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Journal Articles

Safety and Efficacy of the Contact Activation Inhibitor AB023 in Patients with End-Stage Renal Disease on Chronic Hemodialysis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial

Christina U Lorentz, PhD, Norah G Verbout, PhD, Joseph J Shatzel, MD, Michael Wallisch, PhD, Brandon D Markway, PhD, Monica T Hinds, PhD, Owen J T McCarty, PhD, David Gailani, MD, Jeffrey I. Weitz, MDFRCPC, Erik I Tucker, PhD, András Gruber, MD

Blood (2020) 136 (Supplement 1): 23–24.

https://doi.org/10.1182/blood-2020-139948

Published: 2020

Journal Articles

Coagulation Factor XI and Factor XII in DNA-Induced Thrombin Generation

Anton Matafonov, MD, Ivan S. Ivanov, PhD, Mao-fu Sun, David Gailani, MD

Blood (2014) 124 (21): 581.

https://doi.org/10.1182/blood.V124.21.581.581

Published: 2014

Journal Articles

Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

Harry Roger Buller, MD PhD, Claudette Bethune, PhD, Sanjay Bhanot, MDPhD, David Gailani, MD, Brett P. Monia, PhD, Gary E. Raskob, PhD, Annelise Segers, Peter Verhamme, MD PhD, Jeffrey I. Weitz, MDFRCPC

Blood (2014) 124 (21): LBA-1.

https://doi.org/10.1182/blood.V124.21.LBA-1.LBA-1

Published: 2014

Journal Articles

Factor XI Deficiency Reduces The Inflammatory Response To Polymicrobial Sepsis In Mice

Charles E. Bane, jr., DVM, Kelli L. Boyd, DVM, Ph.D., Erik I. Tucker, Ph.D., Stephen T. Smiley, Ph.D., Andras Gruber, MD, David Gailani, MD

Blood (2013) 122 (21): 201.

https://doi.org/10.1182/blood.V122.21.201.201

Published: 2013

Journal Articles

Antibodies to Human Factor XII with Antithrombotic Properties

Anton Matafonov, MD, Adam E. Gailani, Stephanie L. Grach, Philberta Y Leung, PhD, Qiufang Cheng, MD, Yipeng Geng, Owen J.T. McCarty, PhD, Erik I Tucker, PhD, Thomas Renne, MD, PhD, James H. Morrissey, PhD, Andras Gruber, MD, David Gailani, MD

Blood (2012) 120 (21): 1106.

https://doi.org/10.1182/blood.V120.21.1106.1106

Published: 2012

Journal Articles

FXII Promotes Coagulation in a FXI and FIX Independent Manner

Cristina Puy, PhD, Zoë C Wong, Erik I Tucker, PhD, Andras Gruber, MD, David Gailani, MD, Stephanie A. Smith, DVM, MS, Sharon H. Choi, MS, James H. Morrissey, PhD, Owen J.T. McCarty, PhD

Blood (2012) 120 (21): 3362.

https://doi.org/10.1182/blood.V120.21.3362.3362

Published: 2012

Journal Articles

The Interaction of Coagulation Factor XI with Polyphosphate

Yipeng Geng, Ingrid M. Verhamme, PhD, Qiufang Cheng, MD, Anton Matafonov, MD, Stephen B. Smith, PhD, Mao-fu Sun, Stephanie A. Smith, DVM, MS, James H. Morrissey, PhD, David Gailani, MD

Blood (2012) 120 (21): 498.

https://doi.org/10.1182/blood.V120.21.498.498

Published: 2012

Journal Articles

Antisense Oligonucleotide Mediated Depletion of Factor XI Prevents Vascular Occlusion in An Experimental Thrombosis Model in Primates

Jeff R. Crosby, PhD, Ulla M Marzec, MS, Chenguang Zhao, Dacao Gao, Alexey S Revenko, PhD, Anton Matafonov, MD, David Gailani, MD, Robert MacLeod, Ph.D., Andras Gruber, MD, Stephen Hanson, PhD, Brett P. Monia, PhD

Blood (2011) 118 (21): 2250.

https://doi.org/10.1182/blood.V118.21.2250.2250

Published: 2011

Journal Articles

Deficiency in Plasminogen Cause Decreased Vascularity in Sold Tissue Organs and Bone

Nicholas Mignemi, Heather Cole, Masato Yausa, M.D., David Gailani, MD, Jay L. Degen, PhD, Jonathan G Schoenecker, MD PhD

Blood (2011) 118 (21): 857.

https://doi.org/10.1182/blood.V118.21.857.857

Published: 2011

Journal Articles

Apple Domain-Specific Anti-Factor XI Antibodies Inhibit Venous-Type Thrombosis with Improved Hemostatic Safety Profiles Compared to Enoxaparin in Primates

Erik I. Tucker, PhD, Ulla M Marzec, MS, Philberta Y Leung, PhD, Stephen R Hanson, PhD, Prof., Norah G Verbout, PhD, Sawan Hurst, MS, Owen J.T. McCarty, PhD, David Gailani, MD, Andras Gruber, MD

Blood (2011) 118 (21): 1173.

https://doi.org/10.1182/blood.V118.21.1173.1173

Published: 2011

Journal Articles

Coagulation Cofactor Presentation and Complex Assembly on Platelets by Protease Activated Receptors (PARs): PAR4 Stimulation Leads to More FV and FVIII and More Thrombin Generation Than PAR1

Matthew T Duvernay, PhD, Summer E Young, BS, David Gailani, MD, Jonathan G Schoenecker, MD PhD, Heidi Hamm, PhD

Blood (2011) 118 (21): 1135.

