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Journal Articles

Trials in Progress: A Phase I Study to Evaluate the Safety and Pharmacokinetic Profiles of CB-5339 in Participants with Relapsed/Refractory Acute Myeloid Leukemia or Relapsed/Refractory Intermediate or High-Risk Myelodysplastic Syndrome

Lina Benajiba, MD PhD, Hetty E. Carraway, MD MBA, Nada Hamad, MB.BS, FRACP, FRCPA, Eytan M. Stein, MD, Costas K. Yannakou, MBBS (Hons), FRACP, FRCPA, Amy Burroughs, Scott Harris, Hayley Lane, Dorothy D. Nguyen, MD, Monic Stuart, MD MPH, Jesse Vargas, PhD, Alexandre Puissant, PhD, Kimberly Stegmaier, MD, Courtney D. DiNardo, MD MSCE

Blood (2020) 136 (Supplement 1): 21.

https://doi.org/10.1182/blood-2020-140636

Published: 2020

Journal Articles

Microrna-31 Regulates T-Cell Metabolism Via HIF1α and Promotes Effector Function

Yongxia Wu, PhD MD, Mengmeng Zhang, MD, David Bastian, Mohammed Hanief Sofi, PhD MS, Steven Douglas Schutt, BS, Hee-Jin Choi, PhD, Corey Mealer, Hung D Nguyen, PhD, Linlu Tian, Xue-Zhong Yu, MD MS

Blood (2019) 134 (Supplement_1): 623.

https://doi.org/10.1182/blood-2019-131587

Published: 2019

Journal Articles

Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice

Anusara Daenthanasanmak, Supinya Iamsawat, Paramita Chakraborty, Hung D. Nguyen, David Bastian, Chen Liu, Shikhar Mehrotra, Xue-Zhong Yu

Blood (2019) 133 (3): 266–279.

https://doi.org/10.1182/blood-2018-07-863233

Published: 2019

Includes: Supplemental data

Journal Articles

Association of Donor T Cell Repertoire in Host Lymphoid and Target Organs and Gvhd Development

Yongxia Wu, PhD MD, Jianing Fu, PhD, Anusara Daenthanasanmak, PhD, Hung D Nguyen, PhD, Mohammed Hanief Sofi, PhD MS, Jessica Lauren Heinrichs, BS, MS, Yuejun Liu, PhD, Steven Douglas Schutt, BS, David Bastian, Xue-Zhong Yu, MD MS

Blood (2018) 132 (Supplement 1): 4525.

https://doi.org/10.1182/blood-2018-99-119956

Published: 2018

Journal Articles

Adoptive Therapy with Cord Blood Regulatory T Cells Does Not Impair Anti-Leukemia Activity of Infused Donor Cells

Hongbing Ma, MD, Mitsutaka Nishimoto, MD PhD, Ke Zeng, PhD, Tuongvan D Nguyen, William Schuler, Joshua Kellner, Jaimol Peedikayil, PhD, Mi-Ae Lyu, Santhana Thangavelu-Devaraj, Simrit Parmar, MBBS

Blood (2018) 132 (Supplement 1): 5214.

https://doi.org/10.1182/blood-2018-99-119239

Published: 2018

Journal Articles

Complement Promotes Gvhd through Suppressing Autophagy in Recipient Dendritic Cells after Allogeneic Hematopoietic Cell Transplantation in Mice

Hung D Nguyen, PhD, David Bastian, Sandeepkumar Kuril, MD, Mohammmed Dany, David Fairlie, PhD, Carl Atkinson, PhD, Besim Ogretmen, PhD, Stephen Tomlinson, PhD, Xue-Zhong Yu, MD MS

Blood (2017) 130 (Supplement 1): 1904.

https://doi.org/10.1182/blood.V130.Suppl_1.1904.1904

Published: 2017

Journal Articles

Inhibition of Sirt-1 Alleviates Acute and Chronic Graft-Versus-Host-Disease While Preserving Graft-Versus-Leukemia Effect

Anusara Daenthanasanmak, Supinya Iamsawat, MSc, Hung D Nguyen, PhD, Shikhar Mehrotra, PhD, Xue-Zhong Yu, MD MS

Blood (2017) 130 (Supplement 1): 208.

