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Journal Articles

Expression of Vav1-Myo1F Fusion Affects T-Cell Differentiation and Induces T-Cell Lymphoma

Jose Rodriguez Cortes, PhD, Robert Albero Gallego, PhD, Ioan Filip, PhD, Juan Angel Patino, PhD, Anisha Cooke, Wen-Hsuan Lin, Anouchka P Laurent, Bobby B Shih, Aidan Quinn, Raul Rabadan, PhD, Adolfo A. Ferrando, MD PhD, Teresa Palomero, PhD

Blood (2020) 136 (Supplement 1): 4.

https://doi.org/10.1182/blood-2020-136081

Published: 2020

Journal Articles

The Central Role of MAPK-ERK Signaling in IL7-Dependent and IL7-Independent Steroid Resistance Reveals a Broad Application of MEK-Inhibitors Compared to JAK1/2-Inhibition in T-ALL

Jordy C.G. Van Der Zwet, MD, Jessica G.C.A.M. Buijs-Gladdines, Valentina Cordo', MSc, Donna Debets, MSc, Willem K. Smits, Zhongli Chen, MSc, Jelle Dylus, Guido Zaman, PhD, Maarten Altelaar, PhD, Koichi Oshima, MD PhD, Beat Bornhauser, Jean-Pierre Bourquin, MD PhD, Jan Cools, PhD, Adolfo A. Ferrando, MD PhD, Josef Vormoor, MD PhD, Rob Pieters, MDPhDMSc, Britta Julia Vormoor, MD, Jules P.P. Meijerink, PhD

Blood (2020) 136 (Supplement 1): 20.

https://doi.org/10.1182/blood-2020-139305

Published: 2020

Journal Articles

Role of Vav1 Genomic Alterations in T-Cell Differentiation and Transformation in Peripheral T-Cell Lymphoma

Jose Rodriguez Cortes, PhD, Anisha R. Cooke, Aidan Quinn, Ioan Filip, PhD, Juan Angel Patino, PhD, Raul Rabadan, PhD, Adolfo A. Ferrando, MD PhD, Teresa Palomero, PhD

Blood (2019) 134 (Supplement_1): 1482.

https://doi.org/10.1182/blood-2019-129438

Published: 2019

Journal Articles

Glutaminase Inhibition Overcomes Acquired Resistance to Mitochondrial Complex I in NOTCH1-Driven T-Cell Acute Lymphoblastic Leukemias (T-ALL) Via Block of Glutamine Driven Reductive Metabolism

Blood (2019) 134 (Supplement_1): 806.

https://doi.org/10.1182/blood-2019-128930

Published: 2019

Journal Articles

Mitochondrial Complex I Inhibitor Iacs-010759 Reverses the NOTCH1-Driven Metabolic Reprogramming in T-ALL Via Blockade of Oxidative Phosphorylation: Synergy with Chemotherapy and Glutaminase Inhibition

Blood (2018) 132 (Supplement 1): 4020.

https://doi.org/10.1182/blood-2018-99-117310

Published: 2018

Journal Articles

Role of Rhoa G17V in Cell Migration and Transformation in Angioimmunoblastic T-Cell Lymphoma

Teresa Palomero, PhD, Jose R. Cortes, PhD, Anisha R. Cooke, Laura Belver, PhD, Govind Bhagat, Adolfo A. Ferrando, MD PhD

Blood (2018) 132 (Supplement 1): 4122.

https://doi.org/10.1182/blood-2018-99-115005

Published: 2018

Journal Articles

Suppression of GATA3 Binding Drives Selective Abrogation of NOTCH1-MYC Enhancer Activity By Nucleosome Invasion in Thymocyte Development and Leukemia

Laura Belver, PhD, Alexander Y Yang, Daniel Herranz, PharmD, Aidan Quinn, Francesco G Brundu, PhD, Pablo Perez-Duran, PhD, Silvia Alvarez, PhD, Devya Gurung, Pedro P Rocha, PhD, Ramya Raviram, PhD, Marissa Rashkovan, PhD, Raul Rabadan, PhD, Adolfo A. Ferrando, MD PhD

Blood (2018) 132 (Supplement 1): 545.

https://doi.org/10.1182/blood-2018-99-119423

Published: 2018

Journal Articles

Clonal Evolution Mechanisms and Collateral Sensitivity to Impdh Inhibitor Therapy in Relapsed Lymphoblastic Leukemia

Chelsea Dieck, Gannie Tzoneva, PhD, Koichi Oshima, MD PhD, Alberto Ambesi-Impiombato, Marta Sanchez-Martin, PhD, Maria Luisa Sulis, MD, Motohiro Kato, MD PhD, Katsuyoshi Koh, MD, Maddalena Paganin, PhD, Giuseppe Basso, MD, Julie M. Gastier-Foster, PhD, Mignon L. Loh, MD, Renate Kirschner-Schwabe, PhD, Chioma Madubata, Raul Rabadan, Adolfo A. Ferrando, MD PhD

