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Journal Articles

Concomitant Targeting of FLT3 and BTK with CG'806 Overcomes FLT3-Inhibitor Resistance through Inhibition of Autophagy

Weiguo Zhang, MD PhD, Guopan Yu, MD, PhD, Hongying Zhang, MD, PhD, Charlie Ly, BS, Bin Yuan, Vivian Ruvolo, MS, Sujan Piya, PhD, Seemana Bhattacharya, PhD, Qi Zhang, PhD, Gautam Borthakur, MD, Venkata Lokesh Battula, PhD, Marina Y. Konopleva, MD PhD, William G Rice, PhD, Michael Andreeff, MD PhD

Blood (2018) 132 (Supplement 1): 2635.

https://doi.org/10.1182/blood-2018-99-116643

Published: 2018

Journal Articles

The Pan-FLT3/BTK Multi-Kinase Inhibitor CG '806 Induces AML Killing in FLT-Mutant and Wild Type Cells, and Exerts Synergistic Pro-Apoptotic Effects with Concomitant Targeting of Anti-Apoptotic Bcl-2 and/or Mcl-1

Charlie Ly, BS, Weiguo Zhang, MD PhD, Guopan Yu, MD, PhD, Hong Mu, MD PhD, Hongying Zhang, MD, William Rice, PhD, Michael Andreeff, MD PhD

Blood (2017) 130 (Supplement 1): 3348.

https://doi.org/10.1182/blood.V130.Suppl_1.3348.3348

Published: 2017

Journal Articles

CG '806, a Novel Pan-FLT3/BTK Multi-Kinase Inhibitor, Induces Cell Cycle Arrest, Apoptosis or Autophagy in AML Cells Depending on FLT3 Mutation Status

Guopan Yu, MD, PhD, Weiguo Zhang, MD PhD, Charlie Ly, BS, Hongying Zhang, MD, William Rice, PhD, Michael Andreeff, MD PhD

Blood (2017) 130 (Supplement 1): 4629.

https://doi.org/10.1182/blood.V130.Suppl_1.4629.4629

Published: 2017

Journal Articles

Up-Regulation of iNOS in AML Blasts Creates an Immunosuppressive Microenvironment, Inhibits T-Cell Proliferation and Transforms T-Cells Towards a Tumor-Tolerating Phenotype

Rodrigo Jacamo, PhD, Nguyet-Minh Hoang, B.A., Ahmed Al Rawi, Charlie Ly, BS, Robin Parihar, MDPhD, Teresa McQueen, MS, Peter P. Ruvolo, PhD, Patrick Williams, MD PhD, Gheath Alatrash, DO, PhD, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD

Blood (2017) 130 (Supplement 1): 2443.

https://doi.org/10.1182/blood.V130.Suppl_1.2443.2443

Published: 2017

Journal Articles

Dual E-Selectin/CXCR4 Antagonist GMI-1359 Exerts Efficient Anti-Leukemia Effects in a FLT3 ITD Mutated Acute Myeloid Leukemia Patient-Derived Xenograft Murine Model

Weiguo Zhang, MD, PhD, Charlie Ly, Qi Zhang, MDPhD, Hong Mu, MD PhD, Venkata Lokesh Battula, PhD, Nalini Patel, Wendy Schober, Xin Han, MD MS, William E. Fogler, PhD, John L Magnani, PhD, Michael Andreeff, MD PhD

Blood (2016) 128 (22): 3519.

https://doi.org/10.1182/blood.V128.22.3519.3519

Published: 2016

Journal Articles

Mechanism-Based Combinatorial Strategy for Overcoming FLT3-Inhibitor Resistance in Dual FLT3 ITD and TKD Point Mutations

Charlie Ly, Weiguo Zhang, MD, PhD, Vivian Ruvolo, MS, Neil P. Shah, MD PhD, Michael Andreeff, MD PhD

Blood (2016) 128 (22): 2328.

https://doi.org/10.1182/blood.V128.22.2328.2328

Published: 2016

Journal Articles

AMG925, a Dual FLT3-CDK4/6 Inhibitor, Disrupts Survival Signaling and Triggers Apoptosis in AML Progenitor/Stem Cells

Zhihong Zeng, MD, Charlie Ly, Duncan Mak, BSc, MPhil, Neil P. Shah, MD PhD, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD

Blood (2016) 128 (22): 3938.

https://doi.org/10.1182/blood.V128.22.3938.3938

Published: 2016

NARROW

Concomitant Targeting of FLT3 and BTK with CG'806 Overcomes FLT3-Inhibitor Resistance through Inhibition of Autophagy

The Pan-FLT3/BTK Multi-Kinase Inhibitor CG '806 Induces AML Killing in FLT-Mutant and Wild Type Cells, and Exerts Synergistic Pro-Apoptotic Effects with Concomitant Targeting of Anti-Apoptotic Bcl-2 and/or Mcl-1

CG '806, a Novel Pan-FLT3/BTK Multi-Kinase Inhibitor, Induces Cell Cycle Arrest, Apoptosis or Autophagy in AML Cells Depending on FLT3 Mutation Status

Up-Regulation of iNOS in AML Blasts Creates an Immunosuppressive Microenvironment, Inhibits T-Cell Proliferation and Transforms T-Cells Towards a Tumor-Tolerating Phenotype

Dual E-Selectin/CXCR4 Antagonist GMI-1359 Exerts Efficient Anti-Leukemia Effects in a FLT3 ITD Mutated Acute Myeloid Leukemia Patient-Derived Xenograft Murine Model

Mechanism-Based Combinatorial Strategy for Overcoming FLT3-Inhibitor Resistance in Dual FLT3 ITD and TKD Point Mutations

AMG925, a Dual FLT3-CDK4/6 Inhibitor, Disrupts Survival Signaling and Triggers Apoptosis in AML Progenitor/Stem Cells

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ASH Publications

American Society of Hematology

Concomitant Targeting of FLT3 and BTK with CG'806 Overcomes FLT3-Inhibitor Resistance through Inhibition of Autophagy

The Pan-FLT3/BTK Multi-Kinase Inhibitor CG '806 Induces AML Killing in FLT-Mutant and Wild Type Cells, and Exerts Synergistic Pro-Apoptotic Effects with Concomitant Targeting of Anti-Apoptotic Bcl-2 and/or Mcl-1

CG '806, a Novel Pan-FLT3/BTK Multi-Kinase Inhibitor, Induces Cell Cycle Arrest, Apoptosis or Autophagy in AML Cells Depending on FLT3 Mutation Status

Up-Regulation of iNOS in AML Blasts Creates an Immunosuppressive Microenvironment, Inhibits T-Cell Proliferation and Transforms T-Cells Towards a Tumor-Tolerating Phenotype

Dual E-Selectin/CXCR4 Antagonist GMI-1359 Exerts Efficient Anti-Leukemia Effects in a FLT3 ITD Mutated Acute Myeloid Leukemia Patient-Derived Xenograft Murine Model

Mechanism-Based Combinatorial Strategy for Overcoming FLT3-Inhibitor Resistance in Dual FLT3 ITD and TKD Point Mutations

AMG925, a Dual FLT3-CDK4/6 Inhibitor, Disrupts Survival Signaling and Triggers Apoptosis in AML Progenitor/Stem Cells

Email alerts

ASH Publications

American Society of Hematology

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