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Journal Articles

Genome-Wide CRISPR/Cas9 Screen Identifies AraC-Daunorubicin-Etoposide (ADE) Response Modulators Associated with Clinical Outcomes in Pediatric AML

Free
Nam H.K. Nguyen, Abderrahmane Tagmount, Jeffrey E. Rubnitz, Raul C. Ribeiro, Xueyuan Cao, Stanley B. Pounds, Chris D. Vulpe, Jatinder K. Lamba
Journal: Blood
Blood (2022) 140 (Supplement 1): 5947–5948.
https://doi.org/10.1182/blood-2022-159322
Published: 2022
Journal Articles

Nelfinavir Overcomes Proteasome Inhibitor Resistance in Multiple Myeloma By Modulating Membrane Lipid Bilayer Composition and Fluidity

Free
Andrej Besse, Lenka Besse, Sara C. Stolze, Amin Sobh, PhD, Esther A. Zaal, Alwin J van der Ham, Mario Ruiz, Santosh Phuyal, Lorina Büchler, Marc Sathianathan, Bogdan I. Florea, Jan Borén, Marcus Ståhlman, Alex Loguinov, Bart Everts, Celia R. Berkers, Marc Pilon, Hesso Farhan, Chris D. Vulpe, Herman S. Overkleeft, Christoph Driessen, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11.
https://doi.org/10.1182/blood-2020-136253
Published: 2020
Journal Articles

CRISPR Dropout Screens Identify DHODH, PIK3C3 , and Crkl as Potential Therapeutic Targets in Acute Myeloid Leukemia

Free
Gregory Takacs, BS, Yujia Zhou, BS,BA, David J. King, BS, Amy Meacham, MS, Loguinov Alex, PhD, Abderrahmane Tagmount, PhD, Amin Sobh, PhD, Max Russo, BS, Chris D Vulpe, MD PhD, Christopher R. Cogle, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1452.
https://doi.org/10.1182/blood-2019-128180
Published: 2019
Journal Articles

Genome-Scale CRISPR-Cas9 Synthetic Lethal Screening of AML Cell Line Identified Functional Modulators of Etoposide Resistance Predictive of Clinical Outcome in AML Patients

Free
Roya Rafiee, M.Sc., PhD, Amin Sobh, PhD, Abdelrahman H. Elsayed, MSc, Abderrahmane Tagmount, PhD, Chris D Vulpe, MD PhD, Jatinder K Lamba, M.Sc., PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2685.
https://doi.org/10.1182/blood-2019-131312
Published: 2019
Journal Articles

Genome-Wide CRISPR/Cas9-Mediated Loss-of-Function Screening in Human Erythroleukemic Cells Identifies Novel Cellular Components Involved in Iron and Heme Trafficking

Free
Amin Sobh, Alex Loguinov, PhD, Paula Fraenkel, MD, Chris D Vulpe, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 169.
https://doi.org/10.1182/blood.V130.Suppl_1.169.169
Published: 2017
Journal Articles

Nicotinamide N-Methyltransferase Expression Decreases in Iron Overload Exacerbating Iron-Induced Hepatotoxicity

Free
Tiago De Bone Koppe, MSc, Bonnie Patchen, BS, Aaron Cheng, BA, Manoj Bhasin, PhD, Chris D. Vulpe, MD, Jose M. Fernandez-Real, MD PhD, Robert K. Schwartz, MD PhD, Pavlos Pissios, PhD, Paula G. Fraenkel, MD
Journal: Blood
Blood (2016) 128 (22): 204.
https://doi.org/10.1182/blood.V128.22.204.204
Published: 2016
Journal Articles

Association of Helicobacter Pylori Infection with Iron Deficiency in Asians and Pacific Islanders but not in Caucasians, African Americans, or Hispanics

