Topics:
cell nucleus, centromere

In the article by Alcobia et al entitled “Spatial associations of centromeres in the nuclei of hematopoietic cells: evidence for cell-type-specific organizational patterns,” which appeared in the March 1, 2000, issue of Blood (95:1608-1615), some headings in Table 1 were incorrect. Following is a corrected version of the table.

Table 1.

Frequencies of association of specific centromeres in quiescent human peripheral blood cells

Centromeres PBLCentromeres PBM a PBG a
A/B B/C A/CA/B/C n-a
1/2/3  0.18  0.16 ± 0.01  0.23 0.01  0.56  1/4  0.38* 0.47* 
2/3/4 0.16 ± 0.01  0.18  0.20 ± 0.04  0.01  0.61 3/4  0.24  0.24  
3/4/6  0.15  0.20 0.15 ± 0.02  0  0.55  3/6  0.23  0.30* 
6/7/8 0.26  0.29 ± 0.06  0.22  0.05  0.49  4/6 0.21  0.16  
7/8/9  0.29 ± 0.06  0.38 0.43 ± 0.03  0.08  0.23  7/9  0.36  ND 
9/10/11  0.24  0.42  0.35  0.05  0.34  10/11 0.26* 0.24* 
10/11/12  0.42  0.37  0.26  0.06 0.29  11/12  0.22*,† 0.52*,† 
12/15/16  0.24 0.46 ± 0.02  0.20  0.05  0.21  13/21  0.82* 0.70  
15/16/17  0.46 ± 0.02  0.25 ± 0.02 0.35 ± 0.03  0.07  0.24  14/22  0.79  ND 
17/18/20  0.34  0.41  0.21  0.07  0.22  15/16 0.44  0.34  
20/X/Y  0.22  0.13  0.09  0.01 0.60  18/20  0.56* ND  
Y/1/2  0.16  0.19 0.10  0  0.57  
5/19  0.23     0.77 
13/21  0.64     0.36  
14/22  0.69    0.31  
1/4  0.19     0.81  
2/6 0.18     0.82  
7/11  0.30    0.70 
Centromeres PBLCentromeres PBM a PBG a
A/B B/C A/CA/B/C n-a
1/2/3  0.18  0.16 ± 0.01  0.23 0.01  0.56  1/4  0.38* 0.47* 
2/3/4 0.16 ± 0.01  0.18  0.20 ± 0.04  0.01  0.61 3/4  0.24  0.24  
3/4/6  0.15  0.20 0.15 ± 0.02  0  0.55  3/6  0.23  0.30* 
6/7/8 0.26  0.29 ± 0.06  0.22  0.05  0.49  4/6 0.21  0.16  
7/8/9  0.29 ± 0.06  0.38 0.43 ± 0.03  0.08  0.23  7/9  0.36  ND 
9/10/11  0.24  0.42  0.35  0.05  0.34  10/11 0.26* 0.24* 
10/11/12  0.42  0.37  0.26  0.06 0.29  11/12  0.22*,† 0.52*,† 
12/15/16  0.24 0.46 ± 0.02  0.20  0.05  0.21  13/21  0.82* 0.70  
15/16/17  0.46 ± 0.02  0.25 ± 0.02 0.35 ± 0.03  0.07  0.24  14/22  0.79  ND 
17/18/20  0.34  0.41  0.21  0.07  0.22  15/16 0.44  0.34  
20/X/Y  0.22  0.13  0.09  0.01 0.60  18/20  0.56* ND  
Y/1/2  0.16  0.19 0.10  0  0.57  
5/19  0.23     0.77 
13/21  0.64     0.36  
14/22  0.69    0.31  
1/4  0.19     0.81  
2/6 0.18     0.82  
7/11  0.30    0.70 

PBL, peripheral blood lymphocytes; PBM, peripheral blood monocytes; PBG, peripheral blood granulocytes; A-B-C, triad of centromeres analyzed. A/B, B/C, A/C, A/B/C, respectively, associations between the first and the second centromere of the triad, the second and the third, the first and the third, and all three. Association between homologous centromeres is not indicated (see text). a, associated; n-a, nonassociated; ND, not done.

*

Comparison with lymphocytes, P < .05.

†

Comparison between monocytes and granulocytes, P < .05.

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Copyright © 2000 The American Society of Hematology
2000
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