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Journal Articles

The Efficacy of the FLT3 Inhibitor Lestaurtinib in AML Depends on Adequate Plasma Inhibitory Activity (PIA), and Is Unaffected by Rising FLT Ligand Levels: An Update of the NCRI AML15 & 17 Trials

Steven Knapper, DM MRCP FRCPath, Paul White, PhD, Mark J. Levis, MD, PhD, Robert K Hills, MA, MSc, DPhil, Nigel H. Russell, MD, Alan Burnett, MD, ChB, FRCP, FRCPath, FMedSci

Blood (2011) 118 (21): 421.

https://doi.org/10.1182/blood.V118.21.421.421

Published: 2011

Journal Articles

Distinct Regulation of β- and γ-Catenin throughout Hematopoietic Development Contrasts with Their Cooperative Roles In Acute Myeloid Leukemia.

Rhys Gareth Morgan, BSc, Lorna Pearn, Kate Liddiard, PhD, Robert Hills, MA, MSc, DPhil, Alan Burnett, MD, Alex Tonks, PhD, Richard L Darley, PhD

Blood (2010) 116 (21): 1573.

https://doi.org/10.1182/blood.V116.21.1573.1573

Published: 2010

Journal Articles

Over-Expression of CD200 In Acute Myeloid Leukemia Mediates the Expansion of Regulatory T-Lymphocytes and Directly Inhibits Natural Killer Cell Tumor Immunity

Steven J Coles, PhD, Stephen Man, PhD, Robert Hills, MA, MSc, DPhil, Eddie CY Wang, PhD, Alan Burnett, MD, Richard L Darley, PhD, Alex Tonks, PhD

Blood (2010) 116 (21): 491.

https://doi.org/10.1182/blood.V116.21.491.491

Published: 2010

Journal Articles

PDK1 Overexpression In Acute Myeloid Leukemia; Clinical Significance and Potential as a Therapeutic Target

Joanna Zabkiewicz, PhD, Lorna Pearn, Robert Hills, MA, MSc, DPhil, Rhys, Gareth Morgan, BSc, Alan Burnett, MD, Alex Tonks, PhD, Richard L Darley, PhD

Blood (2010) 116 (21): 2162.

https://doi.org/10.1182/blood.V116.21.2162.2162

Published: 2010

Journal Articles

Ras Promotes Production of Reactive Oxygen Species in Normal Human CD34 + Cells: Role in Promoting Cell Survival and Protein Phosphorylation

Paul S Hole, BA, Lorna Pearn, Philip E James, PhD, Alan Burnett, MD, Richard L Darley, PhD, Alex Tonks, PhD

Blood (2008) 112 (11): 3797.

https://doi.org/10.1182/blood.V112.11.3797.3797

Published: 2008

Journal Articles

A Phase I Study of CHR-2797, an Orally Active Aminopeptidase Inhibitor in Elderly and/or Treatment Refractory Patients with Acute Myeloid Leukemia or Multiple Myeloma.

Faith Davies, MD, Gert Ossenkoppele, MD, Pierre Zachee, MD, Richard Noppeney, MD, Alan Burnett, MD, Michel Delforge, MD, Pieter Sonneveld, MD, Gareth Morgan, MD, Sonja Zweegman, MD, Dimitri Breems, MD, Alison Richardson, PhD, Leon Hooftman, MD, Bob Lowenberg, MD

Blood (2007) 110 (11): 443.

https://doi.org/10.1182/blood.V110.11.443.443

Published: 2007

Journal Articles

Minimal Residual Disease Monitoring by RQ-PCR in Core Binding Factor Positive AML Allows Risk-Stratification and Predicts Relapse: Results of the UK MRC AML-15 Trial.

John Ahman Liu-Yin, FRCP, Sarah B. Daly, PhD, Michelle A. Sale, MSc, Stuart Green, MSc, Khalid Tobal, PhD, Robert Hills, DPhil, Alan Burnett, MD

Blood (2007) 110 (11): 543.

https://doi.org/10.1182/blood.V110.11.543.543

Published: 2007

Journal Articles

Competing Influences of Genetic and Leukaemia-Specific Factors on P-Glycoprotein Expression in Blasts from 817 Patients Entered into the NCRN AML14 and 15 Trials.

Claire H. Seedhouse, PhD, Martin Grundy, BSc, Paul White, PhD, Yun Li, MSc, Janet Fisher, BSc, Darya Yakunina, MD, Anthony Moorman, PhD, Nigel Russell, MD, Alan Burnett, MD, Monica Pallis, PhD

Blood (2006) 108 (11): 835.

https://doi.org/10.1182/blood.V108.11.835.835

Published: 2006

Journal Articles

RUNX1-RUNX1T1 Induces Over-Expression of γ-Catenin in Human CD34 + Cells, Increasing Self Renewal and Impairing Granulocytic Differentiation.

Alex Tonks, PhD, Lorna Pearn, Megan Musson, Amanda Gilkes, Ken Mills, PhD, Alan Burnett, MD, Richard Darley, PhD

Blood (2005) 106 (11): 3003.

https://doi.org/10.1182/blood.V106.11.3003.3003

Published: 2005

Journal Articles

P-Glycoprotein Overexpresion and Internal Tandem Duplications of FLT3 Are Characteristic of Discrete Populations of Elderly AML Patients.

Monica Pallis, PhD, Louise Truran, B Sc, Martin Grundy, B Sc, Janet Fisher, M Sc, Robert Hills, PhD, Keith Wheatley, PhD, Nigel Russell, MD, Alan Burnett, MD

Blood (2004) 104 (11): 196.

https://doi.org/10.1182/blood.V104.11.196.196

Published: 2004

NARROW

The Efficacy of the FLT3 Inhibitor Lestaurtinib in AML Depends on Adequate Plasma Inhibitory Activity (PIA), and Is Unaffected by Rising FLT Ligand Levels: An Update of the NCRI AML15 & 17 Trials

Distinct Regulation of β- and γ-Catenin throughout Hematopoietic Development Contrasts with Their Cooperative Roles In Acute Myeloid Leukemia.

Over-Expression of CD200 In Acute Myeloid Leukemia Mediates the Expansion of Regulatory T-Lymphocytes and Directly Inhibits Natural Killer Cell Tumor Immunity

PDK1 Overexpression In Acute Myeloid Leukemia; Clinical Significance and Potential as a Therapeutic Target

Ras Promotes Production of Reactive Oxygen Species in Normal Human CD34 + Cells: Role in Promoting Cell Survival and Protein Phosphorylation

A Phase I Study of CHR-2797, an Orally Active Aminopeptidase Inhibitor in Elderly and/or Treatment Refractory Patients with Acute Myeloid Leukemia or Multiple Myeloma.

Minimal Residual Disease Monitoring by RQ-PCR in Core Binding Factor Positive AML Allows Risk-Stratification and Predicts Relapse: Results of the UK MRC AML-15 Trial.

Competing Influences of Genetic and Leukaemia-Specific Factors on P-Glycoprotein Expression in Blasts from 817 Patients Entered into the NCRN AML14 and 15 Trials.

RUNX1-RUNX1T1 Induces Over-Expression of γ-Catenin in Human CD34 + Cells, Increasing Self Renewal and Impairing Granulocytic Differentiation.

P-Glycoprotein Overexpresion and Internal Tandem Duplications of FLT3 Are Characteristic of Discrete Populations of Elderly AML Patients.

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American Society of Hematology

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American Society of Hematology

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