The gene expression programs that establish and maintain specific cell states in humans are controlled by thousands of transcription factors, cofactors, and chromatin regulators. Our understanding of the DNA elements and regulators that control gene expression programs has advanced considerably in the last year. I will describe new insights into the roles that these elements and regulators play in global gene control during normal development and in various diseases. These insights provide opportunities for the development of novel diagnostics and therapeutics.

Disclosures:

Young:Syros Pharmaceuticals: Consultancy, Equity Ownership, Membership on an entity’s Board of Directors or advisory committees; Enzon Pharmaceuticals: Equity Ownership, Membership on an entity’s Board of Directors or advisory committees.

Topics:
chromatin, dna, gene expression, stem cells, transcription factor, equity, disclosure, genes, human development, advisory committees

Author notes

*

Asterisk with author names denotes non-ASH members.

© 2013 by The American Society of Hematology
2013
Sign in via your Institution