Abstract
Waldenstrom’s macroglobulinemia is a B-cell disorder characterized by the infiltration of lymphoplasmacytic cells (LPC) in the bone marrow (BM), along with an IgM monoclonal gammopathy. Characteristic of WM is an increased number of mast cells (MC) which are found in association with LPC, and stimulate LPC growth through several TNF-family members including CD40L, APRIL and BLYS (
Ann Oncol
17
:1275
Blood
104
:917A
Blood
2004
; 104
:314b
Author notes
Disclosure:Research Funding: Novartis provided study drug. Off Label Use: Gleevec is not approved for WM.
2007, The American Society of Hematology
2007
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