Blood (2017) 130 (Supplement 1): 2602.

https://doi.org/10.1182/blood.V130.Suppl_1.2602.2602

Published: 2017

Journal Articles

Lineage Deconvolution Using Chromatin Accessibility and DNA Methylation Shows a Spectrum of Lineage Characteristics and Differentiation States across Acute Leukemias

Jacob L Glass, MDPhD, Alyson J Palia, Francine E. Garrett-Bakelman, MDPhD, Richard Koche, PhD, Ross L. Levine, MD, Martin S. Tallman, MD, Richard James Dillon, MA, PhD MRCP, FRCPath, David Grimwade, Adolfo A. Ferrando, MD PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Maria E. Figueroa, MD, Ari Melnick, MD, Olivier Elemento, PhD

Blood (2017) 130 (Supplement 1): 1208.

https://doi.org/10.1182/blood.V130.Suppl_1.1208.1208

Published: 2017

Journal Articles

Direct Pharmacological Inhibition of the Transcription Factor PU.1 in Acute Myeloid Leukemia

Blood (2017) 130 (Supplement 1): 858.

https://doi.org/10.1182/blood.V130.Suppl_1.858.858

Published: 2017

Journal Articles

Mechanisms of NT5C2 mutations Driving Thiopurine Resistance in Acute Lymphoblastic Leukemia

Chelsea Dieck, Gannie Tzoneva, PhD, Farhad Forouhar, Zachary Carpenter, PhD, Alberto Ambesi-Impiombato, Marta Sanchez-Martin, PhD, Liang Tong, Adolfo A. Ferrando, MD PhD

Blood (2017) 130 (Supplement 1): 715.

https://doi.org/10.1182/blood.V130.Suppl_1.715.715

Published: 2017

Journal Articles

Mutational Landscape, Clonal Evolution Patterns and Role of RAS Mutations in Relapsed Acute Lymphoblastic Leukemia

Blood (2016) 128 (22): 4068.

https://doi.org/10.1182/blood.V128.22.4068.4068

Published: 2016

Journal Articles

Mitochondrial Complex I Inhibition with Iacs-010759 in T-ALL Preclinical Models

Natalia Baran, PhD, Jennifer Molina, PhD, Antonio Cavazos, MS, Karine Harutyunyan, PhD, Ningping Feng, PhD, Jason Gay, MS, Sujan Piya, PhD, Sriram Shanmuga Velandy, MS, Elias J. Jabbour, MD, Michael Andreeff, MD PhD, Stefano Tiziani, PhD, Adolfo A. Ferrando, MD PhD, Patrick Zweidler-McKay, MD PhD, M. Emilia Di Francesco, PhD, Joseph R. Marszalek, PhD, Marina Konopleva, MD PhD

Blood (2016) 128 (22): 4028.

https://doi.org/10.1182/blood.V128.22.4028.4028

Published: 2016

Journal Articles

VAV1 Activating Mutations and Translocations in Peripheral T-Cell Lymphomas

Blood (2016) 128 (22): 2741.

https://doi.org/10.1182/blood.V128.22.2741.2741

Published: 2016

Journal Articles

Role and Mechanisms of Rhoa G17V in the Pathogenesis of AITL

Jose R Cortes, PhD, Alberto Ambesi-Impiombato, MD PhD, Lucile Couronne, Christine S Kim, Zachary West, Laura Belver, PhD, Ana Carolina da Silva Almeida, PhD, Govind Bhagat, MD MBBS, Olivier A. Bernard, PhD, Adolfo A. Ferrando, MD PhD, Teresa Palomero, PhD

Blood (2016) 128 (22): 608.

https://doi.org/10.1182/blood.V128.22.608.608

Published: 2016

Journal Articles

Leukemia-Specific Delivery of Mutant NOTCH1 Targeted Therapy

Giovanni Roti, MD PhD, Jun Qi, PhD, Samuel Kitara, Anthony C. Varca, Marta Sanchez-Martin, PhD, Andrew L. Kung, MD PhD, Adolfo A. Ferrando, MD PhD, James E. Bradner, MD, Kimberly Stegmaier, MD

Blood (2016) 128 (22): 889.

https://doi.org/10.1182/blood.V128.22.889.889

Published: 2016

Journal Articles

The Mutational Landscape of CTCL and Sezary Syndrome

Teresa Palomero, PhD, Ana Carolina da Silva Almeida, PhD, Francesco Abate, PhD, Hossein Khiabanian, PhD, Estela Martinez-Escala, MD, Joan Guitart, MD, Cornelis P Tensen, MD, Maarten H. Vermeer, MD PhD, Raul Rabadan, PhD, Adolfo A. Ferrando, MD PhD

