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Cecile Marie Krejsa
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Journal Articles

Pathway Analysis Provides Mechanistic Insights into Navtemadlin (KRT-232) Activity and Synergy with Decitabine in Acute Myeloid Leukemia Preclinical Models

Jin Wang, Venu Valmeekam, Kaijin Wu, Jiang F. Zhong, Andres Stucky, Xuelian (Lili) Chen, Alex Duong, Jude Canon, Cecile Marie Krejsa, Kevin R. Kelly
Journal: Blood
Blood (2021) 138 (Supplement 1): 2232.
https://doi.org/10.1182/blood-2021-145364
Published: 2021
Journal Articles

Navtemadlin (KRT-232), a Small Molecule MDM2 Inhibitor, Is More Effective Than Decitabine Against Myeloproliferative Neoplasm-Blast Phase in a Patient-Derived Xenograft Model

Xiaoli Wang, Cing Siang Hu, Virginia Gillespie, Cecile Marie Krejsa, Ronald Hoffman
Journal: Blood
Blood (2021) 138 (Supplement 1): 3591.
https://doi.org/10.1182/blood-2021-153071
Published: 2021
Journal Articles

Potential Disease-Modifying Activity of Navtemadlin (KRT-232), a First-in-Class MDM2 Inhibitor, Correlates with Clinical Benefits in Relapsed/Refractory Myelofibrosis (MF)

Pankit Vachani, Andrzej Lange, Regina Garcia Delgado, Haifa Kathrin Al-Ali, Jesus Maria Hernández-Rivas, Jean-Jacques Kiladjian, Alessandro Vannucchi, Andrew Charles Perkins, Venu Valmeekam, Cecile Marie Krejsa, Anne Uyei, Jesse McGreivy, Wayne P. Rothbaum, John Mascarenhas, Srdan Verstovsek
Journal: Blood
Blood (2021) 138 (Supplement 1): 3581.
https://doi.org/10.1182/blood-2021-147543
Published: 2021
Journal Articles

A Mechanistic Physiologically Based Pharmacokinetic (PBPK) Drug Interaction Model for the Mouse Double Minute 2 (MDM2) Inhibitor KRT-232

Ian E. Templeton, PhD, Terry Podoll, PhD, Cecile Marie Krejsa, PhD, J. Greg Slatter, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 9–10.
https://doi.org/10.1182/blood-2020-135987
Published: 2020
Journal Articles

Effect of Food on MDM2 Inhibitor KRT-232 Pharmacokinetics and Macrophage Inhibitory Cytokine-1 (MIC-1) Response in Healthy Volunteers

Shekman Wong, PhD, Cecile Marie Krejsa, PhD, Dana Lee, PharmD, Anna Harris, Emilie Simard, MSc, Xiaohui Wang, Igor Rubets, PhD, Martine Allard, PharmD, PhD, Terry Podoll, PhD, Terry O'Reilly, MD, J. Greg Slatter, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 7–8.
https://doi.org/10.1182/blood-2020-135985
Published: 2020