https://doi.org/10.1182/blood.V130.Suppl_1.208.208

Published: 2017

Journal Articles

NKG2D Negatively Regulates CD4 T Cells in Allo-Response in Mice

Mengmeng Zhang, MD, Yongxia Wu, PhD MD, David Bastian, Hung D Nguyen, PhD, Supinya Iamsawat, MSc, Anusara Daenthanasanmak, Fangping Chen, MD PhD, Xue-Zhong Yu, MD MS

Blood (2017) 130 (Supplement 1): 2279.

https://doi.org/10.1182/blood.V130.Suppl_1.2279.2279

Published: 2017

Journal Articles

U Distinct Roles of IL-12Rβ1 and IL-23R in the Development of Acute and Chronic Gvhd

David Bastian, Hung D Nguyen, PhD, Yongxia Wu, PhD MD, Steven Douglas Schutt, BS, Anusara Daenthanasanmak, Mohammed Hanief Sofi, PhD MS, Supinya Iamsuwat, Mengmeng Zhang, MD, Xue-Zhong Yu, MD MS

Blood (2017) 130 (Supplement 1): 1005.

https://doi.org/10.1182/blood.V130.Suppl_1.1005.1005

Published: 2017

Journal Articles

Oxidative Stress Regulates T Cell Pathogenicity in Gvhd

Mohammed Hanief Sofi, PhD MS, Yongxia Wu, PhD MD, Min Dai, MD, Steven Douglas Schutt, BS, Anusara Daenthanasanmak, Jessica Lauren Heinrichs, BS, MS, Hung D Nguyen, PhD, David Bastian, Supinya Iamsawat, MSc, Mengmeng Zhang, MD, Shikhar Mehrotra, PhD, Xue-Zhong Yu, MD MS

Blood (2017) 130 (Supplement 1): 3168.

https://doi.org/10.1182/blood.V130.Suppl_1.3168.3168

Published: 2017

Journal Articles

Targeting JAK2 Kinase Promotes Foxp3 Stability and Function of CD8iTregs in Prevention of Graft-Versus-Host Disease

Supinya Iamsawat, Anusara Daenthanasanmak, Jessica H. Voss, PhD, Hung D Nguyen, PhD, Xue-Zhong Yu, MD MS

Blood (2017) 130 (Supplement 1): 165.

https://doi.org/10.1182/blood.V130.Suppl_1.165.165

Published: 2017

Journal Articles

Lysosomal Acid Lipase Is a Potential Therapeutic Target for Controlling Gvhd after Allogeneic Hematopoietic Cell Transplantation in Mice

Sandeepkumar Kuril, MD, Hung D Nguyen, PhD, Hong Du, MD, Cong Yan, MD, Xue-Zhong Yu, MD MS

Blood (2017) 130 (Supplement 1): 206.

https://doi.org/10.1182/blood.V130.Suppl_1.206.206

Published: 2017

Journal Articles

MiR-17-92 Is Required for the Pathogenicity of T and B Cells in Chronic Gvhd

Yongxia Wu, PhD, Steven D Schutt, BS, Ryan P Flynn, PhD, Mengmeng Zhang, MD, Hung D Nguyen, PhD, Bruce R. Blazar, MD, Xue-Zhong Yu, PhD

Blood (2016) 128 (22): 4535.

https://doi.org/10.1182/blood.V128.22.4535.4535

Published: 2016

Journal Articles

Inhibition of Alternative Complement Pathway in Target Organs Represents a Novel and Effective Approach to Control Gvhd While Sparing GVL Effect

Hung D Nguyen, PhD, Ali Alawieh, MD PhDCandidate, David A Bastian, BS, Anusara Daenthanasanmak, PhD, Steven D Schutt, BS, Supinya Iamsawat, MSc, Yongxia Wu, PhD, Atkinson Carl, PhD, Stephen Tomlinson, PhD, Xue-Zhong Yu, PhD

Blood (2016) 128 (22): 807.

https://doi.org/10.1182/blood.V128.22.807.807

Published: 2016

Journal Articles

Enhance T Cell Immunotherapy By Targeting PIM-2 Kinase

Anusara Daenthanasanmak, PhD, Yongxia Wu, PhD, Supinya Iamsawat, MSc, Hung D Nguyen, PhD, Shikhar Mehrotra, PhD, Andrew Kraft, MD, Xue-Zhong Yu, PhD

