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Alex Tonks, PhD
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Journal Articles

PKC-Epsilon Overexpression Is Associated with Poor Outcomes in AML and Promotes Chemoresistance and Hematopoietic Stem Cell Quiescence

Rachael Louise Nicholson, BSc, Steven Knapper, DM, Alex Tonks, PhD, Richard L Darley, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2704.
https://doi.org/10.1182/blood-2019-128184
Published: 2019
Journal Articles

Overexpression or Deficiency of RUNX3 Results in Defective Normal Human Hematopoietic Development Similar to RUNX1-ETO Expression in AML

Ana Catarina Menezes, MSc, BSc, Steven Knapper, DM, Richard L Darley, PhD, Alex Tonks, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2527.
https://doi.org/10.1182/blood-2019-130798
Published: 2019
Journal Articles

Intracellular Thiol Oxidation Is Linked with Loss of Δψm and Disease Progression in Acute Promyelocytic Leukaemia

Alex J Wadley, PhD, Paul Hole, Alex Tonks, PhD, Richard Darley, PhD, Dr Omidvar, BSc, MSc, PhD, Rhys Gareth Morgan, PhD, Keane Gary, Steven John Coles, PhD BSc
Journal: Blood
Blood (2018) 132 (Supplement 1): 2751.
https://doi.org/10.1182/blood-2018-99-118646
Published: 2018
Journal Articles

CD200 and PD1-L1 in AML Are Associated with Expanded PD-1 + Late Differentiated CD8 + T Cells and a Decreased CD4:CD8 Ratio: a New Link Between Distinct Immunosuppressive Pathways

Steven Coles, PhD, Marie N Gilmore, PhD, Reiss Reid, PhD, Steven Knapper, DM BMBCh, Alan K. Burnett, MDFRCP, Steven Man, PhD, Alex Tonks, PhD, Richard L Darley, PhD
Journal: Blood
Blood (2014) 124 (21): 992.
https://doi.org/10.1182/blood.V124.21.992.992
Published: 2014
Journal Articles

Identification of the Wnt Signalling Protein, TCF7L2 As a Significantly Overexpressed Transcription Factor in AML

Siti Sarah Daud, MMedSc, Sara L Pumford, MPhil, Marie N Gilmour, PhD, Amanda F Gilkes, MSc, Alan K Burnett, MD, Robert Hills, MA, MSc, DPhil, Alex Tonks, PhD, Richard L Darley, PhD
Journal: Blood
Blood (2012) 120 (21): 1281.
https://doi.org/10.1182/blood.V120.21.1281.1281
Published: 2012
Journal Articles

Large-Scale Integration of Gene Profiling Identifies TCF7L2/TCF4 as the Most Frequently Dysregulated Wnt Signaling Component In AML

Siti Sarah Daud, Alan K Burnett, MD, Richard L Darley, PhD, Alex Tonks, PhD
Journal: Blood
Blood (2010) 116 (21): 2480.
https://doi.org/10.1182/blood.V116.21.2480.2480
Published: 2010
Journal Articles

PDK1 Overexpression In Acute Myeloid Leukemia; Clinical Significance and Potential as a Therapeutic Target

Joanna Zabkiewicz, PhD, Lorna Pearn, Robert Hills, MA, MSc, DPhil, Rhys, Gareth Morgan, BSc, Alan Burnett, MD, Alex Tonks, PhD, Richard L Darley, PhD
Journal: Blood
Blood (2010) 116 (21): 2162.
https://doi.org/10.1182/blood.V116.21.2162.2162
Published: 2010
Journal Articles

Distinct Regulation of β- and γ-Catenin throughout Hematopoietic Development Contrasts with Their Cooperative Roles In Acute Myeloid Leukemia.

Rhys Gareth Morgan, BSc, Lorna Pearn, Kate Liddiard, PhD, Robert Hills, MA, MSc, DPhil, Alan Burnett, MD, Alex Tonks, PhD, Richard L Darley, PhD
Journal: Blood
Blood (2010) 116 (21): 1573.
https://doi.org/10.1182/blood.V116.21.1573.1573
Published: 2010
Journal Articles

Over-Expression of CD200 In Acute Myeloid Leukemia Mediates the Expansion of Regulatory T-Lymphocytes and Directly Inhibits Natural Killer Cell Tumor Immunity

Steven J Coles, PhD, Stephen Man, PhD, Robert Hills, MA, MSc, DPhil, Eddie CY Wang, PhD, Alan Burnett, MD, Richard L Darley, PhD, Alex Tonks, PhD
Journal: Blood
Blood (2010) 116 (21): 491.
https://doi.org/10.1182/blood.V116.21.491.491
Published: 2010
Journal Articles

Ras Promotes Production of Reactive Oxygen Species in Normal Human CD34 + Cells: Role in Promoting Cell Survival and Protein Phosphorylation

Paul S Hole, BA, Lorna Pearn, Philip E James, PhD, Alan Burnett, MD, Richard L Darley, PhD, Alex Tonks, PhD
Journal: Blood
Blood (2008) 112 (11): 3797.
https://doi.org/10.1182/blood.V112.11.3797.3797
Published: 2008
Journal Articles

Expression of RUNX1-RUNX1T1 Alone Has No Effect on the Intrinsic Susceptibility to Cytotoxic Chemicals.

Alex Tonks, PhD, Lorna Pearn, Amanda Tonks, PhD, Ken I. Mills, PhD, Alan K. Burnett, MD, Richard L. Darley, PhD
Journal: Blood
Blood (2006) 108 (11): 2602.
https://doi.org/10.1182/blood.V108.11.2602.2602
Published: 2006
Journal Articles

RUNX1-RUNX1T1 Induces Over-Expression of γ-Catenin in Human CD34 + Cells, Increasing Self Renewal and Impairing Granulocytic Differentiation.

Alex Tonks, PhD, Lorna Pearn, Megan Musson, Amanda Gilkes, Ken Mills, PhD, Alan Burnett, MD, Richard Darley, PhD
Journal: Blood
Blood (2005) 106 (11): 3003.
https://doi.org/10.1182/blood.V106.11.3003.3003
Published: 2005