Abstract
We have pioneered co-infusion of a low number of T-cell highly depleted mobilized hematopoietic stem cells (MHSC) from a third party donor (TPD) as a tool to increase rates of cord blood transplant (CBT) engraftment and full chimerism in adults with high risk hematologic malignancies (“dual transplant”,
Conclusion: These results consolidate our previous description of the “dual transplant” strategy as an approach that may allow high rates of engraftment, full chimerisms and survival of HLA mismatch CBT of relatively low cell content for adults of a wide age range with haematological malignancies, with the possibility of adding other subpopulations of the same TPD as cell therapy tools.
Supported by Grants from the EC-6th FP (AlloStem IP), Goverments of Spain and CAM, and The Gabrielle Rich Foundation.
Author notes
Disclosure:Research Funding: Supported by Grants from the EC-6th FP (AlloStem IP), Goverments of Spain and CAM, and The Gabrielle Rich Foundation.
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