearance and a Potential Diagnostic Biomarker and Therapeutic Target in immune Thrombocytopenia

Response to TPO-Receptor Agonists: Role of Immature Platelet Fraction and Anti-GP1b

Unveiling the Regulatory Role of CD8+ T-Cells in the Pathogenesis and Effective Steroid Treatment in ITP

Maternal Anti-Platelet β3 Integrin Antibodies Impair Angiogenesis and Cause Intracranial Hemorrhage in Fetal and Neonatal Alloimmune Thrombocytopenia

Novel Murine Models Of Fetal and Neonatal Alloimmune Thrombocytopenia Established In αIIb Deficient and Human αIIb Transgenic Mice

CD8+ T Cells Are Predominantly Protective In a Murine Model Of ITP and Is Required For Effective Steroid Therapy

Psi Domain of b3 Integrin Has Endogenous Thiol Isomerase Function and Is a Potential New Target for Anti-Thrombotic Therapy

Desialylation: A Novel Platelet Clearance Mechanism and a Potential New Therapeutic Target in Anti-GPIb Antibody Mediated Thrombocytopenia

Anthocyanins Inhibit Platelet Activation and Attenuate Thrombus Growth In Both Human and Murine Thrombosis Models

Steroids Are Less Effective In Treating Thrombocytopenia Caused by Immune Responses Against Platelet GPIbα: A Comparative Study Using Passive and Active ITP Models.

Apolipoprotein AIV (ApoA-IV) Is a Novel Ligand of Platelet β3 Integrin That Negatively Regulates Platelet Adhesion, Aggregation, and Thrombosis.

Novel Mouse Anti-Mouse β3 Integrin Monoclonal Antibodies: Development and Characterization of New Reagents for Research in Thrombosis and Thrombocytopenia.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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