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Angelo D'alessandro, PhD
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Journal Articles

Evolution of Gilteritinib Resistance from Residual Disease to Relapse

Sunil K Joshi, BA, Tamilla Nechiporuk, PhD, Daniel Bottomly, Paul Piehowski, Paul.Piehowski@pnnl.gov, Julie Reisz, PhD, Janét Pittsenbarger, BA, Sara J Gosline, Andy Kaempf, MS, Yi-Ting Wang, Jamie Moon, Özgün Babur, Kevin M Watanabe-Smith, PhD, Emek Demir, Liu Tao, BS, PhD, Cristina E. Tognon, PhD, Angelo D'Alessandro, PhD, Jeffrey W. Tyner, PhD, Shannon K. McWeeney, PhD, Karin Rodland, rodland@ohsu.edu, Brian J. Druker, MD, Elie Traer
Journal: Blood
Blood (2020) 136 (Supplement 1): 4–5.
https://doi.org/10.1182/blood-2020-139084
Published: 2020
Journal Articles

Nicotinamide Phosphoribosyltransferase Inhibitors Induce Apoptosis of AML Stem Cells through Dysregulation of Lipid Metabolism

Amit Subedi, PhD, Qiang Liu, PhD BSc, David Sharon, PhD, Severine Cathelin, PhD, Gary D Bader, Changjiang Xu, Veronique Voisin, PhD, Angelo D'Alessandro, PhD, Eric R Lechman, PhD, John E. Dick, PhD FRS, Mark D. Minden, Jean C.Y. Wang, MD, Steven M Chan, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–26.
https://doi.org/10.1182/blood-2020-142404
Published: 2020
Journal Articles

Liver X Receptor (LXR) Is a Novel and Reversible Regulator of Trauma-Induced Coagulopathy

Peter Einersen, Sanchayita Mitra, Reid Selby, Ernest E. Moore, MD, Marguerite Kelher, Miguel Fragoso, Daran Schiller, Megan Swope, Geoffrey Nunns, Navin Vigneshwar, James Chandler, Arsen Ghasabayan, John Desisto, Bridget Sanford, Monika Dzieciatkowska, PhD, Linda Johnson, Mitchell J. Cohen, MD, Angelo D'Alessandro, PhD, Erik Peltz, Anirban Banerjee, PhD, Kirk Hansen, Christopher C. Silliman, MDPhD, Kenneth Jones
Journal: Blood
Blood (2020) 136 (Supplement 1): 2.
https://doi.org/10.1182/blood-2020-143292
Published: 2020
Journal Articles

Differential Metabolomics and Lipidomics of Hypoxic/Hypocapnic Long-Term Stored Red Cells Associate with Improved 24-Hour Recovery after Transfusion

Tatsuro Yoshida, PhD, Angelo D'Alessandro, PhD, Xiaoyun Fu, PhD, Travis Nemkov, PhD, Davide Stefanoni, Michael Dioguardi, BS, Neeta Rugg, Shawnagay Nestheide, BS, William Iselin, BA, Andrew Dunham, PhD, James C. Zimring, MD PhD, Jose A Cancelas, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4994.
https://doi.org/10.1182/blood-2019-125961
Published: 2019
Journal Articles

Linking Stored Red Blood Cell Metabolism to Transfusion Recipient Iron Homeostasis Pathophysiology in Critically-Ill Children

Ryan M. Fredericks, MD, Travis Nemkov, PhD, Camilla L'Acqua, MD, Steven L. Spitalnik, MD, Eldad A. Hod, MD, Angelo D'Alessandro, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1175.
https://doi.org/10.1182/blood-2019-125854
Published: 2019
Journal Articles

Leukemia Stem Cells in Relapsed AML Patients Are Uniquely Dependent on Nicotinamide Metabolism

Courtney L Jones, PhD, Brett M Stevens, PhD, Rachel Culp-Hill, BS, Travis Nemkov, Angelo D'Alessandro, PhD, Shanshan Pei, PhD, Daniel A Pollyea, MD, Craig T Jordan, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 429.
https://doi.org/10.1182/blood-2018-99-111366
Published: 2018
Journal Articles

