Abstract
Multiple myeloma (MM) cells present with significant genetic abnormality. This genetic instability is considered responsible for not only development of malignant phenotype but also progression of myeloma as well as development of drug resistance. We have previously demonstrated that MM cell lines have elevated homologous recombination activity that leads to acquisition of new genomic changes over time and is associated with development of drug resistance (
Blood
2004
; 104
: 3409
Author notes
Disclosure: No relevant conflicts of interest to declare.
2007, The American Society of Hematology
2007
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