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Journal Articles

Safety and Efficacy of the Contact Activation Inhibitor AB023 in Patients with End-Stage Renal Disease on Chronic Hemodialysis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial

Christina U Lorentz, PhD, Norah G Verbout, PhD, Joseph J Shatzel, MD, Michael Wallisch, PhD, Brandon D Markway, PhD, Monica T Hinds, PhD, Owen J T McCarty, PhD, David Gailani, MD, Jeffrey I. Weitz, MDFRCPC, Erik I Tucker, PhD, András Gruber, MD

Blood (2020) 136 (Supplement 1): 23–24.

https://doi.org/10.1182/blood-2020-139948

Published: 2020

Journal Articles

Safety and Antithrombotic Efficacy of the Recombinant Protein C Activator AB002 (E-WE Thrombin) in End Stage Renal Disease Patients on Chronic Hemodialysis

Norah G Verbout, PhD, Christina U Lorentz, PhD, Brandon D Markway, PhD, Joseph J Shatzel, MD, Erik I Tucker, PhD, Andras Gruber, MD

Blood (2019) 134 (Supplement_1): 2433.

https://doi.org/10.1182/blood-2019-124999

Published: 2019

Journal Articles

Antisense Oligonucleotide Targeting of Thrombopoietin Synthesis Reduces Platelet Count within the Hemostatic Range and Slows Progression of De Novo Mammary Carcinogenesis in the Mmtv-Pymt Mouse

Toshiaki Shirai, PhD, Alexey Revenko, PhD, Justin Tibbits, MS, Lisa M Coussens, PhD, Owen JT McCarty, PhD, Brett P. Monia, PhD, Andras Gruber, MD

Blood (2018) 132 (Supplement 1): 989.

https://doi.org/10.1182/blood-2018-99-114157

Published: 2018

Journal Articles

The Anti-Factor XII Antibody AB052 Is Antithrombotic without Hemostatic Impairment in a Primate Model of Extracorporeal Membrane Oxygenation

Michael Wallisch, PhD, Erik I Tucker, PhD, Christina U Lorentz, PhD, Jennifer Johnson, RLATG, Marschelle R Carris, BA, Owen JT McCarty, PhD, Monica T Hinds, PhD, András Gruber, MD

Blood (2017) 130 (Supplement 1): 236.

https://doi.org/10.1182/blood.V130.Suppl_1.236.236

Published: 2017

Journal Articles

FXIIa Differentially Regulates Thrombin Generation during Steady State and Vaso-Occlusive Crisis in Sickle Cell Mice

Erica M Sparkenbaugh, PhD, Camille Faes, PhD, Denis Noubouossie, MD PhD, Daniel K. Kirchhofer, PhD, András Gruber, MD, Nigel S. Key, MB, ChB, Rafal Pawlinski, PhD

Blood (2016) 128 (22): 162.

https://doi.org/10.1182/blood.V128.22.162.162

Published: 2016

Journal Articles

E-WE Thrombin (ProCase) Inhibits Thrombin Mediated TAFI Activation and Accelerates TPA-Induced Thrombolysis

Erik I Tucker, PhD, Brandon Markway, PhD, Michael Wallisch, PhD, Norah Green Verbout, PhD, Christina Lorentz, PhD, Marschelle Carris, Owen J.T. McCarty, PhD, Andras Gruber, MD

Blood (2016) 128 (22): 1390.

https://doi.org/10.1182/blood.V128.22.1390.1390

Published: 2016

Journal Articles

Distinct Mechanism of Anti-Hemophilic FVIII Activation By Nascent FXa in the Tissue Factor-FVIIa Coagulation Initiation Complex Resistant to FXa-Directed Inhibition

Yuichi Kamikubo, PhD, Grazia Loredana Mendolicchio, MD PhD, Antonella Zampolli, PhD, Patrizia Marchese, PhD, Andrew J. Gale, PhD, Sriram Krishnaswamy, PhD, Andras Gruber, MD, Lars Christian Petersen, Wolfram Ruf, MD, Zaverio M Ruggeri, MD

Blood (2014) 124 (21): 2803.

https://doi.org/10.1182/blood.V124.21.2803.2803

Published: 2014

Journal Articles

Inhibition of Factor XIIa-Mediated Factor XI Activation Reduces Infarct Size in a Mouse Model of Myocardial Ischemia and Reperfusion

Christina U Lorentz, PhD, Norah G Verbout, PhD, Zhiping Cao, Helen Liu, Owen J.T. McCarty, PhD, Erik I. Tucker, PhD, Andras Gruber, MD, Donna Van Winkle, PhD

