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Journal Articles

Pathways Relevant to AML Pathogenesis Targeting the Hematopoietic-Specific Cebpa +37 Kb Enhancer

Stacy Cooper, MD, Hong Guo, MD PhD, Justin Thomas, Jay L. Hess, MD PhD, Peter D. Aplan, MD, Donald Small, MD PhD, Alan D. Friedman, MD

Blood (2016) 128 (22): 2691.

https://doi.org/10.1182/blood.V128.22.2691.2691

Published: 2016

Journal Articles

The Roles of RUNX1 in Human Hematopoiesis and Megakaryopoiesis Revealed By Genome-Targeted Human iPSCs and an Improved Hematopoietic Differentiation Model

Bin-Kuan Chou, PhD, Hao Bai, PhD, Yongxing Gao, Ying Wang, Zhaohui Ye, PhD, Erika Mijin Kwon, PhD, Pu Paul Liu, MD PhD, Alan D. Friedman, MD, Zack Z. Wang, PhD, Linzhao Cheng, PhD

Blood (2015) 126 (23): 1167.

https://doi.org/10.1182/blood.V126.23.1167.1167

Published: 2015

Journal Articles

In Vivo Deletion of the Cebpa +37 Kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis

Alan D. Friedman, MD, Hong Guo, MD PhD, Stacy Cooper, MD

Blood (2015) 126 (23): 1178.

https://doi.org/10.1182/blood.V126.23.1178.1178

Published: 2015

Journal Articles

The Multimerization Domain of Cbfß-SMMHC Is Required for Leukemogenesis

Ling Zhao, MD PhD, Lemlem Alemu, Jun Cheng, Tao Zhen, PhD, Alan D. Friedman, MD, Pu Paul Liu, MD PhD

Blood (2015) 126 (23): 3666.

https://doi.org/10.1182/blood.V126.23.3666.3666

Published: 2015

Journal Articles

Functional Dissection of the C Terminus of CBFβ-SMMHC Indicates a Critical Role of the Multimerization Domain during Hematopoiesis and Leukemogenesis

Ling Zhao, MD PhD, Lemlem Alemu, Jun Cheng, Tao Zhen, PhD, Alan D. Friedman, MD, Pu Paul Liu, MD PhD

Blood (2014) 124 (21): 2218.

https://doi.org/10.1182/blood.V124.21.2218.2218

Published: 2014

Journal Articles

Loss of IKKβ Increases the Number and Self-Renewal Capacity of Hematopoietic Stem Cells

Jing Zhang, PhD, Li Li, PhD, Albert S. Baldwin, PhD, Alan D. Friedman, MD, Ido Paz-Priel, MD

Blood (2014) 124 (21): 4345.

https://doi.org/10.1182/blood.V124.21.4345.4345

Published: 2014

Journal Articles

Phosphorylation of RUNX1 by Cyclin-Dependent Kinase Reduces Direct Interaction with HDAC1 and HDAC3 and Stimulates Marrow Progenitor Proliferation.

Hong Guo, M.D., Ph.D., Alan D. Friedman, MD

Blood (2009) 114 (22): 2508.

https://doi.org/10.1182/blood.V114.22.2508.2508

Published: 2009

Journal Articles

C/EBPα or Its Leukemic Mutants Directly Activate nfkb1 Transcription and Displace HDAC1 or HDAC3 From Chromatin-Associated NF-κB p50 to Induce Anti-Apoptotic Genes.

Ido Paz-Priel, MD, Alan D. Friedman, MD

Blood (2009) 114 (22): 76.

https://doi.org/10.1182/blood.V114.22.76.76

Published: 2009

Journal Articles

C/Ebpβ Inhibits Apoptosis in Hematopoietic Cells Via Interaction with NF-κb p50.

