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Journal Articles

PI3K/AKT/mTOR Signaling Is a Significant Druggable Pathway In Infant Acute Lymphoblastic Leukemia (ALL)

Karen A. Urtishak, PhD, Wang Li-San, PhD, David T. Teachey, MD, Tasian K. Sarah, MD, Jeffrey S. Barrett, PhD, I-Ming L. Chen, Susan R. Atlas, PhD, Richard C. Harvey, PhD, Nyla A. Heerema, PhD, Andrew J. Carroll, PhD, Stephen P. Hunger, MD, Cheryl L. Willman, MD, Carolyn A. Felix, MD

Blood (2013) 122 (21): 1669.

https://doi.org/10.1182/blood.V122.21.1669.1669

Published: 2013

Journal Articles

Zebrafish Ortholog of Human DOT1L Regulates Primitive and Transient Definitive Hematopoiesis and Controls hoxa9 and meis1 Expression

Giulia Morello, BSc, Patrizia Porazzi, PhD, Enrico Moro, PhD, Francesco Argenton, PhD, Giuseppe Basso, MD, Carolyn A. Felix, MD, Giuseppe Germano, PhD

Blood (2012) 120 (21): 849.

https://doi.org/10.1182/blood.V120.21.849.849

Published: 2012

Journal Articles

Predicting Clinical Dose-Exposure and Exposure-Response Relationships of Pan-Antiapoptotic BCL-2 Family Inhibitor Obatoclax in MLL Rearranged Infant Leukemias From Preclinical Disease Models and Adult Experience

Jeffrey S Barrett, PhD, Alena Y. Zhang, PhD, Karen A. Urtishak, PhD, Gwenn Danet-Desnoyers, PhD, Andrew J. Carroll, PhD, Stephen P. Hunger, MD, Carolyn A. Felix, MD

Blood (2011) 118 (21): 2580.

https://doi.org/10.1182/blood.V118.21.2580.2580

Published: 2011

Journal Articles

Unique Familial MLL -rearranged Precursor B Cell Infant Acute Lymphoblastic Leukemia (ALL) in Non-Twin Siblings

Karen A. Urtishak, PhD, Blaine W. Robinson, PhD, Jaclyn A. Biegel, PhD, Kim E. Nichols, MD, Julie W. Stern, MD, Carolyn A. Felix, MD

Blood (2011) 118 (21): 2417.

https://doi.org/10.1182/blood.V118.21.2417.2417

Published: 2011

Journal Articles

Mechanisms in Leukemia-Associated Chromosomal Translocations: Novel, High-Throughput Sequencing Method to Detect Topoisomerase II (TOP2) Cleavage Complexes Genome-Wide with Exact Base Resolution,

Carolyn A. Felix, MD, Marie L. Carillo, MS, Karen A. Urtishak, PhD, Isabelle C. Dragomir, BS, Michele E. Paessler, DO, Andrew D. Bantly, BS, Marybeth Helfrich, BS, Li-San Wang, PhD, Brian D. Gregory, PhD

Blood (2011) 118 (21): 3445.

https://doi.org/10.1182/blood.V118.21.3445.3445

Published: 2011

Journal Articles

Infant Acute Lymphoblastic Leukemias Are Pan-Sensitive to Obatoclax Across molecular/Cytogenetic Subtypes, Especially MLL - ENL , and gene Expression Profiles Determine Obatoclax IC 50 : A Report on the Children's Oncology Group (COG) P9407 Trial

Blood (2010) 116 (21): 2757.

https://doi.org/10.1182/blood.V116.21.2757.2757

Published: 2010

Journal Articles

af9 Regulates gata2 Expression During Early Hemangioblast Specification and Vascular Pattern Formation In Zebrafish.

