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Journal Articles

A Novel STAT3 Inhibitor Has Potent Activity in Preclinical Models of Acute Myeloid Leukemia That Incorporate the Stromal Environment

Michael J Krueger, BS, Matthew Minus, BS, Wei Liu, PhD, Xin Long, PhD, Alexandra M. Stevens, MD, Mikhail I. Kolosov, BS, Edward Allan R. Sison, MD, David John Tweardy, MD, Zachary T. Ball, PhD, Michele S. Redell, MD PhD

Blood (2015) 126 (23): 569.

https://doi.org/10.1182/blood.V126.23.569.569

Published: 2015

Journal Articles

Piperlongumine Blocks JAK2-STAT3 Pathway to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species

Hengjie Yuan, MD PhD, Katie Houck, BS, Ye Tian, MD PhD, Zhou Zhou, MDPhD, Mingzhao Zhu, Vimal Patel, Uddalak Bharadwaj, PhD, David John Tweardy, MD, Daniel Romo, PhD, Xiaoyun Fu, PhD, Yanjun Zhang, PhD, Jianning Zhang, MD PhD, Jing-fei Dong, MD PhD

Blood (2014) 124 (21): 2755.

https://doi.org/10.1182/blood.V124.21.2755.2755

Published: 2014

Journal Articles

A Small Molecule Stat Inhibitor Blocks Stat3 and Stat5 Phosphorylation and Demonstrates Cytotoxicity In Acute Lymphoblastic Leukemia

Robyn M. Dennis, MD, Brandon Ballard, David John Tweardy, MD, Karen Rabin, MD

Blood (2010) 116 (21): 2904.

https://doi.org/10.1182/blood.V116.21.2904.2904

Published: 2010

Journal Articles

Multiparameter FACS Analysis of G-CSF and IL-6 Signaling through Stat3 and Stat5 In Primary Pediatric AML Samples.

Michele S. Redell, MD, PhD, Marcos J. Ruiz, BS, Robert B. Gerbing, Todd A. Alonzo, PhD, David John Tweardy, MD

Blood (2010) 116 (21): 1051.

https://doi.org/10.1182/blood.V116.21.1051.1051

Published: 2010

Journal Articles

3-D Pharmacophore Identification of Second Generation Small Molecule Inhibitors of Stat3 SH2-Phosphotyrosine Binding That Induce Apoptosis in Acute Myeloid Leukemia Cells.

Redell S. Redell, MD, PhD, Xuejun Xu, PhD, Moses M. Kasembeli, PhD, Marcos J. Ruiz, David John Tweardy, MD

Blood (2009) 114 (22): 1727.

https://doi.org/10.1182/blood.V114.22.1727.1727

Published: 2009

Journal Articles

Wild-Type and Mutant C-Kit Activation of Stat3α Contribute to Leukemogenesis through Distinct Effects on Myeloid Cell Proliferation and Resistance to Apoptosis

Michele Redell, MD, PhD, Marcos J. Ruiz, David John Tweardy, MD

Blood (2008) 112 (11): 5317.

https://doi.org/10.1182/blood.V112.11.5317.5317

Published: 2008

Journal Articles

Stat3 Isoforms, α and β, Demonstrate Distinct Intracellular Dynamics: Prolonged Nuclear Retention of Stat3β Maps to Its Unique C-Terminal End.

David John Tweardy, MD, Ying Huang, BS

Blood (2006) 108 (11): 4348.

https://doi.org/10.1182/blood.V108.11.4348.4348

Published: 2006

Journal Articles

Overexpression of Stat3α, but Not Statβ, in Myeloid Cells Results in Neutrophil Expansion through Reduced Apoptosis and Modulation of a Unique Set of Apoptosis Pathway Genes.

Michele Redell, MD, PhD, Anna Tsimelzon, PhD, Susan G. Hilsenbeck, PhD, David John Tweardy, MD

Blood (2006) 108 (11): 1147.

https://doi.org/10.1182/blood.V108.11.1147.1147

Published: 2006

Journal Articles

Aberrant Chromatin Remodeling by APL Fusion Proteins Assessed at the Single-Cell Level: Contribution of Reduced Mobility of Nuclear Coregulators.

David John Tweardy, MD, Jihui Qui, PhD, Ying Huang, BS, Shuo Dong, PhD

Blood (2006) 108 (11): 2069.

https://doi.org/10.1182/blood.V108.11.2069.2069

Published: 2006

Journal Articles

Structural Determinants for Signal Transducer and Activator of Transcription (STAT) 3 Recruitment and Activation by the Granulocyte Colony-Stimulating Factor Receptor (G-CSFR) at Phosphotyrosine Ligands 704 and 744.

David John Tweardy, MD, Xu Xuejun, PhD, Naijie Jing, PhD, Huang Shao, PhD

Blood (2004) 104 (11): 2169.

https://doi.org/10.1182/blood.V104.11.2169.2169

Published: 2004

NARROW

A Novel STAT3 Inhibitor Has Potent Activity in Preclinical Models of Acute Myeloid Leukemia That Incorporate the Stromal Environment

Piperlongumine Blocks JAK2-STAT3 Pathway to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species

A Small Molecule Stat Inhibitor Blocks Stat3 and Stat5 Phosphorylation and Demonstrates Cytotoxicity In Acute Lymphoblastic Leukemia

Multiparameter FACS Analysis of G-CSF and IL-6 Signaling through Stat3 and Stat5 In Primary Pediatric AML Samples.

3-D Pharmacophore Identification of Second Generation Small Molecule Inhibitors of Stat3 SH2-Phosphotyrosine Binding That Induce Apoptosis in Acute Myeloid Leukemia Cells.

Wild-Type and Mutant C-Kit Activation of Stat3α Contribute to Leukemogenesis through Distinct Effects on Myeloid Cell Proliferation and Resistance to Apoptosis

Stat3 Isoforms, α and β, Demonstrate Distinct Intracellular Dynamics: Prolonged Nuclear Retention of Stat3β Maps to Its Unique C-Terminal End.

Overexpression of Stat3α, but Not Statβ, in Myeloid Cells Results in Neutrophil Expansion through Reduced Apoptosis and Modulation of a Unique Set of Apoptosis Pathway Genes.

Aberrant Chromatin Remodeling by APL Fusion Proteins Assessed at the Single-Cell Level: Contribution of Reduced Mobility of Nuclear Coregulators.

Structural Determinants for Signal Transducer and Activator of Transcription (STAT) 3 Recruitment and Activation by the Granulocyte Colony-Stimulating Factor Receptor (G-CSFR) at Phosphotyrosine Ligands 704 and 744.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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