Relapsed Acute Myeloid Leukemia Is Less Sensitive to Venetoclax + Azacitidine Due to Leukemia Stem Cell Resistance Driven By Fatty Acid Metabolism and Can be Overcome By Pharmacologic Inhibition of CPT1

Daniel A Pollyea, MD, Courtney L Jones, PhD, Brett M Stevens, PhD, Shanshan Pei, PhD, Angelo D'Alessandro, PhD, Rachel Culp-Hill, BS, Diana Abbott, PhD, Andrew Hammes, MS, James Dugan, MD, Jonathan A Gutman, MD, Enkhtsetseg Purev, MD PhD, Clayton Smith, MD, Craig T Jordan, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 432.
https://doi.org/10.1182/blood-2018-99-111507
Published: 2018
Journal Articles

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

Courtney L Jones, PhD, Brett M Stevens, PhD, Angelo D'Alessandro, PhD, Julia Reisz, PhD, Rachel Culp-Hill, BS, Travis Nemkov, Shanshan Pei, PhD, Nabilah Khan, Biniam Adane, PhD, Haobin Ye, PhD, Dominik Reinhold, Clayton Smith, MD, James DeGregori, PhD, Daniel A Pollyea, MD, Craig T Jordan, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1521.
https://doi.org/10.1182/blood-2018-99-111965
Published: 2018
Journal Articles

Adenosine A2B Receptor Controls Erythroid Lineage Commitment in Stress Erythropoiesis By Promoting Metabolic Reprogramming

Hong Liu, MD, Rongrong Liu, Travis Nemkov, Jacob Couturier, PhD, Long Liang, Anren Song, PhD, Shushan Zhao, MD PhD, Kaiqi Sun, PhD, Morayo Adebiyi, PhD, Yuan Edward Wen, Alexander Wen, Jing Liu, PhD, Rodney Kellems, PhD, Angelo D'Alessandro, PhD, Michael Blackburn, PhD, Yang Xia, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 845.
https://doi.org/10.1182/blood-2018-99-114075
Published: 2018
Journal Articles

Increased Methylation of Deamidated Asparagines and Aspartates in Stored Red Blood Cells from Glucose 6-Phosphate Dehydrogenase-Deficient Blood Donors

Angelo D'Alessandro, PhD, Travis Nemkov, Julie Reisz, PhD, Monika Dzieciatkowska, PhD, Rachel Culp-Hill, BS, Davide Stefanoni, Tatsuro Yoshida, PhD, Andrew Dunham, PhD, Tamir Kanias, PhD, Larry J. DuMont, PhD MBA, Michael Paul Busch, MD PhD, Elan Z Eisenmesser, Kirk C Hansen, Xiaoyun Fu, PhD, Tiffany Thomas, PhD, Matthew Karafin, MD, Eldad A. Hod, MD, Richard O Francis, MD PhD, Steven L Spitalnik, PhD, James C. Zimring, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2543.
https://doi.org/10.1182/blood-2018-99-119262
Published: 2018
Journal Articles

Elevated Circadian Period 2: A Missing Beneficial Factor in Sickle Cell Disease By Lowering Pulmonary Inflammation, Iron Overload and Mortality

Morayo Adebiyi, PhD, Zhaoyang Zhao, PhD, Jeanne Manalo, BS, Cheng Chi Lee, PhD, Wa Xian, PhD, Ye Youqiong, PhD, Frank McKeon, PhD, Rachel Culp-Hill, BS, Angelo D'Alessandro, PhD, Rodney Kellems, PhD, Seung-Hee Yoo, PhD, Leng Han, PhD, Yang Xia, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3644.
https://doi.org/10.1182/blood-2018-99-111211
Published: 2018
Journal Articles

Regulation of Mature Erythrocyte Proteasomal Machinery Under Hypoxia

Anren Song, PhD, Angelo D'Alessandro, PhD, Kaiqi Sun, PhD, Hong Liu, MD, Zhangzhe Peng, MD, Modupe Idowu, MD, Rodney Kellems, PhD, Harinder S. Juneja, MD, Yang Xia, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3616.
https://doi.org/10.1182/blood-2018-99-113050
Published: 2018
Journal Articles

