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Freda K Stevenson, DPhil
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Journal Articles

High Surface IgM Levels Associate with Shorter Response Duration and Bypass of the BTK Blockade during Ibrutinib Therapy in CLL Patients

Giorgia Chiodin, David Dutton, MD, Enrica Antonia Martino, MD, Samantha Drennan, PhD, Ian Tracy, PhD, Laura Ondrisova, Isla Henderson, Annalisa D'Avola, PhD, Christina Pitsillidou, Marek Mraz, MD, Peter Johnson, MDFRCP, Andrew Duncombe, MD, Graham Packham, PhD, Andrew J Steele, PhD, Helen Parker, PhD, Silvia Bonfiglio, Lydia Scarfo, MD, Lesley-Ann Sutton, Paolo Ghia, MD PhD, Matthew John Jerome Rose-Zerilli, PhD, Jonathan C Strefford, PhD, Freda K. Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2019) 134 (Supplement_1): 1752.
https://doi.org/10.1182/blood-2019-128899
Published: 2019
Journal Articles

PI3Kδ/AKT Inhibition Augments 2-Phenylethynesulfonamide Induced Apoptosis Via the Unfolded Protein Response in Chronic Lymphocytic Leukemia

Matthew D Blunt, PhD, Lindsay D Smith, PhD, Adam Linley, PhD BSc, Jonathan C Strefford, PhD, Peter Johnson, Francesco Forconi, MD DM, PhD FRCPath, Freda K. Stevenson, DPhil, Graham Packham, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4290.
https://doi.org/10.1182/blood.V130.Suppl_1.4290.4290
Published: 2017
Journal Articles

Regulation and Impact of BCR Induced Autophagy in Chronic Lymphocytic Leukemia

Lindsay D Smith, PhD, Laura I Karydis, PhD, Margaret Ashton-Key, MD, Jonathan C Strefford, PhD, Freda K. Stevenson, DPhil, Graham Packham, PhD, Mark Cragg, PhD, David A Tumbarello, PhD, Matthew D Blunt, PhD, Francesco Forconi, MD DM, PhD FRCPath, Andrew J Steele, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1717.
https://doi.org/10.1182/blood.V130.Suppl_1.1717.1717
Published: 2017
Journal Articles

Regulation of B-Cell Receptor Signalling By the Tumour Microenvironment in Chronic Lymphocytic Leukemia (CLL) and Its Impact on Adhesion and miRNA Expression

Matthew D Blunt, PhD, Rachel Dobson, BSc(Hons), Lindsay D Smith, PhD, Jonathan C. Strefford, Pamela B. Conley, PhD, Anjali Pandey, PhD, Andrew J Davies, FRCP PhD, Peter M Johnson, MA, MD, Graham Packham, PhD, Freda K Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath, Greg P Coffey, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2016) 128 (22): 351.
https://doi.org/10.1182/blood.V128.22.351.351
Published: 2016
Journal Articles

Global and MYC-Specific Translation Is Enhanced in Activated Chronic Lymphocytic Leukemia Cells Carrying NOTCH1 C.7541_7542delct Mutations

Annalisa D'Avola, MSc, Alison Yeomans, PhD, Samantha Drennan, PhD, Matthew Rose-Zerilli, PhD, Jonathan C. Strefford, Freda K Stevenson, DPhil, Andrew J Steele, PhD, Graham Packham, PhD, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2016) 128 (22): 970.
https://doi.org/10.1182/blood.V128.22.970.970
Published: 2016
Journal Articles

Early Enhancement of IgM Expression and Signaling Capacity during Ibrutinib Therapy in CLL Patients

Samantha Drennan, PhD, Giorgia Chiodin, MS, Annalisa D'Avola, MSc, Peter W Johnson, MD, Livio Trentin, MD, Graham Packham, PhD, Andrew J Steele, PhD, Freda K Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2016) 128 (22): 4381.
https://doi.org/10.1182/blood.V128.22.4381.4381
Published: 2016
Journal Articles

IL-10 Production By CLL Cells Is Enhanced in the Anergic IGHV Mutated Subset and Associates with Reduced DNA Methylation of the IL-10 Locus

Samantha Drennan, PhD, Annalisa D'Avola, MSc, Yifang Gao, PhD, Eleni Chrysostomou, MSc, Andrew J Steele, PhD, Thorsten Zenz, MD, Christoph Plass, PhD, Peter W Johnson, MD, Anthony P Williams, PhD FRCPath, Graham Packham, PhD, Freda K Stevenson, DPhil, Christopher C. Oakes, PhD, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2015) 126 (23): 2917.
https://doi.org/10.1182/blood.V126.23.2917.2917
Published: 2015
Journal Articles

Biological Significance of B Cell Receptor Mediated Regulation of Autophagy in Chronic Lymphocytic Leukemia

Lindsay Smith, PhD, Elizabeth Hogg, BSc(Hons), Angus Haynes, Jonathan C Strefford, PhD, Francesco Forconi, MD DM, PhD FRCPath, Freda K Stevenson, DPhil, Graham Packham, PhD, Mark S Cragg, PhD, David Tumbarello, Matthew D Blunt, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2015) 126 (23): 4130.
https://doi.org/10.1182/blood.V126.23.4130.4130
Published: 2015
Journal Articles

The Syk\Jak Inhibitor Cerdulatinib (PRT062070) Shows Promising Preclinical Activity in Chronic Lymphocytic Leukemia By Antagonising B Cell Receptor and Microenvironmental Signalling

