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Issue Archive

Volume 2, Issue 4
February 27 2018
Issue Cover

Table of Contents

DRUG ADVANCES

Midostaurin: its odyssey from discovery to approval for treating acute myeloid leukemia and advanced systemic mastocytosis
Clinical Trials & Observations
Richard M. Stone,Paul W. Manley,Richard A. Larson,Renaud Capdeville
View Articletitled, Midostaurin: its odyssey from discovery to approval for treating acute myeloid leukemia and advanced systemic mastocytosis
Eltrombopag for use in children with immune thrombocytopenia
Clinical Trials & Observations
Taylor Olmsted Kim,Jenny Despotovic,Michele P. Lambert
View Articletitled, Eltrombopag for use in children with immune thrombocytopenia

CLINICAL TRIALS AND OBSERVATIONS

Targeted next-generation sequencing in blast phase myeloproliferative neoplasms
Clinical Trials & Observations
Terra L. Lasho,Mythri Mudireddy,Christy M. Finke,Curtis A. Hanson,Rhett P. Ketterling,Natasha Szuber,Kebede H. Begna,Mrinal M. Patnaik,Naseema Gangat,Animesh Pardanani,Ayalew Tefferi
View Articletitled, Targeted next-generation sequencing in blast phase myeloproliferative neoplasms
Supplemental data
Combination of the low anticoagulant heparin CX-01 with chemotherapy for the treatment of acute myeloid leukemia
Clinical Trials & Observations
Tibor J. Kovacsovics,Alice Mims,Mohamed E. Salama,Jeremy Pantin,Narayanam Rao,Ken M. Kosak,Peter Ahorukomeye,Martha J. Glenn,Michael W. N. Deininger,Kenneth M. Boucher,Linda M. Bavisotto,Gerardo Gutierrez-Sanchez,Thomas P. Kennedy,Stephen G. Marcus,Paul J. Shami
View Articletitled, Combination of the low anticoagulant heparin CX-01 with chemotherapy for the treatment of acute myeloid leukemia

HEALTH SERVICES AND OUTCOMES

Professional illustration by Patrick Lane, ScEYEnce Studios.

Determinants of hematology-oncology trainees' postfellowship career pathways with a focus on nonmalignant hematology
Ariela L. Marshall,Sarah Jenkins,Joseph Mikhael,Scott D. Gitlin
View Articletitled, Determinants of hematology-oncology trainees' postfellowship career pathways with a focus on nonmalignant hematology
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Human herpesvirus 6 viremia affects T-cell reconstitution after allogeneic hematopoietic stem cell transplantation
Clinical Trials & Observations
Coco de Koning,Rick Admiraal,Stefan Nierkens,Jaap Jan Boelens
View Articletitled, Human herpesvirus 6 viremia affects T-cell reconstitution after allogeneic hematopoietic stem cell transplantation

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Hematopoiesis by iPSC-derived hematopoietic stem cells of aplastic anemia that escape cytotoxic T-cell attack
J. Luis Espinoza,Mahmoud I. Elbadry,Kazuhisa Chonabayashi,Yoshinori Yoshida,Takamasa Katagiri,Kenichi Harada,Noriharu Nakagawa,Yoshitaka Zaimoku,Tatsuya Imi,Hiroyuki Takamatsu,Tatsuhiko Ozawa,Hiroyuki Maruyama,Hassan A. Hassanein,Amal Khalifa A. Noreldin,Katsuto Takenaka,Koichi Akashi,Hiroshi Hamana,Hiroyuki Kishi,Yoshiki Akatsuka,Shinji Nakao
View Articletitled, Hematopoiesis by iPSC-derived hematopoietic stem cells of aplastic anemia that escape cytotoxic T-cell attack
Supplemental data
Dock8 regulates BCR signaling and activation of memory B cells via WASP and CD19
Xiaoyu Sun,Jinzhi Wang,Tao Qin,Yongjie Zhang,Lu Huang,Linlin Niu,Xiaoming Bai,Yukai Jing,Xingtian Xuan,Heather Miller,Yao Zhao,Wenxia Song,Xuemei Tang,Zhiyong Zhang,Xiaodong Zhao,Chaohong Liu
View Articletitled, Dock8 regulates BCR signaling and activation of memory B cells via WASP and CD19
Supplemental data
Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice
Steven D. Schutt,Yongxia Wu,Chih-Hang Anthony Tang,David Bastian,Hung Nguyen,M. Hanief Sofi,MengMeng Zhang,Chen Liu,Kris Helke,Carole Wilson,Lynn M. Schnapp,Juan R. Del Valle,Chih-Chi Andrew Hu,Xue-Zhong Yu
View Articletitled, Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice
Supplemental data

LYMPHOID NEOPLASIA

Hypoxia-inducible KDM3A addiction in multiple myeloma
Sho Ikeda,Akihiro Kitadate,Fumito Abe,Naoto Takahashi,Hiroyuki Tagawa
View Articletitled, Hypoxia-inducible KDM3A addiction in multiple myeloma
Supplemental data

MYELOID NEOPLASIA

Natural killer receptor ligand expression on acute myeloid leukemia impacts survival and relapse after chemotherapy
Sara Mastaglio,Eric Wong,Travis Perera,Jane Ripley,Piers Blombery,Mark J. Smyth,Rachel Koldej,David Ritchie
View Articletitled, Natural killer receptor ligand expression on acute myeloid leukemia impacts survival and relapse after chemotherapy
Supplemental data
Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice
Jacob T. Jackson,Ashley P. Ng,Benjamin J. Shields,Sue Haupt,Ygal Haupt,Matthew P. McCormack
View Articletitled, Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice
Supplemental data

THROMBOSIS AND HEMOSTASIS

FVIII proteins with a modified immunodominant T-cell epitope exhibit reduced immunogenicity and normal FVIII activity
Ruth A. Ettinger,Joseph A. Liberman,Devi Gunasekera,Komal Puranik,Eddie A. James,Arthur R. Thompson,Kathleen P. Pratt
View Articletitled, FVIII proteins with a modified immunodominant T-cell epitope exhibit reduced immunogenicity and normal FVIII activity
Supplemental data

VASCULAR BIOLOGY

Reduced red blood cell deformability in Plasmodium knowlesi malaria
Global Advances
Bridget E. Barber,Bruce Russell,Matthew J. Grigg,Rou Zhang,Timothy William,Amirah Amir,Yee Ling Lau,Mark D. Chatfield,Arjen M. Dondorp,Nicholas M. Anstey,Tsin W. Yeo
View Articletitled, Reduced red blood cell deformability in <em>Plasmodium knowlesi</em> malaria
Supplemental data
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Cardiovascular and genetic determinants of platelet high responsiveness: results from the Gutenberg Health Study
Targeting CD38 with isatuximab and a novel CD38/CD3×CD28 trispecific T-cell engager in older patients with acute myeloid leukemia
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Multimodal mechanisms of pathogenic variants in the signal peptide of FIX leading to hemophilia B
Deletion of pyruvate dehydrogenase kinases reduces susceptibility to deep vein thrombosis in mice

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