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Bruce A. Keyt
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Journal Articles

Novel CD123xCD3 Bispecific Igm Antibody, Igm-2537, Potently Induces T-Cell Mediated Cytotoxicity of Acute Myeloid Leukemia Cells In Vivo and in Vitro with Minimal Cytokine Release

Gene Li, Zhongde Ye, Poonam Yakkundi, Marigold Manlusoc, Kathryn Logronio, Leyla Tahrani, Rodnie Rosete, David Bernados, Paul Hinton, Deepal Pandya, Nardeen Hanna, Jey Anantam, Maya F Kotturi, Liz Bogaert, Jiyoung Hong, Christina Tsai, Thomas Manley, Bruce A Keyt, Angus M. Sinclair, Liqin Liu
Journal: Blood
Blood (2023) 142 (Supplement 1): 4177.
https://doi.org/10.1182/blood-2023-182891
Published: 2023
Journal Articles

CD123 Directed IgM Antibody-based T-cell Engager, IGM-2537, Demonstrates Potent in vitro and in vivo Activity with Minimal Cytokine Release

Liqin Liu, Gene Li, Ling Wang, Poonam Yakkundi, Paul R. Hinton, Deepal Pandya, Manal Amoury, Keerthana Sekar, Chian Liu, Rodnie Rosete, Nardeen Hanna, Maya F. Kotturi, Liz Bogaert, Jiyoung Hong, Christina Tsai, Bruce A. Keyt, Angus M. Sinclair
Journal: Blood
Blood (2022) 140 (Supplement 1): 5918–5919.
https://doi.org/10.1182/blood-2022-165817
Published: 2022
Journal Articles

Igm-2644, a Novel CD38xCD3 Bispecific IgM T Cell Engager Demonstrates Potent Efficacy on Myeloma Cells with an Improved Preclinical Safety Profile

Keyu Li, Rui Yun, Min Chai, Poonam Yakkundi, Rodnie Rosete, Gene Li, Liqin Liu, Dean Ng, Paul R. Hinton, Maya F. Kotturi, Angus M. Sinclair, Stephen F. Carroll, Umesh Muchhal, Bruce A. Keyt
Journal: Blood
Blood (2022) 140 (Supplement 1): 6010–6011.
https://doi.org/10.1182/blood-2022-159205
Published: 2022
Journal Articles

Pharmacodynamics and Biomarker Correlates of Imvotamab (IGM-2323), the First-in-Class CD20xCD3 Bispecific IgM Antibody with Dual Mechanisms of Action, in Patients with Advanced B Cell Malignancies

Genevive H. Hernandez, John So, Kathryn A. Logronio, Maya F. Kotturi, Won Seog Kim, Philippe Armand, Chan Y. Cheah, Ajay K. Gopal, Ian W. Flinn, Gareth P. Gregory, Matthew J. Matasar, Loretta J. Nastoupil, Catherine S. Diefenbach, Sung-Soo Yoon, Matthew Ku, Ibrahim Qazi, Maya K. Leabman, Iris Sison, Bruce A. Keyt, Chris H. Takimoto, Thomas J. Manley, Elizabeth L. Budde
Journal: Blood
Blood (2022) 140 (Supplement 1): 6436–6438.
https://doi.org/10.1182/blood-2022-163235
Published: 2022
Journal Articles

A Phase 1 Dose Escalation Study of Igm-2323, a Novel Anti-CD20 x Anti-CD3 IgM T Cell Engager (TCE) in Patients with Advanced B-Cell Malignancies

Elizabeth Budde, Ajay K Gopal, Won Seog Kim, Ian W. Flinn, Chan Yoon Y. Cheah, Loretta Nastoupil, Matthew J. Matasar, Catherine S. Diefenbach, Gareth P Gregory, Ibrahim Qazi, Ching-Fai Pang, Maya Leabman, Genevive Hernandez, Iris Sison, Bruce A. Keyt, Daniel Chen, Philippe Armand
Journal: Blood
Blood (2021) 138 (Supplement 1): 132.
https://doi.org/10.1182/blood-2021-153355
Published: 2021
Journal Articles

The Anti-Tumor Activity of Igm-8444, an Agonistic Death Receptor 5 (DR5) IgM Antibody, Is Sensitized in Combination with Chemotherapy and Bcl-2 Inhibitors in NHL and AML

Beatrice T. Wang, PhD, Thomas J. Matthew, PhD, Ling Wang, MS, Tasnim Kothambawala, Susan E. Calhoun, MS, Eric W. Humke, MD, Angus M. Sinclair, PhD, Bruce A. Keyt, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 43–44.
https://doi.org/10.1182/blood-2020-141449
Published: 2020