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Christian Brendel, PhD
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Journal Articles

Distinct Genetic Pathways Define Leukemia Predisposition Versus Adaptive Clonal Hematopoiesis in Shwachman-Diamond Syndrome

Alyssa L. Kennedy, MDPhD, Kasiani C. Myers, MD, James Bowman, PhD, Christopher J. Gibson, MD, Gwen M. Muscato, Robert Klein, Kaitlyn Ballotti, Nicholas Camarda, Elissa M. Furutani, MD, Chad E. Harris, MS, Shanshan Liu, PhD, Ashley Galvin, Maggie Malsch, MSN, RN, David C. Dale, MD, John M Gansner, MD PhD, Taizo A. Nakano, MD, Alison A. Bertuch, MD, Adrianna Vlachos, MD, Jeff H. Lipton, MD PhD, Paul Castillo, MD, James Connelly, John Edwards, MD, Nobuko Hijiya, MD, Richard Ho, MD, Inga Hofmann, MD, James N Huang, MD, Sioban B. Keel, MD, Adam J. Lamble, MD, Bonnie W Lau, MD PhD, Kelly J. Walkovich, MD, Maxim Norkin, MD, Wendy Stock, MD, Steffen Boettcher, Christian Brendel, PhD, Elliot Stieglitz, MD, Mark D. Fleming, MD DPhil, Stella M. Davies, PhD MBBS, MRCP, Edie A. Weller, Chris Bahl, PhD, Scott L. Carter, PhD, Akiko Shimamura, MD PhD, R. Coleman Lindsley, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 35–36.
https://doi.org/10.1182/blood-2020-137125
Published: 2020
Journal Articles

Interleukin-10 Signaling in Hematopoietic Stem and Progenitor Cells Maintains Stem Cell Function and Regulates Inflammation-Induced Myeloid Cell Output

Amanda McCabe, PhD, Christian Brendel, PhD, Sandra Frei, PhD, Denise Klatt, MSc, Martin Bentler, Scott Snapper, MD PhD, David A. Williams, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2407.
https://doi.org/10.1182/blood-2018-99-116168
Published: 2018
Journal Articles

Highly Efficient Therapeutic Gene Editing of BCL11A enhancer in Human Hematopoietic Stem Cells from ß-Hemoglobinopathy Patients for Fetal Hemoglobin Induction

Jing Zeng, MD, Daniel E. Bauer, MD PhD, Yuxuan Wu, PhD, Benjamin P Roscoe, Pengpeng Liu, Qiuming Yao, PhD, Cicera Lazzarrotto, M. Kendell Clement, Mitchel A. Cole, BS, Kevin Luk, Cristina Baricordi, Erica B. Esrick, MD, John P Manis, MD, David Dorfma, David A. Williams, MD, Alessandra Biffi, MD PhD, Carlo Brugnara, MD, Luca Biasco, Christian Brendel, PhD, Luca Pinello, PhD, Shengdar Tsai, PhD, Scot A. Wolfe
Journal: Blood
Blood (2018) 132 (Supplement 1): 3482.
https://doi.org/10.1182/blood-2018-99-119365
Published: 2018
Journal Articles

Flipping the Switch: Initial Results of Genetic Targeting of the Fetal to Adult Globin Switch in Sickle Cell Patients

Erica B. Esrick, MD, Christian Brendel, PhD, John P Manis, MD, Myriam A Armant, PhD, Helene Negre, PhD, Colleen Dansereau, MSN, RN, CPN, Marioara Felicia Ciuculescu, MD, Stephanie Patriarca, Brenda Mackinnon, BSN, RN, Heather Daley, BS, Shanna Richard, Daniela Abriss, Renee Maxwell, Stephen Braunewell, BS, Lauryn Christiansen, BS, Sarah Nikiforow, MD PhD, Jerome Ritz, MD PhD, Maureen Achebe, MD, Olivier Negre, PhD, Leslie E. Lehmann, MD, Matthew M Heeney, MD, Alessandra Biffi, MD PhD, David A. Williams, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1023.
https://doi.org/10.1182/blood-2018-99-116733
Published: 2018
Journal Articles

Deletion of Murine Rhoh induces More Aggressive Diffuse Large B Cell Lymphoma (DLBCL) Via Interaction with Kaiso and Regulation of BCL-6 Expression

Hiroto Horiguchi, MDPhD, Marioara Felicia Ciuculescu, MD, Anja Troeger, MD, Haiming Xu, PhD, Christian Brendel, PhD, David A. Williams, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1574.
https://doi.org/10.1182/blood-2018-99-115238
Published: 2018
Journal Articles

Deletion of Rhoh Accelerates Development of Diffuse Large B Cell Lymphoma in Bcl-6 Transgenic Mouse Model

Hiroto Horiguchi, MDPhD, Marioara Felicia Ciuculescu, MD, Christian Brendel, PhD, David A. Williams, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1470.
https://doi.org/10.1182/blood.V130.Suppl_1.1470.1470
Published: 2017
Journal Articles

Preclinical Evaluation of a Novel Lentiviral Vector Driving Lineage-Specific BCL11A Knockdown, β-Globin Induction and Simultaneous Repression of β-Globin for the Potential Treatment of Sickle Cell Disease

Olivier Negre, PhD, Christian Brendel, PhD, Geoffrey B. Parsons, Min Luo, PhD, Myriam A Armant, PhD, Swaroopa Guda, PhD, Lauryn Christiansen, Gretchen Lewis, BMBS, Gabor Veres, PhD, Melissa Bonner, PhD, David A. Williams, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3557.
https://doi.org/10.1182/blood.V130.Suppl_1.3557.3557
Published: 2017
Journal Articles

Optimization of Bcl11a Knockdown By miRNA Scaffold Embedded Shrnas Leading to Enhanced Induction of Fetal Hemoglobin in Erythroid Cells for the Treatment of Beta-Hemoglobinopathies

Christian Brendel, PhD, Swaroopa Guda, PhD, Raffaele Renella, MD PhD, Peng Du, PhD, Daniel E. Bauer, MD, PhD, Matthew C. Canver, BS, Sophia C. Kamran, MD, James Thornton, PhD, Helen de Boer, BAS, Michael D. Milsom, PhD, Stuart H. Orkin, MD, Richard Gregory, PhD, David A. Williams, MD
Journal: Blood
Blood (2014) 124 (21): 2150.
https://doi.org/10.1182/blood.V124.21.2150.2150
Published: 2014
Journal Articles

Improving Hematopoietic Stem Cell Based Gene Therapy By Targeting CD133+ Cells

Benjamin Goebel, MD, Christian Brendel, PhD, Daniela Abriss, Sabrina Kneissl, PhD, Martijn Brugman, PhD, Christian J. Buchholz, PhD, Hubert Serve, MD, Manuel Grez, PhD
Journal: Blood
Blood (2013) 122 (21): 4202.
https://doi.org/10.1182/blood.V122.21.4202.4202
Published: 2013