Matthew D Blunt, PhD, Jack Parnell, BSc(hons), Marta Larrayoz, PhD, Lindsay Smith, PhD, Rachel Dobson, BSc(Hons), Jonathan C Strefford, PhD, Freda K Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath, Andrew J Davies, MRCP, Peter W Johnson, MD, Graham Packham, PhD, Greg P. Coffey, PhD, Mark S Cragg, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2015) 126 (23): 1716.
https://doi.org/10.1182/blood.V126.23.1716.1716
Published: 2015
Journal Articles

Increased Reactive Oxygen Species and the B-Cell Receptor in Chronic Lymphocytic Leukemia Signaling

Adam J Linley, PhD BSc, Beatriz Valle-Argos, PhD BSc, Andrew J Steele, PhD, Freda K Stevenson, DPhil, Francesco Forconi, Graham Packham, PhD
Journal: Blood
Blood (2014) 124 (21): 3291.
https://doi.org/10.1182/blood.V124.21.3291.3291
Published: 2014
Journal Articles

IL-4 Exerts Opposing Effects on Surface-IgM and CXCR4 Mediated Signalling in Chronic Lymphocytic Leukaemia

Maria Montserrat Aguilar, PhD, Matthew D Blunt, PhD, Jonathan C Strefford, PhD, Francesco Forconi, MD DM, PhD FRCPath, Mark Cragg, PhD, Freda K Stevenson, DPhil, Graham Packham, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2014) 124 (21): 3299.
https://doi.org/10.1182/blood.V124.21.3299.3299
Published: 2014
Journal Articles

The Dual PI3K/mTOR Inhibitor PF-04691502 Induces Substantial Apoptosis in Chronic Lymphocytic Leukemia Cells in Vitro and Prolongs Survival in the Eµ-TCL1 Mouse Model

Matthew D Blunt, PhD, Matthew J Carter, PhD, Marta Larrayoz, PhD, Maria Montserrat Aguilar, PhD, Sarah Murphy, Mark Reynolds, Thomas Tipton, Kerry Cox, Jonathan C Strefford, PhD, Freda K Stevenson, DPhil, Francesco Forconi, Graham Packham, PhD, Mark Cragg, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2014) 124 (21): 832.
https://doi.org/10.1182/blood.V124.21.832.832
Published: 2014
Journal Articles

Surface IgM Levels Independently Influence Clinical Behavior and Associate with Altered Phenotype and Genetics in Chronic Lymphocytic Leukemia

Samantha J Drennan, PhD, Annalisa D'Avola, MSc, Ian Tracy, Isla Henderson, Marta Larrayoz, PhD, Carina Mundy, Andrew S. Duncombe, MD, Andrew J. Davies, MD PhD, Davide Rossi, MD PhD, Fiona M Ross, DPhil, Laura Chiecchio, PhD, Kathleen N. Potter, PhD, Jonathan Strefford, PhD, Andrew J Steele, PhD, Peter W Johnson, MD, Graham Packham, PhD, Freda K Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2014) 124 (21): 830.
https://doi.org/10.1182/blood.V124.21.830.830
Published: 2014
Journal Articles

Modulation of B Cell Receptor Signalling By IL-4 In Chronic Lymphocytic Leukaemia

Maria Aguilar-Hernandez, PhD, Matthew D Blunt, PhD, Jonathan C Strefford, Andrew Duncombe, MD, Francesco Forconi, MD, PhD, Freda K. Stevenson, DPhil, Graham K Packham, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2013) 122 (21): 4125.
https://doi.org/10.1182/blood.V122.21.4125.4125
Published: 2013
Journal Articles

A “Universal” Lectin-Mediated Interaction Drives B-Cell Receptor Signaling In Primary Follicular Lymphoma Cells

Graham Packham, Serge Krysov, Vania Coelho, Peter Johnson, FRCP, Freda K. Stevenson, DPhil
Journal: Blood
Blood (2013) 122 (21): 4291.
https://doi.org/10.1182/blood.V122.21.4291.4291
Published: 2013
Journal Articles

Phenethyl Isothiocyanate (PEITC) Regulates Autophagy in Chronic Lymphocytic Leukemia.

Jemimah Adams, PhD, R Gitendra Wickremasinghe, PhD, Archibald G Prentice, MBChB, FRCP, FRCPath, Jonathan C. Strefford, BSc, PhD, Andrew Duncombe, MD, Francesco Forconi, MD, Freda K. Stevenson, DPhil, Graham Packham, PhD, Andrew Steele, PhD
Journal: Blood
Blood (2012) 120 (21): 2906.
https://doi.org/10.1182/blood.V120.21.2906.2906
Published: 2012
Journal Articles

B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia

Freda K. Stevenson, DPhil, Serge Krysov, Alex Paterson, Vania Coelho, Andrew Steele, PhD, Francesco Forconi, Graham Packham
Journal: Blood
Blood (2012) 120 (21): SCI-25.
https://doi.org/10.1182/blood.V120.21.SCI-25.SCI-25
Published: 2012
Journal Articles

IgM + B-Cells Lacking CD27 Expression Display Somatically Mutated Ig V H Genes and Define a New Memory Population.

Nicola J. Weston-Bell, PhD, Mark R. Townsend, BSc, Francesco Forconi, MD DM PhD, Freda K. Stevenson, DPhil FMedSci, Surinder S. Sahota, PhD
Journal: Blood
Blood (2007) 110 (11): 2630.
https://doi.org/10.1182/blood.V110.11.2630.2630
Published: 2007