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Daisuke Hasegawa, MD, PhD
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Journal Articles

Etoposide, Cytarabine and Mitoxantrone- or Fludarabine, Cytarabine and Granulocyte Colony-Stimulating Factor-Based Intensive Reinduction Chemotherapy Is Recommended for Children with Relapsed Acute Myeloid Leukemia: The Results from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05R Study

Hiroshi Moritake, MD PhD, Shiro Tanaka, PhD, Takako Miyamura, MD PhD, Hideki Nakayama, MD, Norio Shiba, MD PhD, Akira Shimada, MDPhD, Kiminori Terui, MD PhD, Yuki Yuza, MD PhD, Katsuyoshi Koh, MD, Hiroaki Goto, MD, PhD, Harumi Kakuda, MD PhD, Akiko M Saito, MD PhD, Daisuke Hasegawa, MD PhD, Shotaro Iwamoto, MD, Takashi Taga, MD PhD, Souichi Adachi, MD PhD, Daisuke Tomizawa, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6.
https://doi.org/10.1182/blood-2020-133272
Published: 2020
Journal Articles

Comprehensive Genetic Analysis Revealed Myeloid/Natural Killer (NK) Cell Precursor Acute Leukemia As a Novel Distinctive Leukemia Entity

Akira Nishimura, MD, Kazuaki Yokoyama, MD PhD, Chika Yamagishi, MD, Toshihiko Imamura, MD PhD, Takuya Naruto, MD PhD, Tomohiro Morio, MD PhD, Yukie Tanaka, PhD, Akinori Kanai, PhD, Hirotaka Matsui, MD PhD, Naoko Higuchi, MD, Akiko Takada, MD, Haruna Okuno, MD, Shoji Saito, MD PhD, Shuhei Karakawa, MD PhD, Shogo Kobayashi, MD, Daisuke Hasegawa, MD PhD, Hiroyuki Fujisaki, MD PhD, Daiichiro Hasegawa, MD PhD, Kazutoshi Koike, MD PhD, Takashi Koike, MD, Shinya Rai, MD PhD, Katsutsugu Umeda, MD PhD, Hideki Sano, MD, Yujin Sekinaka, MD PhD, Atsushi Ogawa, MD PhD, Akitoshi Kinoshita, MD PhD, Norio Shiba, MD PhD, Mizuka Miki, MD, Fumihiko Kimura, MD PhD, Hideki Nakayama, MD, Yozo Nakazawa, MD PhD, Takashi Taga, MD PhD, Tomohiko Taki, MD PhD, Souichi Adachi, MD PhD, Atsushi Manabe, MD PhD, Katsuyoshi Koh, MD, Yasushi Ishida, MD PhD, Arinobu Tojo, MD PhD, Masatoshi Takagi, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14–15.
https://doi.org/10.1182/blood-2020-139312
Published: 2020
Journal Articles

Predictive Factors of the Development of Leukemia in Patients with Transient Abnormal Myelopoiesis and Down Syndrome: The Jccg Study JPLSG TAM-10

Genki Yamato, MD PhD, Hideki Muramatsu, MD PhD, Tomoyuki Watanabe, PhD, Takao Deguchi, MD PhD, Shotaro Iwamoto, MD, Daisuke Hasegawa, MD PhD, Kiminori Terui, MD PhD, Takahiro Ueda, MD PhD, Tomoko Yokosuka, Tsutomu Toki, PhD, Shiro Tanaka, PhD, Ryu Yanagisawa, Katsuyoshi Koh, MD, Akiko M Saito, MD PhD, Keizo Horibe, MD PhD, Yasuhide Hayashi, MD PhD, Souichi Adachi, MD PhD, Shuki Mizutani, Takashi Taga, MD PhD, Etsuro Ito, MD PhD, Kenichiro Watanabe, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3833.
https://doi.org/10.1182/blood-2019-125465
Published: 2019
Journal Articles

Post-Induction Minimal Residual Disease Measured By Flow Cytometry and Deep Sequencing of Mutant GATA1 Are Both Significant Prognostic Factors for Children with Myeloid Leukemia and Down Syndrome: A Nationwide Prospective Study of the Japanese Pediatric Leukemia/Lymphoma Study Group

