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Deborah DeRyckere, PhD
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Journal Articles

Mertk Inhibition Promotes Anti-Leukemia Immunity By Reversing T Cell Suppression Via the PD-1 Axis

Alisa Lee-Sherick, MD, Kristen Jacobsen, PhD, Curtis J. Henry, PhD, Rebecca Parker, Xiaodong Wang, PhD, Stephen V Frye, PhD, H. Shelton Earp, MD, Deborah DeRyckere, PhD, Douglas K Graham, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4019.
https://doi.org/10.1182/blood-2018-99-119818
Published: 2018
Journal Articles

Bone Marrow Stromal Cell Mediated Resistance to Mertk Inhibition in Acute Myeloid Leukemia

Katherine A Minson, MD, Madeline G Huey, BA, Annie Qiu, Xiaodong Wang, PhD, Stephen V Frye, PhD, H. Shelton Earp, MD, Deborah DeRyckere, PhD, Douglas K Graham, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3823.
https://doi.org/10.1182/blood.V130.Suppl_1.3823.3823
Published: 2017
Journal Articles

Mertk Is a Therapeutic Target in Early T-Precursor Acute Lymphoblastic Leukemia

Ryan J Summers, MD, Katherine A Minson, MD, Stephen V Frye, PhD, Xiaodong Wang, PhD, H. Shelton Earp, III, MD, Deborah DeRyckere, PhD, Douglas K. Graham, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2536.
https://doi.org/10.1182/blood.V130.Suppl_1.2536.2536
Published: 2017
Journal Articles

Bone Marrow Stromal Cell Mediated Resistance to Mertk Inhibition in Acute Leukemia

Katherine A Minson, MD, Madeline G Huey, BS, Amanda A Hill, Irene Perez, Xiaodong Wang, PhD, Stephen Frye, PhD, H. Shelton Earp, III, MD, Deborah DeRyckere, PhD, Douglas K. Graham, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2819.
https://doi.org/10.1182/blood.V128.22.2819.2819
Published: 2016
Journal Articles

MRX2843, a Novel Dual MerTK-FLT3 Inhibitor with Activity Against Resistance-Conferring FLT3 Mutations in Acute Myeloid Leukemia

Katherine A Minson, MD, Catherine C Smith, MD, Alisa B. Lee-Sherick, MD, Deborah DeRyckere, PhD, Elisabeth Lasater, PhD, Amanda A. Hill, Xiaodong Wang, PhD, Stephen V. Frye, PhD, H. Shelton Earp, MD, Neil P. Shah, MD PhD, Douglas K. Graham, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3757.
https://doi.org/10.1182/blood.V124.21.3757.3757
Published: 2014
Journal Articles

UNC2025, a Small Molecule MerTK and Flt3 Tyrosine Kinase Inhibitor, Decreases Disease Burden, Prolongs Survival, and Promotes Sensitivity to Chemotherapy in Xenograft Models of Acute Leukemia

Deborah DeRyckere, PhD, Alisa B. Lee-Sherick, MD, Amanda A. Hill, Lauren Page, BS, Xiaodong Wang, PhD, Stephen V. Frye, PhD, H. Shelton Earp, MD, Douglas K. Graham, MD PhD
Journal: Blood
Blood (2014) 124 (21): 998.
https://doi.org/10.1182/blood.V124.21.998.998
Published: 2014
Journal Articles

Mer Receptor Tyrosine Kinase Is A Potential Therapeutic Target in Acute Myeloid Leukemia

Alisa B. Lee-Sherick, MD, Kelly Menachof, Kristen M. Eisenman, MD, Amy McGranahan, Colleen McGary, Sally A. Hunsucker, PhD, Jennifer Schlegel, Paul M Armistead, MD, PhD, Xiayuan Liang, MD, Dmitri Kireev, William Janzen, Jing Liu, Michael Stashko, Jacqueline Norris-Drouin, H. Shelton Earp, III, Xiaodong Wang, Stephen Frye, Deborah DeRyckere, PhD, Douglas K. Graham, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1317.
https://doi.org/10.1182/blood.V120.21.1317.1317
Published: 2012
Journal Articles

Evaluation of UNC569, a Novel Small Molecule Mer Inhibitor for the Treatment of ALL in Vitro and in Vivo.

Sandra Christoph, Deborah DeRyckere, PhD, Jennifer Schlegel, Susan Sather, BS, Amy McGranahan, J. Kimble Franzer, Alesia Trakhimets, Xiaodong Wang, Dmitri Kireev, William Janzen, Jing Liu, Chao Yang, Catherine Simpson, Jacqueline Norris-Drouin, Stephen Frye, H. Shelton Earp, III, Gary L. Johnson, Douglas K. Graham
Journal: Blood
Blood (2012) 120 (21): 2607.
https://doi.org/10.1182/blood.V120.21.2607.2607
Published: 2012
Journal Articles

UNC569 As Novel Small Molecule Mer Receptor Tyrosine Kinase Inhibitor for Treatment of ALL

Sandra Christoph, Deborah DeRyckere, PhD, Susan Sather, BS, Xiaodong Wang, Dmitri Kireev, William Janzen, Jing Liu, Chao Yang, Amy van Deusen, Catherine Simpson, Jacqueline Norris-Drouin, Stephen Frye, H. Shelton Earp, III, Gary L. Johnson, Douglas K. Graham
Journal: Blood
Blood (2011) 118 (21): 2589.
https://doi.org/10.1182/blood.V118.21.2589.2589
Published: 2011
Journal Articles

Mer Receptor Tyrosine Kinase Is Over-Expressed In and Contributes to Oncogenesis In Acute Myeloid Leukemia

Alisa B. Lee-Sherick, MD, Kristen M. Eisenman, MD, Susan Sather, BS, Deborah DeRyckere, PhD, Jennifer Schlegel, Douglas K. Graham, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1390.
https://doi.org/10.1182/blood.V118.21.1390.1390
Published: 2011
Journal Articles

Pre-Clinical Development of Suberoylanilide Hydroxamic Acid (SAHA, Vorinostat ™) for the Treatment of Pediatric Acute Leukemias.

Deborah DeRyckere, PhD, Timothy P. Garrington, MD, Lia Gore, MD
Journal: Blood
Blood (2006) 108 (11): 2277.
https://doi.org/10.1182/blood.V108.11.2277.2277
Published: 2006
Journal Articles

Lymphoblastic Leukemia/Lymphoma in Mice Overexpressing the Mer Receptor Tyrosine Kinase.

Dana B. Salzberg, MD, Amy K. Keating, MD, Adil Anwar, PhD, Kelly Sawczyn, MD, Kimberley Hill, Susan Sather, Jane Park, BS, Deborah DeRyckere, PhD, Doug Everett, PhD, Douglas K. Graham, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 2619.
https://doi.org/10.1182/blood.V106.11.2619.2619
Published: 2005