Giuseppe Germano, PhD, Ilaria Guariento, BSc, Natascia Tiso, PhD, Blaine W. Robinson, PhD, Enrico Moro, PhD, Francesco Argenton, PhD, Carolyn A. Felix, MD, Giuseppe Basso, MD

Blood (2010) 116 (21): 2600.

https://doi.org/10.1182/blood.V116.21.2600.2600

Published: 2010

Journal Articles

Gene Expression Profiling Reveals Genes Predictive of Outcome In Infant Acute Lymphoblastic Leukemia (ALL) and Distinctive Age-Related Gene Expression Profiles (< 90 Days vs. > 90 Days): A Children's Oncology Group Study

Blood (2010) 116 (21): 412.

https://doi.org/10.1182/blood.V116.21.412.412

Published: 2010

Journal Articles

Zebrafish Mll Depletion Model Phenocopies Mammalian Mll Depletion and Implicates MLL as Master Regulator of Novel Developmental Hematopoietic Targets.

Blaine W. Robinson, PhD, Yuanquan Song, PhD, Giuseppe Germano, PhD, Patricia Ernst, PhD, Joshua Abrams, Marion Scott, Amy Kugath, Marybeth Helfrich, J. Oriol Sunyer, PhD, Jennifer Rhodes, PhD, Rita Balice-Gordon, PhD, Carolyn A. Felix, MD

Blood (2009) 114 (22): 3655.

https://doi.org/10.1182/blood.V114.22.3655.3655

Published: 2009

Journal Articles

Specific MLL Partner Genes in Infant Acute Lymphoblastic Leukemia (ALL) Associated with Outcome Are Linked to Age and White Blood Cell Count (WBC) at Diagnosis: A Report On the Children's Oncology Group (COG) P9407 Trial.

Blaine W. Robinson, PhD, Meenakshi Devidas, PhD, Andrew J. Carroll, PhD, Richard C. Harvey, PhD, Nyla A. Heerema, PhD, Cheryl L. Willman, MD, Amanda R. Hudome, Elliot C. Woods, Nancy C. Ballantyne, Gregory H. Reaman, MD, Joanne M. Hilden, MD, Bruce M. Camitta, MD, Naomi J. Winick, MD, William L. Carroll, MD, Stephen P Hunger, MD, Zoann E. Dreyer, MD, Carolyn A. Felix, MD

Blood (2009) 114 (22): 907.

https://doi.org/10.1182/blood.V114.22.907.907

Published: 2009

Journal Articles

Age Is the Strongest Determinant of Leukemia Blast Cell Gene Expression in MLL -Rearranged Infant ALL and MLL-AF4 Directs a Distinct Gene Expression Profile Related to CNS Disease.

Blaine W. Robinson, PhD, Kajia Cao, PhD, Joanne M. Hilden, MD, Patricia A. Dinndorf, MD, Nyla A. Heerema, PhD, Harland N. Sather, Ron McGlennen, Stephen P. Hunger, MD, Gregory H. Reaman, MD, Li-San Wang, PhD, Carolyn A. Felix, MD

Blood (2008) 112 (11): 1200.

https://doi.org/10.1182/blood.V112.11.1200.1200

Published: 2008

Journal Articles

Pan-Anti-Apoptotic BCL-2 Family Inhibitor, Obatoclax, Activates Autophagic Cell Death Pathway and Has Potent Cytotoxicity in Infant and Pediatric MLL -Rearranged Leukemias

Alena Y. Zhang, PharmD, PhD, Blaine W. Robinson, PhD, Li-San Wang, PhD, Kajia Kao, PhD, Lori Cory, Jeffrey S. Barrett, PhD, Susan Atlas, PhD, I-Ming Chen, MS, Richard C. Harvey, PhD, Cheryl L. Willman, MD, Meenakshi Devidas, PhD, Andrew J. Carroll, PhD, Stephen P. Hunger, MD, Jonni S. Moore, PhD, Craig B. Thompson, MD, Mondira Kundu, MD, PhD, Carolyn A. Felix, MD

Blood (2008) 112 (11): 2647.

https://doi.org/10.1182/blood.V112.11.2647.2647

Published: 2008

Journal Articles

Cell Death Regulatory Gene Expression Correlates with MLL Rearrangement Status and Prognostic Clinical Covariates in Acute Leukemia in Infants.