Takashi Taga, MD PhD, Shiro Tanaka, PhD, Kiminori Terui, MD PhD, Shotaro Iwamoto, MD, Hidefumi Hiramatsu, MD PhD, Takako Miyamura, MD PhD, Yoshiko Hashii, MD PhD, Daisuke Hasegawa, MD PhD, Hiroshi Moritake, MD PhD, Hideki Nakayama, MD, Hiroyuki Takahashi, MD PhD, Akira Shimada, MD PhD, Tomohiko Taki, MD PhD, Tsutomu Toki, PhD, Etsuro Ito, MD PhD, Katsuyoshi Koh, MD, Daiichiro Hasegawa, MD PhD, Asahito Hama, MD PhD, Akiko M Saito, MD PhD, Souichi Adachi, MD PhD, Daisuke Tomizawa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3848.
https://doi.org/10.1182/blood-2019-123302
Published: 2019
Journal Articles

NUDT15 Genetic Variation Is the Strongest Predictive Marker of Tolerance to 6-Mercaptopurine in Japanese Childhood ALL Patients: A Genome-Wide Association Study

Yoichi Tanaka, PhD, Kevin Y Urayama, PhD MPH, Makiko Mori, MD, Daisuke Hasegawa, MD PhD, Yasushi Noguchi, MD, Masakatsu Yanagimachi, MD PhD, Dai Keino, MD PhD, Setsuo Ota, MD PhD, Koshi Akahane, MD PhD, Mayumi Hangai, MD, Takahisa Kawaguchi, Masatoshi Takagi, MD PhD, Katsuyoshi Koh, MD, Fumihiko Matsuda, Atsushi Manabe, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1347.
https://doi.org/10.1182/blood-2019-129440
Published: 2019
Journal Articles

Tolerable Dose of 6-Mercaptopurine and Prognostic Impact of NUDT15-Deficient Genotype in Childhood Acute Lymphoblastic Leukemia

Yoichi Tanaka, PhD, Motohiro Kato, MD PhD, Takaya Moriyama, MD PhD, Yuki Arakawa, MD, Daisuke Hasegawa, MD PhD, Junya Fujimura, MD PhD, Dai Keino, MD PhD, Atsushi Sato, MD, Takahiro Ueda, MD PhD, Yuichi Taneyama, MD, Masatoshi Takagi, MD PhD, Masaki Yamamoto, MD, Masaki Matsuoka, MD, Moeko Hino, MD, Hiroki Hori, MD PhD, Katsuyoshi Koh, MD, Allen Eng Juh Yeoh, MD, Jun J. Yang, PhD, Atsushi Manabe, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4032.
https://doi.org/10.1182/blood-2018-99-114290
Published: 2018
Journal Articles

Clinical and Genetic Characteristics of Patients with Shwachman-Diamond Syndrome in Japan

Kenichiro Watanabe, MD PhD, Hirokazu Kanegane, MD PhD, Takayuki Hamabata, MD, Kagehiro Kozuki, MD, Katsutsugu Umeda, MD, PhD, Hiroo Ueno, MD, Kenichi Yoshida, MD PhD, Asahito Hama, Yusuke Okuno, MD PhD, Hideki Muramatsu, MD PhD, Yoshiyuki Takahashi, MD, PhD, Daisuke Hasegawa, MD PhD, Atsushi Manabe, MD PhD, Akira Ohara, MD, Masafumi Ito, MD PhD, Seishi Ogawa, MD PhD, Seiji Kojima, MD PhD, Etsuro Ito, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3862.
https://doi.org/10.1182/blood-2018-99-114313
Published: 2018
Journal Articles

Clinical Feature and Genetic Alterations in Myeloid/Natural Killer (NK) Cell Precursor Acute Leukemia and Myeloid/NK Cell Acute Leukemia