Adenosine Signaling Regulates Erythroid Commitment Via Modulation of Metabolic Reprogramming in Stress Erythropoiesis

Liu Hong, MD PhD, Travis Nemkov, Rongrong Liu, Jacob Couturier, PhD, Ye Youqiong, PhD, Angelo D'Alessandro, PhD, Anren Song, PhD, Shushan Zhao, MD PhD, Kaiqi Sun, PhD, Adebiyi Morayo, Yuan Edward Wen, Alexander Wen, Hansen Kirk C., PhD, Leng Han, PhD, Dorothy E. Lewis, PhD, Xian Wa, PhD, Holger K. Eltzschig, MD PhD, Michael Blackburn, PhD, Rodney Kellems, PhD, Yang Xia, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1156.
https://doi.org/10.1182/blood.V130.Suppl_1.1156.1156
Published: 2017
Journal Articles

Metabolic Abnormalities in G6PC3 Deficient Human Neutrophils Result in Severe Functional Defects

Christopher M. McKinney, MD, Michael A. Ellison, PhD, Natalie Briones, MS, Angelina Baroffio, MS, Julie A. Reisz, PhD, Angelo D'alessandro, PhD, Daniel R. Ambruso, MD
Journal: Blood
Blood (2016) 128 (22): 1024.
https://doi.org/10.1182/blood.V128.22.1024.1024
Published: 2016
Journal Articles

Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease

Kaiqi Sun, BS, Yang Xia, MD PhD, Angelo D'Alessandro, PhD, Mostafa H Ahmed, PhD, Yujin Zhang, MD, Anren Song, PhD, Tzu-Ping KO, Travis Nemkov, Julie Haines, Hongyu Wu, PhD, Morayo G. Adebiyi, BS, Hong Liu, MD, Aji Huang, BS, MS, Zhangzhe Peng, MD, Yuan Edward Wen, Alexander Wen, Vladimir Berka, PhD, Mikhail Bogdanov, PhD, Osheiza Abdulmalik, DVM, MS, Gregory J Kato, MD, Ah-lim Tsai, Modupe Idowu, MD, Harinder S. Juneja, MD, Rodney E. Kellems, PhD, Kirk C Hansen, PhD, Martin K. Safo, PhD
Journal: Blood
Blood (2016) 128 (22): 2474.
https://doi.org/10.1182/blood.V128.22.2474.2474
Published: 2016
Journal Articles

Adenosine Signaling-Mediated Metabolic Reprogramming Regulates Erythropoiesis

Hong Liu, MD, Yujin Zhang, PhD, Angelo D'Alessandro, PhD, Travis Nemkov, Jacob Couturier, PhD, Shushan Zhao, PhD, Kirk C Hansen, PhD, Andrew T. Lovering, PhD, Robert Roach, PhD, Rodney E. Kellems, PhD, Holger K. Eltzschig, MD PhD, Michael R. Blackburn, PhD, Yang Xia, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2437.
https://doi.org/10.1182/blood.V128.22.2437.2437
Published: 2016
Journal Articles

Mitochondrial Fission 1 Regulates GSK3 and AMPK Signaling to Sustain Leukemia Stem Cell Function in Acute Myelogenous Leukemia

Shanshan Pei, PhD, Mohammad Minhajuddin, PhD, Biniam Adane, BS, Brett M Stevens, PhD, Nabilah Khan, PhD, Angelo D'alessandro, PhD, Travis Nemkov, Kirk C Hansen, PhD, Daniel A Pollyea, MD, Craig T Jordan, PhD
Journal: Blood
Blood (2016) 128 (22): 1703.
https://doi.org/10.1182/blood.V128.22.1703.1703
Published: 2016
Journal Articles

Regulation of Mitochondrial Morphology Is Important for Leukemia Stem Cell Function

Shanshan Pei, PhD, Mohammad Minhajuddin, PhD, Brett M Stevens, PhD, Biniam Adane, Nabilah Khan, PhD, Angelo D'alessandro, PhD, Travis Nemkov, Kirk C Hansen, PhD, Daniel Pollyea, MD MS, Craig T Jordan, PhD
Journal: Blood
Blood (2015) 126 (23): 842.
https://doi.org/10.1182/blood.V126.23.842.842
Published: 2015