Alena Y. Zhang, PharmD, PhD, Blaine W. Robinson, PhD, Kajia Kao, PhD, Kathryn Behling, MD, PhD, Meenakshi Devidas, PhD, Todd Alonzo, PhD, Susana C. Raimondi, PhD, Andrew Carroll, PhD, Robert J. Arceci, MD, PhD, Alan Gamis, MD, Stephen P. Hunger, MD, Gregory H. Reaman, MD, Richard C. Harvey, PhD, Cheryl L. Willman, MD, Li-San Wang, PhD, Carolyn A. Felix, MD

Blood (2008) 112 (11): 2255.

https://doi.org/10.1182/blood.V112.11.2255.2255

Published: 2008

Journal Articles

Cloning and Characterization of the Zebrafish mll Ortholog.

Blaine W. Robinson, PhD, Giuseppe Germano, PhD, Yuanquan Song, Rita J. Balice-Gordon, PhD, Carolyn A. Felix, MD

Blood (2007) 110 (11): 1249.

https://doi.org/10.1182/blood.V110.11.1249.1249

Published: 2007

Journal Articles

Congenital Amniotic Band Syndrome and MLL Rearranged Neonatal Leukemia in an Infant with Multiple Pre-Conception and In Utero Exposures.

Anna Sechser Perl, MD, Blaine W. Robinson, PhD, Jaclyn A. Biegel, PhD, Elaine H. Zackai, MD, Christos P. Kolaris, MD, Carolyn A. Felix, MD

Blood (2006) 108 (11): 4286.

https://doi.org/10.1182/blood.V108.11.4286.4286

Published: 2006

Journal Articles

DNA Topoisomerase II Poisons and the Etiology of Acute Leukemia in Infants.

Christos P. Kolaris, BS, Diana J. Slater, BS, Anna Sechser Perl, MD, Eric F. Rappaport, PhD, Neil Osheroff, PhD, Carolyn A. Felix, MD

Blood (2005) 106 (11): 2850.

https://doi.org/10.1182/blood.V106.11.2850.2850

Published: 2005

Journal Articles

Pre-Clinical In Vitro Evaluation of BCL-2 Antisense Compound Genasense TM (G3139; Genta, Inc.) as a Targeted Pro-Apoptotic Agent for Leukemias with t(4;11)(q21;q23) Translocations.

Blaine W. Robinson, PhD, Kathyrn C. Behling, MD, PhD, Jeffrey S. Barrett, PhD, Manish Gupta, PhD, Jessicca M. Rege, PhD, Jonni S. Moore, PhD, Andrew D. Bantly, Junhyong Kim, PhD, George Hii, Cheryl L. Willman, MD, Jeffrey Potter, Peter C. Adamson, MD, Carolyn A. Felix, MD

Blood (2005) 106 (11): 3360.

https://doi.org/10.1182/blood.V106.11.3360.3360

Published: 2005

Journal Articles

Pan-BCL-2 Family Small Molecule Inhibitor GX015-070 (GeminX, Inc.) Exhibits Single Agent Cytotoxicity, Is Synergistic with Select Anti-Leukemia Cytotoxic Agents, and Induces Apoptosis in Cell Lines with t(4;11)(q21;q23) Translocations.

Jessicca M. Rege, PhD, Blaine W. Robinson, PhD, Manish Gupta, PhD, Jeffrey S. Barrett, PhD, Peter C. Adamson, MD, Kathryn C. Behling, MD, PhD, Andrew D. Bantly, Jonni S. Moore, PhD, Carolyn A. Felix, MD

Blood (2005) 106 (11): 3368.

https://doi.org/10.1182/blood.V106.11.3368.3368

Published: 2005

Journal Articles

Philadelphia Chromosome (Ph’) Negative, MLL -Rearranged AML Arising in a Patient Treated with Imatinib for CML.

Anna Sechser Perl, MD, Alexander E. Perl, MD, Blaine W. Robinson, PhD, Adam Bagg, MD, David Porter, MD, Ewa Tomczak, Peter C. Nowell, MD, Martin Carroll, MD, Carolyn A. Felix, MD

Blood (2005) 106 (11): 4880.

https://doi.org/10.1182/blood.V106.11.4880.4880

Published: 2005

Journal Articles

Cryptic MLL , AF10 , ARMC3 Rearrangement in Secondary AML Creates ARMC3-MLL Fusion That Disrupts Gene Encoding Armadillo Repeats Similar to Major Cancer Genes.