Akira Nishimura, MD, Kazuaki Yokoyama, MD PhD, Chika Yamagishi, MD, Takuya Naruto, MD PhD, Tomohiro Morio, MD PhD, Akinori Kanai, PhD, Hirotaka Matsui, MD PhD, Naoko Higuchi, MD, Akiko Takada, MD, Haruna Okuno, MD, Shoji Saito, MD, Shuhei Karakawa, MD, Shogo Kobayashi, MD, Hideki Sano, MD, Takashi Koike, MD, Daisuke Hasegawa, MD PhD, Hiroyuki Fujisaki, MD, PhD, Daiichiro Hasegawa, MD PhD, Kazutoshi Koike, MD, Atsushi Ogawa, MD PhD, Akitoshi Kinoshita, MD PhD, Norio Shiba, MD PhD, Mizuka Miki, MD, Hideki Nakayama, MD, Yozo Nakazawa, MD, PhD, Toshihiko Imamura, MD PhD, Takashi Taga, MD PhD, Souichi Adachi, MD PhD, Katsuyoshi Koh, MD, Atsushi Manabe, MD PhD, Tomohiko Taki, MD PhD, Yasushi Ishida, MD PhD, Arinobu Tojo, MD PhD, Masatoshi Takagi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2824.
https://doi.org/10.1182/blood-2018-99-118627
Published: 2018
Journal Articles

Nationwide Survey of Pediatric Hypodiploid Acute Lymphoblastic Leukemia in Japan

Sae Ishimaru, MD, Yasuhiro Okamoto, MD, Chihaya Imai, MD PhD, Hirotoshi Sakaguchi, MD PhD, Tomohiko Taki, MD PhD, Daisuke Hasegawa, MD PhD, Yuko Cho, MD, Harumi Kakuda, MD PhD, Hideki Sano, MD, Atushi Manabe, MD PhD, Toshihiko Imamura, MD, PhD, Motohiro Kato, MD, Yuki Arakawa, MD, Hidemi Shimonodan, MD, Atsushi Sato, MD, So-ichi Suenobu, MD PhD, Takeshi Inukai, MD, Arata Watanabe, MD, Yoshifumi Kawano, MD PhD, Atsushi Kikuta, MD, Keizo Horibe, Akira Ohara, MD, Katsuyoshi Koh, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5121.
https://doi.org/10.1182/blood.V130.Suppl_1.5121.5121
Published: 2017
Journal Articles

Analysis of GATA1 Mutations in Down Syndrome Infants with Transient Abnormal Myelopoiesis and Clinical Impacts of GATA1 Mutation Types: A Report from the JPLSG TAM-10 Study

Kiminori Terui, MD PhD, Tsutomu Toki, PhD, Asahito Hama, MD PhD, Hideki Muramatsu, MD PhD, Daisuke Hasegawa, MD PhD, Myoung-Ja Park, MD PhD, Shotaro Iwamoto, MD PhD, Takashi Taga, MD PhD, Ryu Yanagisawa, MD PhD, Katsuyoshi Koh, MD, Akiko M. Saito, MD PhD, Keizo Horibe, MD PhD, Yasuhide Hayashi, MD PhD, Souichi Adachi, MD, PhD, Shuki Mizutani, MD, PhD, Kenichiro Watanabe, MD PhD, Etsuro Ito, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2865.
https://doi.org/10.1182/blood.V128.22.2865.2865
Published: 2016
Journal Articles

The Association Between L-Asparaginase Hypersensitivity and Genetic Variants in Japanese Childhood ALL Patients

Yoichi Tanaka, PhD, Kevin Y Urayama, PhD MPH, Takahisa Kawaguchi, PhD, Makiko Mori, MD, Daisuke Hasegawa, MD PhD, Sae Ishimaru, MD, Yuichi Taneyama, MD PhD, Kazuki Terada, MD, Masakatsu Yanagimachi, MD PhD, Setsuo Ota, MD, Hiroyuki Takahashi, MD PhD, Takeshi Inukai, MD,PhD, Daisuke Toyama, MD, Dai Keino, MD PhD, Koichi Moriwaki, MD, Masatoshi Takagi, MD PhD, Junya Fujimura, MD, Yujin Sekinaka, MD, Kozue Nakamura, MD, Yuya Sato, MD, Keitaro Matsuo, MDPhD, Akira Ohara, MD PhD, Katsuyoshi Koh, MD, Fumihiko Matsuda, MD PhD, Atsushi Manabe, MD PhD
Journal: Blood
Blood (2016) 128 (22): 5141.
https://doi.org/10.1182/blood.V128.22.5141.5141
Published: 2016
Journal Articles