Blood (2014) 124 (21): 2873.

https://doi.org/10.1182/blood.V124.21.2873.2873

Published: 2014

Journal Articles

Lack of Substantial Antithrombotic Effect of Low Circulating Coagulation Factor VII Levels in a Baboon Model of Acute Vascular Graft Thrombosis

Michael Wallisch, PhD, Greisel Jennifer, BS, Erik I Tucker, PhD, Owen J.T. McCarty, PhD, Monica T Hinds, PhD, Sue Murray, Jeff Crosby, PhD, Brett P. Monia, PhD, Andras Gruber, MD

Blood (2014) 124 (21): 1485.

https://doi.org/10.1182/blood.V124.21.1485.1485

Published: 2014

Journal Articles

Factor XI Deficiency Reduces The Inflammatory Response To Polymicrobial Sepsis In Mice

Charles E. Bane, jr., DVM, Kelli L. Boyd, DVM, Ph.D., Erik I. Tucker, Ph.D., Stephen T. Smiley, Ph.D., Andras Gruber, MD, David Gailani, MD

Blood (2013) 122 (21): 201.

https://doi.org/10.1182/blood.V122.21.201.201

Published: 2013

Journal Articles

Rapid Interruption Of Occlusive Thrombus Formation By The Protein C Activator Enzyme EWE Thrombin (ProCase) In Primates

Erik I Tucker, PhD, Michael Wallisch, PhD, Philberta Y Leung, PhD, Andras Gruber, MD, Enrico Di Cera, MD, Norah G Verbout, PhD

Blood (2013) 122 (21): 202.

https://doi.org/10.1182/blood.V122.21.202.202

Published: 2013

Journal Articles

Antibodies to Human Factor XII with Antithrombotic Properties

Anton Matafonov, MD, Adam E. Gailani, Stephanie L. Grach, Philberta Y Leung, PhD, Qiufang Cheng, MD, Yipeng Geng, Owen J.T. McCarty, PhD, Erik I Tucker, PhD, Thomas Renne, MD, PhD, James H. Morrissey, PhD, Andras Gruber, MD, David Gailani, MD

Blood (2012) 120 (21): 1106.

https://doi.org/10.1182/blood.V120.21.1106.1106

Published: 2012

Journal Articles

FXII Promotes Coagulation in a FXI and FIX Independent Manner

Cristina Puy, PhD, Zoë C Wong, Erik I Tucker, PhD, Andras Gruber, MD, David Gailani, MD, Stephanie A. Smith, DVM, MS, Sharon H. Choi, MS, James H. Morrissey, PhD, Owen J.T. McCarty, PhD

Blood (2012) 120 (21): 3362.

https://doi.org/10.1182/blood.V120.21.3362.3362

Published: 2012

Journal Articles

Antisense Oligonucleotide Mediated Depletion of Factor XI Prevents Vascular Occlusion in An Experimental Thrombosis Model in Primates

Jeff R. Crosby, PhD, Ulla M Marzec, MS, Chenguang Zhao, Dacao Gao, Alexey S Revenko, PhD, Anton Matafonov, MD, David Gailani, MD, Robert MacLeod, Ph.D., Andras Gruber, MD, Stephen Hanson, PhD, Brett P. Monia, PhD

Blood (2011) 118 (21): 2250.

https://doi.org/10.1182/blood.V118.21.2250.2250

Published: 2011

Journal Articles

Spatial Separation of TF-Carriers Modulates Procoagulant Activity of Circulating TF

Garth W Tormoen, MS, Andras Gruber, MD, Owen J.T. McCarty, PhD

Blood (2011) 118 (21): 2265.

https://doi.org/10.1182/blood.V118.21.2265.2265

Published: 2011

Journal Articles

Coagulation Factors XIa and XIIa Modulate Neutrophil Elastase Release,

Norah Verbout, PhD, Asako Itakura, Joseph Aslan, PhD, Erik Tucker, PhD, Andras Gruber, MD, Owen J.T. McCarty, PhD

Blood (2011) 118 (21): 3220.

https://doi.org/10.1182/blood.V118.21.3220.3220

Published: 2011

Journal Articles

Distinct Roles of the Extrinsic and the Intrinsic Coagulation Pathways In Different Murine Thrombosis Models,

Antonella Zampolli, PhD, Patrizia Marchese, PhD, Andras Gruber, MD, Wolfram Ruf, MD, Zaverio M. Ruggeri, MD

