Page 663: In Figure 2A, due to an error in figure assembly, the representative plot of a knockout (KO) mouse on the right is a duplicate of the plot of a heterozygous (HET) mouse (middle plot), and the plots represent the total splenic lymphocytes stained for B220 and the germinal-center (GC) marker peanut agglutinin (PNA), while the percentages in the plots indicate the percentages of PNA+ cells within the B220+ population, as also shown in Figure 2B. A corrected Figure 2A is shown below and displays, for each genotype, the strategy used to identify GC B cells by PNA staining upon gating for B220+ cells. The percentages of GC B cells identified with this strategy are reported in Figure 2B of the original article for all mice in the cohort. This error does not affect the conclusions of the study.
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Figure 2
FBXO11 deletion leads to an increase in GC B cells and affects the DZ/LZ ratio. (A) Flow cytometry analysis of splenic mononuclear cells from age-matched FBXO11+/+-Cγ1cretg/+ (WT), FBXO11fl/+-Cγ1cretg/+ (HET), and FBXO11fl/fl-Cγ1cretg/+ (KO) for lectin PNA and the B-cell marker B220. Mice were immunized with SRBCs 10 days prior to the analysis.
Figure 2
FBXO11 deletion leads to an increase in GC B cells and affects the DZ/LZ ratio. (A) Flow cytometry analysis of splenic mononuclear cells from age-matched FBXO11+/+-Cγ1cretg/+ (WT), FBXO11fl/+-Cγ1cretg/+ (HET), and FBXO11fl/fl-Cγ1cretg/+ (KO) for lectin PNA and the B-cell marker B220. Mice were immunized with SRBCs 10 days prior to the analysis.
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