We show that adrenergic agents modulate hematopoietic reconstitution after syngeneic bone marrow transplantation (BMT) in mice. Chemical sympathectomy by 6-hydroxydopamine (6-OHDA) significantly increased the number of peripheral blood leukocytes after syngeneic BMT. The alpha 1- adrenergic antagonist prazosin mimicked and extended the effect of 6- OHDA, with an additional rapid and significant increase of platelets, marrow granulocyte-macrophage colony-forming units, and nucleated spleen cells. Differential leukocyte counts and spleen histology from prazosin-treated mice confirmed that myelopoiesis was greatly enhanced and accelerated. In contrast, the beta-adrenergic blocker propranolol abolished the prazosin-induced increase of platelets. The detailed mechanisms by which prazosin exerts these interesting effects remain to be elucidated.

Topics:
adrenergic agents, bone marrow transplantation, mice, hematopoiesis, prazosin, oxidopamine, adrenergic antagonists, beta-blockers, propranolol, sympathectomy, chemical
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Copyright © 1992 by The American Society of Hematology
1992
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