Abstract
We have already reported the construction and evaluation of a self-bioluminescent reporter strain of E. coli with high sensititivity to the nucleoside analogue cytosine arabinoside (Ara-C) the mainstay of treatment in patients with Acute Myeloid Leukaemia (
Blood
, 106
(11), Abstr. 2473; 695a
TABLE 1:
Patient . | Diagnosis . | Clinical Outcome . | Differential Light Output: cytotoxicity test . | Bioluminescent Assay: Ara-C sensitivity . |
---|---|---|---|---|
1 | M0 | No response | 5% | no |
2 | M2 | No Response | 84% | no |
3 | M2 | No Response | 79% | no |
4 | M3 | Remission Death | 91% | no |
5 | M4 | Complete Response | 99% | yes |
6 | M4 | No Response | 62% | no |
Patient . | Diagnosis . | Clinical Outcome . | Differential Light Output: cytotoxicity test . | Bioluminescent Assay: Ara-C sensitivity . |
---|---|---|---|---|
1 | M0 | No response | 5% | no |
2 | M2 | No Response | 84% | no |
3 | M2 | No Response | 79% | no |
4 | M3 | Remission Death | 91% | no |
5 | M4 | Complete Response | 99% | yes |
6 | M4 | No Response | 62% | no |
Author notes
Disclosure: No relevant conflicts of interest to declare.
2007, The American Society of Hematology
2007
This feature is available to Subscribers Only
Sign In or Create an Account Close Modal