Comparison of Clinical Outcomes Between Pediatric Aplastic Anemia and Refractory Cytopenia of Childhood

Asahito Hama, MD PhD, Atsushi Manabe, MD PhD, Daisuke Hasegawa, MD PhD, Kazue Nozawa, Atsushi Narita, MD PhD, Hideki Muramatsu, MD PhD, Yoshiyuki Takahashi, MD PhD, Kenichiro Watanabe, MD PhD, Akira Ohara, MD PhD, Masafumi Ito, MD PhD, Seiji Kojima, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1498.
https://doi.org/10.1182/blood.V128.22.1498.1498
Published: 2016
Journal Articles

Prospective Study of 168 Infants with Transient Abnormal Myelopoiesis with Down Syndrome: Japan Pediatric Leukemia/Lymphoma Study Group, TAM-10 Study

Hideki Muramatsu, MD PhD, Tomoyuki Watanabe, Daisuke Hasegawa, MD PhD, Park Myoung-ja, Shotaro Iwamoto, Takashi Taga, MD PhD, Etsuro Ito, MD PhD, Tsutomu Toki, PhD, Kiminori Terui, Ryu Yanagisawa, Katsuyoshi Koh, MD PhD, Akiko M. Saito, Keizo Horibe, MD PhD, Yasuhide Hayashi, MD PhD, Souichi Adachi, MD PhD, Shuki Mizutani, MD PhD, Kenichiro Watanabe
Journal: Blood
Blood (2015) 126 (23): 1311.
https://doi.org/10.1182/blood.V126.23.1311.1311
Published: 2015
Journal Articles

Comparison of Clinical and Laboratory Features Between Pediatric Aplastic Anemia and Refractory Cytopenia of Childhood

Asahito Hama, MD PhD, Atsushi Manabe, MD PhD, Daisuke Hasegawa, MD PhD, Hideki Muramatsu, MD PhD, Yoshiyuki Takahashi, MD PhD, Kenichiro Watanabe, Akira Ohara, MD PhD, Masafumi Ito, MD PhD, Seiji Kojima, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1213.
https://doi.org/10.1182/blood.V126.23.1213.1213
Published: 2015
Journal Articles

Distinct Clinical and Cytogenetic Characteristics and Poor Prognosis in Children with Acute Erythroid Leukemia: A Report from the JPLSG AML-05 Study

Daisuke Tomizawa, MD PhD, Akio Tawa, MD PhD, Nobutaka Kiyokawa, MDPhD, Akitoshi Kinoshita, MD PhD, Hayato Miyachi, MD PhD, Yuka Yamashita, MS, Keizo Horibe, MD PhD, Shotaro Iwamoto, MD PhD, Takao Deguchi, MD PhD, Norio Shiba, MD PhD, Hiroshi Moritake, MD PhD, Akira Shimada, MD PhD, Daisuke Hasegawa, MD PhD, Takashi Taga, MD PhD, Eiichi Ishii, MD PhD, Souichi Adachi, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4945.
https://doi.org/10.1182/blood.V126.23.4945.4945
Published: 2015
Journal Articles

Genetic Susceptibility Loci for Childhood Acute Lymphoblastic Leukemia Among Japanese

Kevin Y Urayama, PhD MPH, Masatoshi Takagi, MD PhD, Takahisa Kawaguchi, PhD, Keitaro Matsuo, MDPhD, Yoichi Tanaka, PhD, Yuki Arakawa, MD, Daisuke Hasegawa, MD PhD, Yuki Yuza, MD PhD, Takashi Kaneko, MD PhD, Yasushi Noguchi, MD PhD, Yuichi Taneyama, MD PhD, Setsuo Ota, MD, Takeshi Inukai, MD PhD, Masakatsu Yanagimachi, MD PhD, Dai Keino, MDPhD, Kazutoshi Koike, MD, Daisuke Toyama, MD, Yozo Nakazawa, MD PhD, Hidemitsu Kurosawa, MD, Kozue Nakamura, MD, Koichi Moriwaki, MD, Hiroaki Goto, MD PhD, Yujin Sekinaka, MD, Daisuke Morita, MD, Motohiro Kato, MD PhD, Katsuyoshi Koh, MD PhD, Yasushi Ishida, MDPhD, Akira Ohara, MD PhD, Shuki Mizutani, MD PhD, Fumihiko Matsuda, MD PhD, Atsushi Manabe, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3731.
https://doi.org/10.1182/blood.V126.23.3731.3731
Published: 2015
Journal Articles

