Abstract
In an open prospective, multicenter study enrolling 48 selected patients with chronic immune thrombocytopenia who achieved complete response for 1 year on thrombopoietin receptor agonists, half of the patients maintained a sustained response off treatment 4 years after treatment discontinuation.
References
1.
Wang
L
, Gao
Z
, Chen
XP
, et al. Efficacy and safety of thrombopoietin receptor agonists in patients with primary immune thrombocytopenia: a systematic review and meta-analysis
. Sci Rep
. 2016
;6
:39003
.2.
Ghanima
W
, Cooper
N
, Rodeghiero
F
, Godeau
B
, Bussel
JB
. Thrombopoietin receptor agonists: ten years later
. Haematologica
. 2019
;104
(6
):1112
-1123
.3.
Ghadaki
B
, Nazi
I
, Kelton
JG
, Arnold
DM
. Sustained remissions of immune thrombocytopenia associated with the use of thrombopoietin receptor agonists
. Transfusion (Paris)
. 2013
;53
(11
):2807
-2812
.4.
Mahévas
M
, Fain
O
, Ebbo
M
, et al. The temporary use of thrombopoietin-receptor agonists may induce a prolonged remission in adult chronic immune thrombocytopenia. Results of a French observational study
. Br J Haematol
. 2014
;165
(6
):865
-869
.5.
Červinek
L
, Mayer
J
, Doubek
M
. Sustained remission of chronic immune thrombocytopenia after discontinuation of treatment with thrombopoietin-receptor agonists in adults
. Int J Hematol
. 2015
;102
(1
):7
-11
.6.
González-López
TJ
, Pascual
C
, Álvarez-Román
MT
, et al. Successful discontinuation of eltrombopag after complete remission in patients with primary immune thrombocytopenia
. Am J Hematol
. 2015
;90
(3
):E40
-E43
.7.
Newland
A
, Godeau
B
, Priego
V
, et al. Remission and platelet responses with romiplostim in primary immune thrombocytopenia: final results from a phase 2 study
. Br J Haematol
. 2016
;172
(2
):262
-273
.8.
Lucchini
E
, Palandri
F
, Volpetti
S
, et al; for Gruppo Italiano Malattie Ematologiche dell’Adulto GIMEMA
. Eltrombopag second-line therapy in adult patients with primary immune thrombocytopenia in an attempt to achieve sustained remission off-treatment: results of a phase II, multicentre, prospective study
. Br J Haematol
. 2021
;193
(2
):386
-396
.9.
Kapur
R
, Aslam
R
, Speck
ER
, Rebetz
JM
, Semple
JW
. Thrombopoietin receptor agonist (TPO-RA) treatment raises platelet counts and reduces anti-platelet antibody levels in mice with immune thrombocytopenia (ITP)
. Platelets
. 2020
;31
(3
):399
-402
.10.
Bao
W
, Bussel
JB
, Heck
S
, et al. Improved regulatory T-cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents
. Blood
. 2010
;116
(22
):4639
-4645
.11.
Guillet
S
, Crickx
E
, Azzaoui
I
, et al. Prolonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study
. Blood
. 2023
;141
(23
):2867
-2877
.12.
Carpenedo
M
, Cantoni
S
, Coccini
V
, Fedele
M
, Morra
E
, Pogliani
EM
. Feasibility of romiplostim discontinuation in adult thrombopoietin-receptor agonist responsive patients with primary immune thrombocytopenia: an observational retrospective report in real life clinical practice
. Hematol Rep
. 2015
;7
(1
):5673
.13.
Zufferey
A
, Speck
ER
, Machlus
KR
, et al. Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets
. Blood Adv
. 2017
;1
(20
):1773
-1785
.© 2025 American Society of Hematology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
2025
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