https://doi.org/10.1182/blood.V118.21.1135.1135

Published: 2011

Journal Articles

Exosite Interactions in Factor IX Activation by Factor XIa

Yipeng Geng, Ingrid M. Verhamme, PhD, Stephen B. Smith, PhD, Amanda S. Messer, Mao-fu Sun, S. Paul Bajaj, David Gailani, MD

Blood (2011) 118 (21): 2235.

https://doi.org/10.1182/blood.V118.21.2235.2235

Published: 2011

Journal Articles

Evidence for a Factor IX-Independent Role for Factor XI in Thrombin Generation

Anton Matafonov, MD, Qiufang Cheng, MD, Ingrid M. Verhamme, PhD, Obi Umunakwe, Erik I. Tucker, PhD, Mao-fu Sun, Andras Gruber, MD, David Gailani, MD

Blood (2011) 118 (21): 2244.

https://doi.org/10.1182/blood.V118.21.2244.2244

Published: 2011

Journal Articles

New Insights Into Factor XI Function: From Biochemistry to Animal Models

David Gailani, MD

Blood (2010) 116 (21): SCI-20.

https://doi.org/10.1182/blood.V116.21.SCI-20.SCI-20

Published: 2010

Journal Articles

Factor XI Inhibitor Antibody Treatment Improves Survival In a Murine Polymicrobial Sepsis Model

Erik I Tucker, PhD, Melani Helm, BS, Owen JT McCarty, PhD, Sawan Hurst, MS, David Gailani, MD, Andras Gruber, MD

Blood (2010) 116 (21): 820.

https://doi.org/10.1182/blood.V116.21.820.820

Published: 2010

Journal Articles

Activation of Factor XI and the Contact Proteases by Products of Prothrombin Activation.

Anton Matafonov, MD, Suryakala Sarilla, PhD, Mao-fu Sun, John P. Sheehan, MD, Vladimir Serebrov, MD, PhD, DMSci, Ingrid Verhamme, PhD, David Gailani, MD

Blood (2010) 116 (21): 1150.

https://doi.org/10.1182/blood.V116.21.1150.1150

Published: 2010

Journal Articles

Identification of a Role for Apolipoprotein E Receptor 2 as a Platelet Receptor for Factor XI

Tara C White, Michelle A Berny, Erik I Tucker, Jiaqing Pang, David Gailani, MD, Rolf T Urbanus, MD, Philip G de Groot, PhD, András Gruber, MD, Owen JT McCarty, PhD

Blood (2008) 112 (11): 3914.

https://doi.org/10.1182/blood.V112.11.3914.3914

Published: 2008

Journal Articles

Characterization of Heparin Binding Site Residues on the Catalytic Domain of Factor XIa

Likui Yang, Ph.D., Mao-fu Sun, Chandrashekhara Manithody, Ph.D., David Gailani, MD, Alireza R. Rezaie, PhD

Blood (2008) 112 (11): 1018.

https://doi.org/10.1182/blood.V112.11.1018.1018

Published: 2008

Journal Articles

Independence of Factor XIa Subunits in Factor IX Activation.

Stephen B. Smith, BS, Mao-fu Sun, BS, Paul E. Bock, PhD, David Gailani, MD

Blood (2006) 108 (11): 334.

https://doi.org/10.1182/blood.V108.11.334.334

Published: 2006

Journal Articles

Factor XI Deficiency Confers a Survival Advantage in a Murine Sepsis Model.

David Gailani, MD, Erik I. Tucker, BS, Qiufang Cheng, MD, Stephen R. Hanson, PhD, Andras Gruber, MD

Blood (2006) 108 (11): 1005.

https://doi.org/10.1182/blood.V108.11.1005.1005

Published: 2006

NARROW

Safety and Efficacy of the Contact Activation Inhibitor AB023 in Patients with End-Stage Renal Disease on Chronic Hemodialysis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial

Coagulation Factor XI and Factor XII in DNA-Induced Thrombin Generation

Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

Factor XI Deficiency Reduces The Inflammatory Response To Polymicrobial Sepsis In Mice

Antibodies to Human Factor XII with Antithrombotic Properties

FXII Promotes Coagulation in a FXI and FIX Independent Manner

The Interaction of Coagulation Factor XI with Polyphosphate

Antisense Oligonucleotide Mediated Depletion of Factor XI Prevents Vascular Occlusion in An Experimental Thrombosis Model in Primates

Deficiency in Plasminogen Cause Decreased Vascularity in Sold Tissue Organs and Bone

Apple Domain-Specific Anti-Factor XI Antibodies Inhibit Venous-Type Thrombosis with Improved Hemostatic Safety Profiles Compared to Enoxaparin in Primates

Coagulation Cofactor Presentation and Complex Assembly on Platelets by Protease Activated Receptors (PARs): PAR4 Stimulation Leads to More FV and FVIII and More Thrombin Generation Than PAR1

Exosite Interactions in Factor IX Activation by Factor XIa

Evidence for a Factor IX-Independent Role for Factor XI in Thrombin Generation

New Insights Into Factor XI Function: From Biochemistry to Animal Models

Factor XI Inhibitor Antibody Treatment Improves Survival In a Murine Polymicrobial Sepsis Model

Activation of Factor XI and the Contact Proteases by Products of Prothrombin Activation.

Identification of a Role for Apolipoprotein E Receptor 2 as a Platelet Receptor for Factor XI

Characterization of Heparin Binding Site Residues on the Catalytic Domain of Factor XIa

Independence of Factor XIa Subunits in Factor IX Activation.

Factor XI Deficiency Confers a Survival Advantage in a Murine Sepsis Model.

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American Society of Hematology

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American Society of Hematology

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