Anemia is a common consequence of myelofibrosis. The treatment of myelofibrosis-associated anemia is complicated by a multifactorial pathobiology and a lack of therapies that result in normalization of the bone marrow and complete restoration of its function. Established agents that are used to treat anemia in other bone marrow failure states, such as myelodysplastic syndromes and aplastic anemia, are used for the treatment of myelofibrosis-associated anemia. However, there has been rapid development of new anemia-directed therapies, some of which have garnered regulatory approval. In addition to adopting therapies from other disease states, better understating of the root causes of myelofibrosis-associated anemia has positioned the field to be on the cutting edge of new anemia treatments, spearheading the advancement of agents that work on the hepcidin pathway to improve red cell production.
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Myeloproliferative Neoplasms|
April 17, 2025
How I treat anemia in myelofibrosis
Akriti G. Jain,
Akriti G. Jain
1Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
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Aaron T. Gerds
Aaron T. Gerds
1Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
2Clinical Research Office, Case Comprehensive Cancer Center, Cleveland, OH
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Blood (2025) 145 (16): 1738–1746.
Article history
Submitted:
August 19, 2024
Accepted:
January 8, 2025
First Edition:
January 14, 2025
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Citation
Akriti G. Jain, Aaron T. Gerds; How I treat anemia in myelofibrosis. Blood 2025; 145 (16): 1738–1746. doi: https://doi.org/10.1182/blood.2023022414
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