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Journal Articles

Optimization of Dose Regimen for ALXN1210, a Novel Complement C5 Inhibitor, in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH): Results of 2 Phase 1/2 Studies

Alexander Roeth, MD, Scott T. Rottinghaus, MD, Anita Hill, MBChB (Hons), PhD, Jin Seok Kim, MD PhD, Hubert Schrezenmeier, MD, Louis Terriou, MD, Alvaro Urbano-Ispizua, MD, Richard A. Wells, MD DPhil, Jun Ho Jang, MD PhD, Jeff Szer, MB, BS, FRACP, Rasha Aguzzi, MS, Eric Scott Bachman, MD PhD, Andrew I. Damokosh, PhD, Lori Shafner, PhD, Jong-Wook Lee, MD

Blood (2017) 130 (Supplement 1): 3482.

https://doi.org/10.1182/blood.V130.Suppl_1.3482.3482

Published: 2017

Journal Articles

Interim Analysis of Safety Outcomes during Treatment with Eculizumab: Results from the International Paroxysmal Nocturnal Hemoglobinuria Registry

Anita Hill, MBChB (Hons), PhD, Alexander Roeth, MD, Gérard Socié, MDPhD, Marie-Pierre Caby-Tosi, PharmD, PhD, Amanda Wilson, MPH, PhD, Philippe Gustovic, MD, Camille L. Bedrosian, MD, Robert A. Brodsky, MD

Blood (2017) 130 (Supplement 1): 3486.

https://doi.org/10.1182/blood.V130.Suppl_1.3486.3486

Published: 2017

Journal Articles

Efficacy of Eculizumab in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) and High Disease Activity with or without History of Aplastic Anemia in the International PNH Registry

Jong-Wook Lee, MD, Regis Peffault De Latour, MD PhD, Robert A. Brodsky, MD, Jun Ho Jang, MD PhD, Anita Hill, MBChB (Hons), PhD, Alexander Roeth, MD, Hubert Schrezenmeier, MD, Amanda Wilson, MPH, PhD, Jing L. Marantz, MD PhD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 3487.

https://doi.org/10.1182/blood.V130.Suppl_1.3487.3487

Published: 2017

Journal Articles

Analysis of Baseline Clinical Characteristics and Disease Burden in Patients Enrolled in the International Paroxysmal Nocturnal Hemoglobinuria Registry

Hubert Schrezenmeier, MD, Jaroslaw P. Maciejewski, PhD MD FACP, Alexander Roeth, MD, David J. Araten, MD, Yuzuru Kanakura, MD PhD, Loree Larratt, MD FRCP(C), Jamile M. Shammo, MD FASCP, FACP, Amanda Wilson, MPH, PhD, Gilda Shayan, Peter Hillmen, MBChB, PhD

Blood (2017) 130 (Supplement 1): 3488.

https://doi.org/10.1182/blood.V130.Suppl_1.3488.3488

Published: 2017

Journal Articles

The SMART-IgG Anti-hC5 Antibody (SKY59/RO7112689) Has Favorable PK, PD, Subcutaneous Bioavailability, and Safety Profile in Phase I HV Study

Alexander Roeth, MD, Nagy Zsolt, MD PhD, Miklos Egyed, MD, Erica Winter, Joy Hsu, Andreas Dieckmann, Judith Anzures-Cabrera, Marie Mannino, Elana Fernandez, PhD, Gregor Jordan, Barbara Klughammer, PhD, Kenji Shinomiya, Naoki Kotani, Ido Paz-Priel, MD, Angelika Jahreis., MD, PhD

Blood (2017) 130 (Supplement 1): 4750.

https://doi.org/10.1182/blood.V130.Suppl_1.4750.4750

Published: 2017

Journal Articles

Dynamics of Mutations in Patients with ET Treated with Imetelstat

Elisabeth Oppliger Leibundgut, PharmD, Monika Haubitz, PhD, Bart Burington, PhD, Oliver G. Ottmann, MD, Gary Spitzer, MD, Olatoyosi Odenike, MD, Michael A McDevitt, MD PhD, Alexander Roeth, MD, David S. Snyder, MD, Gabriela M. Baerlocher, MD

Blood (2015) 126 (23): 57.

https://doi.org/10.1182/blood.V126.23.57.57

Published: 2015

Journal Articles

Monitoring of Calr Allele Burden in Patients with Essential Thrombocythemia Treated with Imetelstat, a Telomerase Inhibitor, Reveals Rapid and Substantial Molecular Responses

Gabriela M. Baerlocher, MD, Monika Haubitz, PhD, Oliver G. Ottmann, MD, Olatoyosi Odenike, MBBS, Alexander Roeth, MD, Michael A McDevitt, MD PhD, Ted Shih, Bart Burington, Dianne Morfeld, Neeru Batra, BS, David Snyder, MD, Elisabeth Oppliger Leibundgut, PharmD

Blood (2014) 124 (21): 408.

https://doi.org/10.1182/blood.V124.21.408.408

Published: 2014

Journal Articles

Serologic Response to Meningococcal Vaccination in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) for the Chronic Treatment with the Terminal Complement Inhibitor Eculizumab

