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Journal Articles

Factor VIII Proteins Having a Rationally Modified, Immunodominant T-Cell Epitope Demonstrate Normal Procoagulant Activity, Bind To VWF With High Affinity, and Are Markedly Less Stimulatory To FVIII-Specific Human T Cells

Ruth A. Ettinger, Ph.D., Eddie A. James, Ph.D., Komal Puranik, M.Sc., Arthur R. Thompson, M.D., Ph.D., Dana C. Matthews, M.D., Kathleen P. Pratt, Ph.D.

Blood (2013) 122 (21): 574.

https://doi.org/10.1182/blood.V122.21.574.574

Published: 2013

Journal Articles

Reduced Immunogenicity of FVIII Peptides by Rational Modifications of An Immunodominant T-Cell Epitope.

Ruth A. Ettinger, Ph.D., Joseph A. Liberman, B.S., Douglas C. Bolgiano, M.S., Arthur R. Thompson, M.D., Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2009) 114 (22): 220.

https://doi.org/10.1182/blood.V114.22.220.220

Published: 2009

Journal Articles

Risk Factors for Inhibitor Development in Mild and Moderate Hemophilia A: A Case-Control Study.

Christine L Kempton, MD, MSc, J. Michael Soucie, Ph.D, Connie H. Miller, PhD, Craig Hooper, PhD, Miguel A. Escobar, MD, Mark T. Reding, MD, Alice J. Cohen, MD, Nigel S. Key, MBChB, Arthur R. Thompson, M.D., Ph.D., Marilyn J. Manco-Johnson, Thomas C. Abshire, MD

Blood (2009) 114 (22): 3184.

https://doi.org/10.1182/blood.V114.22.3184.3184

Published: 2009

Journal Articles

A FVIII C1 Domain Loop Containing Phe2093 Contributes Affinity to the Binding of Recombinant FVIII C1C2 Proteins to Activated Platelets

Ting-Chang Hsu, Ph.D., Kathleen P. Pratt, Ph.D., Arthur R. Thompson, M.D., Ph.D.

Blood (2008) 112 (11): 3069.

https://doi.org/10.1182/blood.V112.11.3069.3069

Published: 2008

Journal Articles

Six Amino Acid Residues in a 1200 Å 2 Interface Mediate Binding of Factor VIII to An IgG4 Inhibitory Antibody.

Jasper C. Lin, Ph.D., Jason T. Schuman, Ph.D., Shelley M. Nakaya, Vasudha Kaushik, Marc Jacquemin, Ph.D., Arthur R. Thompson, M.D., Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2008) 112 (11): 3380.

https://doi.org/10.1182/blood.V112.11.3380.3380

Published: 2008

Journal Articles

Identification of Specific Residues in a Human FVIII T-Cell Epitope That Are Essential for An HLA-DRA-DRB1*0101-Restricted T-Cell Response Associated with Inhibitor Development.

Joseph A. Liberman, Ruth A. Ettinger, Ph.D., Arthur R. Thompson, M.D., Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2008) 112 (11): 3396.

https://doi.org/10.1182/blood.V112.11.3396.3396

Published: 2008

Journal Articles

B-Cell Epitope Mapping of Monoclonal Anti-Factor VIII C2 Domain Inhibitors: Identification of Amino Acids That Contribute Significant Antigen-Antibody Binding Affinity.

Jasper C. Lin, Ph.D., Jason T. Schuman, Ph.D., Shannon L. Meeks, M.D., John F. Healey, Arthur R. Thompson, M.D., Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2008) 112 (11): 1211.

https://doi.org/10.1182/blood.V112.11.1211.1211

Published: 2008

Journal Articles

HLA-DRB1*1101-Restricted T Cells from Two Unrelated Mild Hemophilia a Inhibitor Subjects with Missense Genotype R593C Respond to the Same Minimal Epitope.

Eddie A. James, Ph.D., Simon D. van Haren, Ruth A. Ettinger, Ph.D., Arthur R. Thompson, M.D., Ph.D., William W. Kwok, Ph.D., Jan Voorberg, Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2008) 112 (11): 1212.

https://doi.org/10.1182/blood.V112.11.1212.1212

Published: 2008

Journal Articles

IL-17 Is Secreted by T-Cell Clones Isolated Following An Initial Peak Inhibitor Response to Factor VIIII, Suggesting Th17 Cells Play a Role in Inhibitor Development

Ruth A. Ettinger, Ph.D., Eddie James, Ph.D., William W. Kwok, Ph.D, Arthur R. Thompson, M.D., Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2008) 112 (11): 244.

https://doi.org/10.1182/blood.V112.11.244.244

Published: 2008

Journal Articles

Epitope Identification and Generation of an Antigen-Specific T-Cell Clone in a Mild Hemophilia A Inhibitor Subject with Missense Genotype R593C.

Eddie A. James, PhD, Simon D. van Haren, Ruth A. Ettinger, Ph.D., Arthur R. Thompson, M.D., Ph.D., William W. Kwok, Ph.D., Jan Voorberg, Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2007) 110 (11): 1159.

https://doi.org/10.1182/blood.V110.11.1159.1159

Published: 2007

Journal Articles

Regulatory CD4+CD25+ T Cells Modulated the Immune Response of a Mild Hemophilia A Subject to an Immunodominant FVIII Epitope within a Distinct Time Window.

Eddie A. James, PhD, William W. Kwok, Ph.D., Arthur R. Thompson, M.D., Ph.D., Kathleen P. Pratt, PhD

Blood (2006) 108 (11): 764.

https://doi.org/10.1182/blood.V108.11.764.764

Published: 2006

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Factor VIII Proteins Having a Rationally Modified, Immunodominant T-Cell Epitope Demonstrate Normal Procoagulant Activity, Bind To VWF With High Affinity, and Are Markedly Less Stimulatory To FVIII-Specific Human T Cells

Reduced Immunogenicity of FVIII Peptides by Rational Modifications of An Immunodominant T-Cell Epitope.

Risk Factors for Inhibitor Development in Mild and Moderate Hemophilia A: A Case-Control Study.

A FVIII C1 Domain Loop Containing Phe2093 Contributes Affinity to the Binding of Recombinant FVIII C1C2 Proteins to Activated Platelets

Six Amino Acid Residues in a 1200 Å 2 Interface Mediate Binding of Factor VIII to An IgG4 Inhibitory Antibody.

Identification of Specific Residues in a Human FVIII T-Cell Epitope That Are Essential for An HLA-DRA-DRB1*0101-Restricted T-Cell Response Associated with Inhibitor Development.

B-Cell Epitope Mapping of Monoclonal Anti-Factor VIII C2 Domain Inhibitors: Identification of Amino Acids That Contribute Significant Antigen-Antibody Binding Affinity.

HLA-DRB1*1101-Restricted T Cells from Two Unrelated Mild Hemophilia a Inhibitor Subjects with Missense Genotype R593C Respond to the Same Minimal Epitope.

IL-17 Is Secreted by T-Cell Clones Isolated Following An Initial Peak Inhibitor Response to Factor VIIII, Suggesting Th17 Cells Play a Role in Inhibitor Development

Epitope Identification and Generation of an Antigen-Specific T-Cell Clone in a Mild Hemophilia A Inhibitor Subject with Missense Genotype R593C.

Regulatory CD4+CD25+ T Cells Modulated the Immune Response of a Mild Hemophilia A Subject to an Immunodominant FVIII Epitope within a Distinct Time Window.

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