Blood (2016) 128 (22): 815.

https://doi.org/10.1182/blood.V128.22.815.815

Published: 2016

Journal Articles

Serum amyloid A overrides T reg anergy via monocyte-dependent and T reg -intrinsic, SOCS3-associated pathways

Khoa D. Nguyen, Claudia Macaubas, Kari C. Nadeau, Phi Truong, Taejin Yoon, Tzielan Lee, Jane L. Park, Elizabeth D. Mellins

Blood (2011) 117 (14): 3793–3798.

https://doi.org/10.1182/blood-2010-11-318832

Published: 2011

Includes: Supplemental data

Journal Articles

EBV-Specific Cytotoxic T Lymphocytes by LMP2a- and EBNA3a-Specific T Cell Receptor Gene Transfer for Adoptive Therapy in EBV-Associated Hodgkin’s Disease and Post-Transplant Lymphoma.

Tuan D. Nguyen, Haike Gelfort, PhD, Kathrin Sebelin-Wulf, Oliver Schmetzer, PhD, Wolfgang Uckert, PhD, Antonio Pezzutto, MD, Marion Subklewe, MD

Blood (2007) 110 (11): 2334.

https://doi.org/10.1182/blood.V110.11.2334.2334

Published: 2007

Journal Articles

A Novel Role of Histone Deacetylase 11 (HDAC11) in the Regulation of IL-10 Production and Immune Tolerance Mediated by Antigen-Presenting Cells.

Hongwei Wang, MD, Fengdong Cheng, M.D, D. Nguyen, M.D, I. Suarez, Phd, K. Wright, Phd, A.P. Atadja, Phd, E. Seto, Phd, K. Bhalla, M.D, A. Villagra, Phd, E.M. Sotomayor, M.D

Blood (2007) 110 (11): 1330.

https://doi.org/10.1182/blood.V110.11.1330.1330

Published: 2007

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Trials in Progress: A Phase I Study to Evaluate the Safety and Pharmacokinetic Profiles of CB-5339 in Participants with Relapsed/Refractory Acute Myeloid Leukemia or Relapsed/Refractory Intermediate or High-Risk Myelodysplastic Syndrome

Microrna-31 Regulates T-Cell Metabolism Via HIF1α and Promotes Effector Function

Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice

Association of Donor T Cell Repertoire in Host Lymphoid and Target Organs and Gvhd Development

Adoptive Therapy with Cord Blood Regulatory T Cells Does Not Impair Anti-Leukemia Activity of Infused Donor Cells

Complement Promotes Gvhd through Suppressing Autophagy in Recipient Dendritic Cells after Allogeneic Hematopoietic Cell Transplantation in Mice

Inhibition of Sirt-1 Alleviates Acute and Chronic Graft-Versus-Host-Disease While Preserving Graft-Versus-Leukemia Effect

NKG2D Negatively Regulates CD4 T Cells in Allo-Response in Mice

U Distinct Roles of IL-12Rβ1 and IL-23R in the Development of Acute and Chronic Gvhd

Oxidative Stress Regulates T Cell Pathogenicity in Gvhd

Targeting JAK2 Kinase Promotes Foxp3 Stability and Function of CD8iTregs in Prevention of Graft-Versus-Host Disease

Lysosomal Acid Lipase Is a Potential Therapeutic Target for Controlling Gvhd after Allogeneic Hematopoietic Cell Transplantation in Mice

MiR-17-92 Is Required for the Pathogenicity of T and B Cells in Chronic Gvhd

Inhibition of Alternative Complement Pathway in Target Organs Represents a Novel and Effective Approach to Control Gvhd While Sparing GVL Effect

Enhance T Cell Immunotherapy By Targeting PIM-2 Kinase

Serum amyloid A overrides T reg anergy via monocyte-dependent and T reg -intrinsic, SOCS3-associated pathways

EBV-Specific Cytotoxic T Lymphocytes by LMP2a- and EBNA3a-Specific T Cell Receptor Gene Transfer for Adoptive Therapy in EBV-Associated Hodgkin’s Disease and Post-Transplant Lymphoma.

A Novel Role of Histone Deacetylase 11 (HDAC11) in the Regulation of IL-10 Production and Immune Tolerance Mediated by Antigen-Presenting Cells.

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