Alexander Roeth, MD, Ferras Alashkar, MD, Doerte Herich-Terhuerne, Johannes Elias, MD, Ulrich Vogel, MD, Ulrich Duehrsen

Blood (2014) 124 (21): 4380.

https://doi.org/10.1182/blood.V124.21.4380.4380

Published: 2014

Journal Articles

Development Of a Disease Specific Quality Of Life Questionnaire For Patients With Aplastic Anemia and/Or Paroxysmal Nocturnal Hemoglobinuria (QLQ-AA/PNH)

Martha Groth, Susanne Singer, PhD, Cathrin Niedeggen, Andrea Petermann-Meyer, MD, Alexander Roeth, MD, Hubert Schrezenmeier, MD, Britta Höchsmann, MD, Tim H. Brümmendorf, MD, Jens Panse, MD

Blood (2013) 122 (21): 1680.

https://doi.org/10.1182/blood.V122.21.1680.1680

Published: 2013

Journal Articles

Imetelstat Rapidly Induces and Maintains Substantial Hematologic and Molecular Responses in Patients with Essential Thrombocythemia (ET) Who Are Refractory or Intolerant to Prior Therapy: Preliminary Phase II Results

Gabriela M. Baerlocher, MD, Elisabeth Oppliger Leibundgut, PharmD, Christina Ayran, Martha Blaney, PharmD, Bart Burington, Ph.D, Dianne Morfeld, Olatoyosi Odenike, MD, Oliver Ottman, MD, Anita Reddy, PhD, Alexander Roeth, MD, Gary Spitzer, MD, Monic J. Stuart, MD, MPH, Srdan Verstovsek, MD, PhD, David S. Snyder, MD

Blood (2012) 120 (21): 179.

https://doi.org/10.1182/blood.V120.21.179.179

Published: 2012

Journal Articles

Long-Term Safety of Sustained Eculizumab Treatment in Patients with Paroxysmal Nocturnal Hemoglobinuria

Jeffrey Szer, MBBS, Petra Muus, MD, PhD, Alexander Roeth, MD, M.O Elebute, MD, FRCP, FRCPath, Antonio M. Risitano, MD, PhD, Hubert Schrezenmeier, MD, Jaroslaw P. Maciejewski, MD, PhD, Alvaro Urbano-Ispizua, MD, Carlos Manuel de Castro, III, MD, Gérard Socié, MD PhD, Robert A. Brodsky, MD

Blood (2012) 120 (21): 1260.

https://doi.org/10.1182/blood.V120.21.1260.1260

Published: 2012

Journal Articles

Sequential High Dose Immuno-Chemotherapy Followed by Autologous Peripheral Blood Stem Cell Transplantation for Patients with Untreated Primary Central Nervous System Lymphoma - a Multicentre Study by the Collaborative PCNSL Study Group Freiburg

Blood (2012) 120 (21): 302.

https://doi.org/10.1182/blood.V120.21.302.302

Published: 2012

Journal Articles

Expanded CLL CD8 + T-Cells Are Driven Into a Senescent KLRG1 + Effector Memory Phenotype

Joachim Rudolf Göthert, MD, Lewin Eisele, MD, Ludger Klein-Hitpass, Stefanie Weber, Anja Führer, Ludger Sellmann, MD, Alexander Roeth, MD, Ulrich Duehrsen, MD, Hanspeter Pircher, Jan Dürig

Blood (2010) 116 (21): 913.

https://doi.org/10.1182/blood.V116.21.913.913

Published: 2010

Journal Articles

Leukemic T-PLL Cells Exhibit Short and Narrowly Distributed Telomere Lengths and High Telomerase Activities, Associated with Rapid and Dose-Dependent Cell Death Following Telomerase Inhibition by Imetelstat Sodium.

Gabriela M. Baerlocher, MD, Katia Bassett, PhD, Dirk de Beer, Laurence Elias, MD, Ning F Go, MD, Alexander Roeth, MD

Blood (2009) 114 (22): 2647.

https://doi.org/10.1182/blood.V114.22.2647.2647

Published: 2009

Journal Articles

High Prevalence of TERT Mutations in Chronic Lymphocytic Leukemia

Mark Hills, Alexander Roeth, MD, Holger Nückel, MD, Doug Horsman, Jan Duerig, Randy D. Gascoyne, MD, Peter M. Lansdorp, MD, PhD

Blood (2008) 112 (11): 3126.

https://doi.org/10.1182/blood.V112.11.3126.3126

Published: 2008

Journal Articles

Shorter Telomeres Are Associated with the Unfavourable Chromosomal Aberrations Del 17p and Del 11q in Chronic Lymphocytic Leukemia (CLL)

Ludger Sellmann, MD, Dirk de Beer, Marius Bartels, Holger Nueckel, MD, Ulrich Duehrsen, MD, Jan Duerig, MD, Gabriela Baerlocher, MD, Alexander Roeth, MD

Blood (2008) 112 (11): 3131.

https://doi.org/10.1182/blood.V112.11.3131.3131

Published: 2008

Journal Articles

Long-Term Efficacy of the Terminal Complement Inhibitor Eculizumab in a Patient with Cold Agglutinin Disease (CAD)

Alexander Roeth, MD, Andreas Huettmann, MD, Ulrich Duehrsen, MD, Thomas Philipp, MD

Blood (2008) 112 (11): 2882.

https://doi.org/10.1182/blood.V112.11.2882.2882

Published: 2008

Journal Articles

Effect of Reducing Intravascular Hemolysis on Ferritin Homeostasis in Eculizumab Treated Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients.

