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Lymphoid Neoplasia
TO THE EDITOR:
Fibrin-associated large B-cell lymphoma (FA-LBCL) is a microscopic proliferation of large B cells arising in association with fibrinous debris in specific anatomic locations, including cardiac valves and myxomas, preexisting cysts or pseudocysts, and chronic hematomas or thrombi.1,2 Some of these locations are associated with the presence of foreign bodies, especially artificial cardiac valves and endovascular grafts, whereas others arise in the context of native tissue.
The pathophysiology of FA-LBCL is largely unknown; however, a few potential pathogenic mechanisms have been proposed. The lymphoma cells in most cases are positive for Epstein-Barr virus (EBV) and express EBV latent membrane proteins and EBV nuclear antigens (type III latency), which is unusual for lymphoma in immunocompetent patients because of the immunogenicity of these viral proteins. This has led to the hypothesis that the lymphoma cells are obliged to...
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.© 2023 by The American Society of Hematology
2023
© 2023 by The American Society of Hematology
2023
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