Free
Gordon D. McLaren, MD, Joseph A. Murray, MD, Stela McLachlan, PhD, Paul C. Adams, MD, John H. Eckfeldt, MD, Chris D. Vulpe, MD, Victor R. Gordeuk, MD, Tricia Brantner, Catherine Leiendecker-Foster, M.S., CLSp(MB), Wen-Pin Chen, MS, Anthony A. Killeen, MD, Ronald T. Acton, PhD, Lisa F. Barcellos, PhD, Deborah A. Nickerson, PhD, Kenneth B. Beckman, PhD, Christine E. McLaren, PhD
Journal: Blood
Blood (2015) 126 (23): 4556.
https://doi.org/10.1182/blood.V126.23.4556.4556
Published: 2015
Journal Articles

Identification of Differentially Expressed Genes in Mice with Nutritional or Genetic Causes of Iron Overload

Free
Aaron Cheng, Luke Schissler, Bonnie Patchen, Vera Gaun, Manoj Bhasin, PhD, Chris D. Vulpe, MD PhD, Paula G. Fraenkel, MD
Journal: Blood
Blood (2014) 124 (21): 2681.
https://doi.org/10.1182/blood.V124.21.2681.2681
Published: 2014
Journal Articles

Celiac Disease: Association with Iron Deficiency in Caucasians but Not in Non-Caucasians.

Free
Joseph A. Murray, MD, Stela McLachlan, PhD, Paul C. Adams, MD, John H. Eckfeldt, MD, PhD, Chad P. Garner, PhD, Chris D. Vulpe, MD, PhD, Victor R. Gordeuk, MD, Tricia L. Brantner, Catherine Leiendecker-Foster, MS, CLSp(MB), Anthony A. Killeen, MD, Ronald T. Acton, PhD, Lisa F. Barcellos, PhD, Kenneth B. Beckman, PhD, Gordon D. McLaren, MD, Christine E. McLaren, PhD
Journal: Blood
Blood (2012) 120 (21): 2095.
https://doi.org/10.1182/blood.V120.21.2095.2095
Published: 2012
Journal Articles

Associations Between Single Nucleotide Polymorphisms in Iron-Related Genes and Iron Status in Multiethnic Populations

Free
Christine E. McLaren, PhD, Stela McLachlan, PhD, Chad P. Garner, PhD, Chris D. Vulpe, MD, PhD, Victor R. Gordeuk, MD, John H. Eckfeldt, MD, PhD, Paul C. Adams, MD, Ronald T. Acton, PhD, Joseph A. Murray, MD, Catherine Leiendecker-Foster, MS, CLSp(MB), Beverly M. Snively, PhD, Lisa F. Barcellos, PhD, James D. Cook, MD, Gordon D. McLaren, MD
Journal: Blood
Blood (2011) 118 (21): 2105.
https://doi.org/10.1182/blood.V118.21.2105.2105
Published: 2011
Journal Articles

Lack of Association between Single Nucleotide Polymorphism rs3811647 in the TF Gene and Iron Status in Patients with Iron Deficiency and Control Subjects

Free
Gordon D. McLaren, MD, Catherine A. McCarty, PhD, MPH, Marylyn Ritchie, PhD, Stephen Turner, MS, Victor R. Gordeuk, MD, Chad P. Garner, PhD, Chris D. Vulpe, MD, PhD, Stela McLachlan, PhD, Paul C. Adams, MD, Christine E. McLaren, PhD
Journal: Blood
Blood (2010) 116 (21): 4257.
https://doi.org/10.1182/blood.V116.21.4257.4257
Published: 2010
Journal Articles

Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice

Free
Huijun Chen, Zouhair K. Attieh, Trent Su, Basharut A. Syed, Hua Gao, Rima M. Alaeddine, Tama C. Fox, Julnar Usta, Claire E. Naylor, Robert. W. Evans, Andrew T. McKie, Gregory J. Anderson, Chris D. Vulpe
Journal: Blood
Blood (2004) 103 (10): 3933–3939.
https://doi.org/10.1182/blood-2003-09-3139
Published: 2004
Journal Articles

Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency

Free
Huijun Chen, Trent Su, Zouhair K. Attieh, Tama C. Fox, Andrew T. McKie, Gregory J. Anderson, Chris D. Vulpe
Journal: Blood
Blood (2003) 102 (5): 1893–1899.
https://doi.org/10.1182/blood-2003-02-0347
Published: 2003