Alexander Roeth, MD, Joerg Schubert, MD, Christina Hock, Sandra Christoph, Ulrich Duehrsen, MD

Blood (2008) 112 (11): 3437.

https://doi.org/10.1182/blood.V112.11.3437.3437

Published: 2008

Journal Articles

Telomere Elongation in B-Cells Is Independent of Class Switching.

Alexander Roeth, MD, Dirk de Beer, Marc Seifert, Astrid Mueller, Ulrich Duehrsen, MD, Ralf Kueppers, PhD, Gabriela M. Baerlocher, MD

Blood (2008) 112 (11): 1542.

https://doi.org/10.1182/blood.V112.11.1542.1542

Published: 2008

Journal Articles

Significantly Shorter Telomeres in T-Cells of ZAP-70 + /CD38 + Patients with Chronic Lymphocytic Leukemia (CLL): An Important Role of T-Cells in This Subgroup of CLL?.

Alexander Roeth, MD, Dirk de Beer, Holger Nueckel, MD, Ludger Sellmann, MD, Ulrich Duehrsen, MD, Jan Duerig, MD, Gabriela M. Baerlocher, MD

Blood (2007) 110 (11): 1120.

https://doi.org/10.1182/blood.V110.11.1120.1120

Published: 2007

NARROW

Optimization of Dose Regimen for ALXN1210, a Novel Complement C5 Inhibitor, in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH): Results of 2 Phase 1/2 Studies

Interim Analysis of Safety Outcomes during Treatment with Eculizumab: Results from the International Paroxysmal Nocturnal Hemoglobinuria Registry

Efficacy of Eculizumab in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) and High Disease Activity with or without History of Aplastic Anemia in the International PNH Registry

Analysis of Baseline Clinical Characteristics and Disease Burden in Patients Enrolled in the International Paroxysmal Nocturnal Hemoglobinuria Registry

The SMART-IgG Anti-hC5 Antibody (SKY59/RO7112689) Has Favorable PK, PD, Subcutaneous Bioavailability, and Safety Profile in Phase I HV Study

Dynamics of Mutations in Patients with ET Treated with Imetelstat

Monitoring of Calr Allele Burden in Patients with Essential Thrombocythemia Treated with Imetelstat, a Telomerase Inhibitor, Reveals Rapid and Substantial Molecular Responses

Serologic Response to Meningococcal Vaccination in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) for the Chronic Treatment with the Terminal Complement Inhibitor Eculizumab

Development Of a Disease Specific Quality Of Life Questionnaire For Patients With Aplastic Anemia and/Or Paroxysmal Nocturnal Hemoglobinuria (QLQ-AA/PNH)

Imetelstat Rapidly Induces and Maintains Substantial Hematologic and Molecular Responses in Patients with Essential Thrombocythemia (ET) Who Are Refractory or Intolerant to Prior Therapy: Preliminary Phase II Results

Long-Term Safety of Sustained Eculizumab Treatment in Patients with Paroxysmal Nocturnal Hemoglobinuria

Sequential High Dose Immuno-Chemotherapy Followed by Autologous Peripheral Blood Stem Cell Transplantation for Patients with Untreated Primary Central Nervous System Lymphoma - a Multicentre Study by the Collaborative PCNSL Study Group Freiburg

Expanded CLL CD8 + T-Cells Are Driven Into a Senescent KLRG1 + Effector Memory Phenotype

Leukemic T-PLL Cells Exhibit Short and Narrowly Distributed Telomere Lengths and High Telomerase Activities, Associated with Rapid and Dose-Dependent Cell Death Following Telomerase Inhibition by Imetelstat Sodium.

High Prevalence of TERT Mutations in Chronic Lymphocytic Leukemia

Shorter Telomeres Are Associated with the Unfavourable Chromosomal Aberrations Del 17p and Del 11q in Chronic Lymphocytic Leukemia (CLL)

Long-Term Efficacy of the Terminal Complement Inhibitor Eculizumab in a Patient with Cold Agglutinin Disease (CAD)

Effect of Reducing Intravascular Hemolysis on Ferritin Homeostasis in Eculizumab Treated Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients.

Telomere Elongation in B-Cells Is Independent of Class Switching.

Significantly Shorter Telomeres in T-Cells of ZAP-70 + /CD38 + Patients with Chronic Lymphocytic Leukemia (CLL): An Important Role of T-Cells in This Subgroup of CLL?.

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American Society of Hematology

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American Society of Hematology

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