Rebecca McFall, MD, Ido Paz-Priel, MD, Alan D. Friedman, MD

Blood (2008) 112 (11): 1332.

https://doi.org/10.1182/blood.V112.11.1332.1332

Published: 2008

Journal Articles

Cyclin-Dependent Kinase Phosphorylation of RUNX1/AML1 on Three Sites Increases Trans-Activation Potency and Stimulates Cell Proliferation.

Alan D. Friedman, MD, Linsheng Zhang, M.D., Ph.D., Florence Bernardin Fried, Ph.D.

Blood (2007) 110 (11): 3351.

https://doi.org/10.1182/blood.V110.11.3351.3351

Published: 2007

Journal Articles

C/EBPα:AP-1 Leucine Zipper Heterodimers Bind Novel DNA Elements, Activate the PU.1 Promoter, and Direct Monocyte Lineage Commitment More Potently Than C/EBPα Homodimers or AP-1.

Alan D. Friedman, MD, Dong Hong Cai, M.D., Ph.D., Dehua Wang, M.D., M.Sc., Jeffrey Keefer, M.D., Ph.D., Christine Yeamans, M.D., Kortney Hensley

Blood (2007) 110 (11): 1232.

https://doi.org/10.1182/blood.V110.11.1232.1232

Published: 2007

Journal Articles

Heterodimers Formed Via Leucine Zipper Interaction between C/EBPα and c-Jun or c-Fos Induce Monocytic Lineage Commitment.

Dong Hong Cai, PhD, Dehua Wang, MD, MS, Jeffrey R. Keefer, MD, Kortney Hensley, Alan D. Friedman, MD

Blood (2006) 108 (11): 1170.

https://doi.org/10.1182/blood.V108.11.1170.1170

Published: 2006

Journal Articles

C/EBPα Binds and Activates the Distal PU.1 Enhancer.

Christine Yeamans, MD, Dehua Wang, MD, MS, Ido Paz-Priel, MD, Daniel G. Tenen, MD, Alan D. Friedman, MD

Blood (2006) 108 (11): 1176.

https://doi.org/10.1182/blood.V108.11.1176.1176

Published: 2006

NARROW

Pathways Relevant to AML Pathogenesis Targeting the Hematopoietic-Specific Cebpa +37 Kb Enhancer

The Roles of RUNX1 in Human Hematopoiesis and Megakaryopoiesis Revealed By Genome-Targeted Human iPSCs and an Improved Hematopoietic Differentiation Model

In Vivo Deletion of the Cebpa +37 Kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis

The Multimerization Domain of Cbfß-SMMHC Is Required for Leukemogenesis

Functional Dissection of the C Terminus of CBFβ-SMMHC Indicates a Critical Role of the Multimerization Domain during Hematopoiesis and Leukemogenesis

Loss of IKKβ Increases the Number and Self-Renewal Capacity of Hematopoietic Stem Cells

Phosphorylation of RUNX1 by Cyclin-Dependent Kinase Reduces Direct Interaction with HDAC1 and HDAC3 and Stimulates Marrow Progenitor Proliferation.

C/EBPα or Its Leukemic Mutants Directly Activate nfkb1 Transcription and Displace HDAC1 or HDAC3 From Chromatin-Associated NF-κB p50 to Induce Anti-Apoptotic Genes.

C/Ebpβ Inhibits Apoptosis in Hematopoietic Cells Via Interaction with NF-κb p50.

Cyclin-Dependent Kinase Phosphorylation of RUNX1/AML1 on Three Sites Increases Trans-Activation Potency and Stimulates Cell Proliferation.

C/EBPα:AP-1 Leucine Zipper Heterodimers Bind Novel DNA Elements, Activate the PU.1 Promoter, and Direct Monocyte Lineage Commitment More Potently Than C/EBPα Homodimers or AP-1.

Heterodimers Formed Via Leucine Zipper Interaction between C/EBPα and c-Jun or c-Fos Induce Monocytic Lineage Commitment.

C/EBPα Binds and Activates the Distal PU.1 Enhancer.

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ASH Publications

American Society of Hematology

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ASH Publications

American Society of Hematology

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