Long-Term Outcome of Six Months Maintenance Chemotherapy for ALL in Children: An Extended Follow up Study of TCCSG L92-13

Motohiro Kato, Atsushi Manabe, MD PhD, Sae Ishimaru, Daisuke Tomizawa, MD PhD, Daisuke Hasegawa, MD PhD, Takeshi Inukai, MD PhD, Yuki Arakawa, Takahiro Aoki, MD, Mayuko Okuya, Kiyohiko Kaizu, Keisuke Kato, MD, Yuichi Taneyama, Katsuyoshi Koh, MD PhD, Masahiro Tsuchida, MD PhD, Akira Ohara, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2262.
https://doi.org/10.1182/blood.V124.21.2262.2262
Published: 2014
Journal Articles

Central Morphology Review of Childhood Bone Marrow Failure in Japan

Asahito Hama, MD PhD, Manabe Atsushi, MD PhD, Daisuke Hasegawa, MD PhD, Kazue Nozawa, Yusuke Okuno, MD PhD, Masahiro Irie, MD PhD, Hideki Muramatsu, MD PhD, Yoshiyuki Takahashi, MD PhD, Kenichiro Watanabe, MD PhD, Akira Ohara, MD PhD, Masafumi Ito, MD PhD, Seiji Kojima, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1604.
https://doi.org/10.1182/blood.V124.21.1604.1604
Published: 2014
Journal Articles

Genetic Basis of Myeloid Proliferation Related to Down Syndrome

Kenichi Yoshida, MD, Tsutomu Toki, PhD, Myoung-ja Park, MD, PhD, Yusuke Okuno, MD, PhD, Yuichi Shiraishi, PhD, Masashi Sanada, MD, Ayana Kon, MD, Yasunobu Nagata, MD, Aiko Sato-Otsubo, PhD, Yusuke Sato, MD, RuNan Wang, MD, Kiminori Terui, MD, PhD, Rika Kanezaki, MS, Norio Shiba, MD, Kenichi Chiba, BA, Hiroko Tanaka, BA, Asahito Hama, MD, PhD, Daisuke Hasegawa, MD, PhD, Kazuhiro Nakamura, MD, PhD, Hirokazu Kanegane, MD, PhD, Keiko Tsukamoto, MD, PhD, Souichi Adachi, MD, PhD, Satoru Miyano, PhD, Seiji Kojima, Shai Izraeli, MD, Yasuhide Hayashi, MD, PhD, Etsuro Ito, Seishi Ogawa, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 535.
https://doi.org/10.1182/blood.V120.21.535.535
Published: 2012
Journal Articles

Low-Dose Cytosine Arabinoside Therapy for Neonates with Down Syndrome (DS) and Transient Leukemia (TL).

Hideki Muramatsu, MD, PhD, Yasuhide Hayashi, MD, PhD, Machiko Kawamura, MD, PhD, Seiji Kojima, MD, PhD, Miharu Yabe, Keiichi Isoyama, Tomohiko Taki, MD, PhD, Kohichiro Tsuji, MD, PhD, Masahiro Tsuchida, MD, PhD, Atsushi Manabe, Etsuro Ito, MD, PhD, Shotaro Iwamoto, MD, PhD, Hiromi Kato, Aiko Sumie, Takashi Taga, MD, PhD, Keiko Nomura, Daisuke Hasegawa, MD, PhD, Ken-ichiro Watanabe, Akira Kikuchi
Journal: Blood
Blood (2010) 116 (21): 1074.
https://doi.org/10.1182/blood.V116.21.1074.1074
Published: 2010