Abstract
In previous work, we have shown that portal vein infusion of an AAV vector expressing an engineered secreted activated murine factor VIIa (mFVIIa) results in long-term phenotypic correction of mFVIIa and phenotypic correction in hemophilia B mice, as judged by shortening of the prothrombin time (PT) and of the activated partial thromboplastin time (aPTT), and correction of the tail-clip bleeding time (
J Clin Invest
2004
Apr; 113
(7): 1025
–31Author notes
Corresponding author
2005, The American Society of Hematology
2004
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