Blood (2011) 118 (21): 3278.

https://doi.org/10.1182/blood.V118.21.3278.3278

Published: 2011

Journal Articles

Evidence for a Factor IX-Independent Role for Factor XI in Thrombin Generation

Anton Matafonov, MD, Qiufang Cheng, MD, Ingrid M. Verhamme, PhD, Obi Umunakwe, Erik I. Tucker, PhD, Mao-fu Sun, Andras Gruber, MD, David Gailani, MD

Blood (2011) 118 (21): 2244.

https://doi.org/10.1182/blood.V118.21.2244.2244

Published: 2011

Journal Articles

Apple Domain-Specific Anti-Factor XI Antibodies Inhibit Venous-Type Thrombosis with Improved Hemostatic Safety Profiles Compared to Enoxaparin in Primates

Erik I. Tucker, PhD, Ulla M Marzec, MS, Philberta Y Leung, PhD, Stephen R Hanson, PhD, Prof., Norah G Verbout, PhD, Sawan Hurst, MS, Owen J.T. McCarty, PhD, David Gailani, MD, Andras Gruber, MD

Blood (2011) 118 (21): 1173.

https://doi.org/10.1182/blood.V118.21.1173.1173

Published: 2011

Journal Articles

Factor XI Inhibitor Antibody Treatment Improves Survival In a Murine Polymicrobial Sepsis Model

Erik I Tucker, PhD, Melani Helm, BS, Owen JT McCarty, PhD, Sawan Hurst, MS, David Gailani, MD, Andras Gruber, MD

Blood (2010) 116 (21): 820.

https://doi.org/10.1182/blood.V116.21.820.820

Published: 2010

NARROW

Safety and Efficacy of the Contact Activation Inhibitor AB023 in Patients with End-Stage Renal Disease on Chronic Hemodialysis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial

Safety and Antithrombotic Efficacy of the Recombinant Protein C Activator AB002 (E-WE Thrombin) in End Stage Renal Disease Patients on Chronic Hemodialysis

Antisense Oligonucleotide Targeting of Thrombopoietin Synthesis Reduces Platelet Count within the Hemostatic Range and Slows Progression of De Novo Mammary Carcinogenesis in the Mmtv-Pymt Mouse

The Anti-Factor XII Antibody AB052 Is Antithrombotic without Hemostatic Impairment in a Primate Model of Extracorporeal Membrane Oxygenation

FXIIa Differentially Regulates Thrombin Generation during Steady State and Vaso-Occlusive Crisis in Sickle Cell Mice

E-WE Thrombin (ProCase) Inhibits Thrombin Mediated TAFI Activation and Accelerates TPA-Induced Thrombolysis

Distinct Mechanism of Anti-Hemophilic FVIII Activation By Nascent FXa in the Tissue Factor-FVIIa Coagulation Initiation Complex Resistant to FXa-Directed Inhibition

Inhibition of Factor XIIa-Mediated Factor XI Activation Reduces Infarct Size in a Mouse Model of Myocardial Ischemia and Reperfusion

Lack of Substantial Antithrombotic Effect of Low Circulating Coagulation Factor VII Levels in a Baboon Model of Acute Vascular Graft Thrombosis

Factor XI Deficiency Reduces The Inflammatory Response To Polymicrobial Sepsis In Mice

Rapid Interruption Of Occlusive Thrombus Formation By The Protein C Activator Enzyme EWE Thrombin (ProCase) In Primates

Antibodies to Human Factor XII with Antithrombotic Properties

FXII Promotes Coagulation in a FXI and FIX Independent Manner

Antisense Oligonucleotide Mediated Depletion of Factor XI Prevents Vascular Occlusion in An Experimental Thrombosis Model in Primates

Spatial Separation of TF-Carriers Modulates Procoagulant Activity of Circulating TF

Coagulation Factors XIa and XIIa Modulate Neutrophil Elastase Release,

Distinct Roles of the Extrinsic and the Intrinsic Coagulation Pathways In Different Murine Thrombosis Models,

Evidence for a Factor IX-Independent Role for Factor XI in Thrombin Generation

Apple Domain-Specific Anti-Factor XI Antibodies Inhibit Venous-Type Thrombosis with Improved Hemostatic Safety Profiles Compared to Enoxaparin in Primates

Factor XI Inhibitor Antibody Treatment Improves Survival In a Murine Polymicrobial Sepsis Model

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American Society of Hematology

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ASH Publications

American Society of Hematology

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