Blood (2015) 126 (23): 573.

https://doi.org/10.1182/blood.V126.23.573.573

Published: 2015

Journal Articles

Synergistic Targeting of Protein Translation and Inhibition of NOTCH Signaling in T-ALL

Marta Sanchez-Martin, PhD, Alberto Ambesi-Impiombato, MDPhD, Luyao Xu, Yue Qin, Daniel Herranz, PhD, Mukesh Bansal, PhD, Tiziana Girardi, Kim De Keersmaecker, Andrea Califano, PhD, Adolfo A. Ferrando, MD PhD

Blood (2015) 126 (23): 3719.

https://doi.org/10.1182/blood.V126.23.3719.3719

Published: 2015

Journal Articles

De Novo Purine Biosynthesis in Drug Resistance and Tumor Relapse of Childhood ALL

Hui Li, PhD, Benshang Li, Fan Yang, Caiwen Duan, Yun Bai, Jun J Yang, PhD, Jing Chen, MD PhD, Arend von Stackelberg, MD, Hongzhuan Chen, PhD, JingYan Tang, MD, Adolfo A. Ferrando, MD PhD, Jinghui Zhang, PhD, Shengyue Wang, Renate Kirschner-Schwabe, PhD, Bin-Bing S. Zhou, PhD

Blood (2015) 126 (23): 2627.

https://doi.org/10.1182/blood.V126.23.2627.2627

Published: 2015

Journal Articles

The Sub-Clonal Complexity of STIL-TAL1 T-ALL

Caroline L Furness, MD, Marcela B Mansur, PhD, Victoria J Weston, PhD, Sarah Jenkinson, MSc, Frederik W van Delft, MDPhD, Lyndal Kearney, PhD, Ian Titley, PhD, Anthony M Ford, PhD, Rosemary E Gale, Pamela R Kearns, MBChB, PhD FRCPCH, Adolfo A. Ferrando, MD PhD, Christine J. Harrison, Nicola E Potter, PhD, Mel Greaves, FRS

Blood (2014) 124 (21): 3788.

https://doi.org/10.1182/blood.V124.21.3788.3788

Published: 2014

NARROW

Expression of Vav1-Myo1F Fusion Affects T-Cell Differentiation and Induces T-Cell Lymphoma

The Central Role of MAPK-ERK Signaling in IL7-Dependent and IL7-Independent Steroid Resistance Reveals a Broad Application of MEK-Inhibitors Compared to JAK1/2-Inhibition in T-ALL

Role of Vav1 Genomic Alterations in T-Cell Differentiation and Transformation in Peripheral T-Cell Lymphoma

Glutaminase Inhibition Overcomes Acquired Resistance to Mitochondrial Complex I in NOTCH1-Driven T-Cell Acute Lymphoblastic Leukemias (T-ALL) Via Block of Glutamine Driven Reductive Metabolism

Mitochondrial Complex I Inhibitor Iacs-010759 Reverses the NOTCH1-Driven Metabolic Reprogramming in T-ALL Via Blockade of Oxidative Phosphorylation: Synergy with Chemotherapy and Glutaminase Inhibition

Role of Rhoa G17V in Cell Migration and Transformation in Angioimmunoblastic T-Cell Lymphoma

Suppression of GATA3 Binding Drives Selective Abrogation of NOTCH1-MYC Enhancer Activity By Nucleosome Invasion in Thymocyte Development and Leukemia

Clonal Evolution Mechanisms and Collateral Sensitivity to Impdh Inhibitor Therapy in Relapsed Lymphoblastic Leukemia

Lineage Deconvolution Using Chromatin Accessibility and DNA Methylation Shows a Spectrum of Lineage Characteristics and Differentiation States across Acute Leukemias

Direct Pharmacological Inhibition of the Transcription Factor PU.1 in Acute Myeloid Leukemia

Mechanisms of NT5C2 mutations Driving Thiopurine Resistance in Acute Lymphoblastic Leukemia

Mutational Landscape, Clonal Evolution Patterns and Role of RAS Mutations in Relapsed Acute Lymphoblastic Leukemia

Mitochondrial Complex I Inhibition with Iacs-010759 in T-ALL Preclinical Models

VAV1 Activating Mutations and Translocations in Peripheral T-Cell Lymphomas

Role and Mechanisms of Rhoa G17V in the Pathogenesis of AITL

Leukemia-Specific Delivery of Mutant NOTCH1 Targeted Therapy

The Mutational Landscape of CTCL and Sezary Syndrome

Synergistic Targeting of Protein Translation and Inhibition of NOTCH Signaling in T-ALL

De Novo Purine Biosynthesis in Drug Resistance and Tumor Relapse of Childhood ALL

The Sub-Clonal Complexity of STIL-TAL1 T-ALL

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American Society of Hematology

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American Society of Hematology

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