Giuseppe Germano, PhD, Blaine W. Robinson, PhD, Carolyn A. Felix, MD

Blood (2005) 106 (11): 4345.

https://doi.org/10.1182/blood.V106.11.4345.4345

Published: 2005

NARROW

PI3K/AKT/mTOR Signaling Is a Significant Druggable Pathway In Infant Acute Lymphoblastic Leukemia (ALL)

Zebrafish Ortholog of Human DOT1L Regulates Primitive and Transient Definitive Hematopoiesis and Controls hoxa9 and meis1 Expression

Predicting Clinical Dose-Exposure and Exposure-Response Relationships of Pan-Antiapoptotic BCL-2 Family Inhibitor Obatoclax in MLL Rearranged Infant Leukemias From Preclinical Disease Models and Adult Experience

Unique Familial MLL -rearranged Precursor B Cell Infant Acute Lymphoblastic Leukemia (ALL) in Non-Twin Siblings

Mechanisms in Leukemia-Associated Chromosomal Translocations: Novel, High-Throughput Sequencing Method to Detect Topoisomerase II (TOP2) Cleavage Complexes Genome-Wide with Exact Base Resolution,

Infant Acute Lymphoblastic Leukemias Are Pan-Sensitive to Obatoclax Across molecular/Cytogenetic Subtypes, Especially MLL - ENL , and gene Expression Profiles Determine Obatoclax IC 50 : A Report on the Children's Oncology Group (COG) P9407 Trial

af9 Regulates gata2 Expression During Early Hemangioblast Specification and Vascular Pattern Formation In Zebrafish.

Gene Expression Profiling Reveals Genes Predictive of Outcome In Infant Acute Lymphoblastic Leukemia (ALL) and Distinctive Age-Related Gene Expression Profiles (< 90 Days vs. > 90 Days): A Children's Oncology Group Study

Zebrafish Mll Depletion Model Phenocopies Mammalian Mll Depletion and Implicates MLL as Master Regulator of Novel Developmental Hematopoietic Targets.

Specific MLL Partner Genes in Infant Acute Lymphoblastic Leukemia (ALL) Associated with Outcome Are Linked to Age and White Blood Cell Count (WBC) at Diagnosis: A Report On the Children's Oncology Group (COG) P9407 Trial.

Age Is the Strongest Determinant of Leukemia Blast Cell Gene Expression in MLL -Rearranged Infant ALL and MLL-AF4 Directs a Distinct Gene Expression Profile Related to CNS Disease.

Pan-Anti-Apoptotic BCL-2 Family Inhibitor, Obatoclax, Activates Autophagic Cell Death Pathway and Has Potent Cytotoxicity in Infant and Pediatric MLL -Rearranged Leukemias

Cell Death Regulatory Gene Expression Correlates with MLL Rearrangement Status and Prognostic Clinical Covariates in Acute Leukemia in Infants.

Cloning and Characterization of the Zebrafish mll Ortholog.

Congenital Amniotic Band Syndrome and MLL Rearranged Neonatal Leukemia in an Infant with Multiple Pre-Conception and In Utero Exposures.

DNA Topoisomerase II Poisons and the Etiology of Acute Leukemia in Infants.

Pre-Clinical In Vitro Evaluation of BCL-2 Antisense Compound Genasense TM (G3139; Genta, Inc.) as a Targeted Pro-Apoptotic Agent for Leukemias with t(4;11)(q21;q23) Translocations.

Pan-BCL-2 Family Small Molecule Inhibitor GX015-070 (GeminX, Inc.) Exhibits Single Agent Cytotoxicity, Is Synergistic with Select Anti-Leukemia Cytotoxic Agents, and Induces Apoptosis in Cell Lines with t(4;11)(q21;q23) Translocations.

Philadelphia Chromosome (Ph’) Negative, MLL -Rearranged AML Arising in a Patient Treated with Imatinib for CML.

Cryptic MLL , AF10 , ARMC3 Rearrangement in Secondary AML Creates ARMC3-MLL Fusion That Disrupts Gene Encoding Armadillo Repeats Similar to Major Cancer Genes.

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American Society of Hematology

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American Society of Hematology

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