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Volume 2, Issue 4

February 27 2018

In this Issue

DRUG ADVANCES
CLINICAL TRIALS AND OBSERVATIONS
HEALTH SERVICES AND OUTCOMES
HEMATOPOIESIS AND STEM CELLS
IMMUNOBIOLOGY AND IMMUNOTHERAPY
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
THROMBOSIS AND HEMOSTASIS
VASCULAR BIOLOGY

DRUG ADVANCES

Midostaurin: its odyssey from discovery to approval for treating acute myeloid leukemia and advanced systemic mastocytosis
Clinical Trials & Observations

Richard M. Stone,Paul W. Manley,Richard A. Larson,Renaud Capdeville

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Eltrombopag for use in children with immune thrombocytopenia
Clinical Trials & Observations

Taylor Olmsted Kim,Jenny Despotovic,Michele P. Lambert

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CLINICAL TRIALS AND OBSERVATIONS

Targeted next-generation sequencing in blast phase myeloproliferative neoplasms
Clinical Trials & Observations

Terra L. Lasho,Mythri Mudireddy,Christy M. Finke,Curtis A. Hanson,Rhett P. Ketterling,Natasha Szuber,Kebede H. Begna,Mrinal M. Patnaik,Naseema Gangat,Animesh Pardanani,Ayalew Tefferi

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Supplemental data

Combination of the low anticoagulant heparin CX-01 with chemotherapy for the treatment of acute myeloid leukemia
Clinical Trials & Observations

Tibor J. Kovacsovics,Alice Mims,Mohamed E. Salama,Jeremy Pantin,Narayanam Rao,Ken M. Kosak,Peter Ahorukomeye,Martha J. Glenn,Michael W. N. Deininger,Kenneth M. Boucher,Linda M. Bavisotto,Gerardo Gutierrez-Sanchez,Thomas P. Kennedy,Stephen G. Marcus,Paul J. Shami

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HEALTH SERVICES AND OUTCOMES

Professional illustration by Patrick Lane, ScEYEnce Studios.

Determinants of hematology-oncology trainees' postfellowship career pathways with a focus on nonmalignant hematology

Ariela L. Marshall,Sarah Jenkins,Joseph Mikhael,Scott D. Gitlin

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Supplemental data

HEMATOPOIESIS AND STEM CELLS

Human herpesvirus 6 viremia affects T-cell reconstitution after allogeneic hematopoietic stem cell transplantation
Clinical Trials & Observations

Coco de Koning,Rick Admiraal,Stefan Nierkens,Jaap Jan Boelens

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IMMUNOBIOLOGY AND IMMUNOTHERAPY

Hematopoiesis by iPSC-derived hematopoietic stem cells of aplastic anemia that escape cytotoxic T-cell attack

J. Luis Espinoza,Mahmoud I. Elbadry,Kazuhisa Chonabayashi,Yoshinori Yoshida,Takamasa Katagiri,Kenichi Harada,Noriharu Nakagawa,Yoshitaka Zaimoku,Tatsuya Imi,Hiroyuki Takamatsu,Tatsuhiko Ozawa,Hiroyuki Maruyama,Hassan A. Hassanein,Amal Khalifa A. Noreldin,Katsuto Takenaka,Koichi Akashi,Hiroshi Hamana,Hiroyuki Kishi,Yoshiki Akatsuka,Shinji Nakao

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Supplemental data

Dock8 regulates BCR signaling and activation of memory B cells via WASP and CD19

Xiaoyu Sun,Jinzhi Wang,Tao Qin,Yongjie Zhang,Lu Huang,Linlin Niu,Xiaoming Bai,Yukai Jing,Xingtian Xuan,Heather Miller,Yao Zhao,Wenxia Song,Xuemei Tang,Zhiyong Zhang,Xiaodong Zhao,Chaohong Liu

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Supplemental data

Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice

Steven D. Schutt,Yongxia Wu,Chih-Hang Anthony Tang,David Bastian,Hung Nguyen,M. Hanief Sofi,MengMeng Zhang,Chen Liu,Kris Helke,Carole Wilson,Lynn M. Schnapp,Juan R. Del Valle,Chih-Chi Andrew Hu,Xue-Zhong Yu

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Supplemental data

LYMPHOID NEOPLASIA

Hypoxia-inducible KDM3A addiction in multiple myeloma

Sho Ikeda,Akihiro Kitadate,Fumito Abe,Naoto Takahashi,Hiroyuki Tagawa

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Supplemental data

MYELOID NEOPLASIA

Natural killer receptor ligand expression on acute myeloid leukemia impacts survival and relapse after chemotherapy

Sara Mastaglio,Eric Wong,Travis Perera,Jane Ripley,Piers Blombery,Mark J. Smyth,Rachel Koldej,David Ritchie

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Supplemental data

Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice

Jacob T. Jackson,Ashley P. Ng,Benjamin J. Shields,Sue Haupt,Ygal Haupt,Matthew P. McCormack

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THROMBOSIS AND HEMOSTASIS

FVIII proteins with a modified immunodominant T-cell epitope exhibit reduced immunogenicity and normal FVIII activity

Ruth A. Ettinger,Joseph A. Liberman,Devi Gunasekera,Komal Puranik,Eddie A. James,Arthur R. Thompson,Kathleen P. Pratt

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VASCULAR BIOLOGY

Reduced red blood cell deformability in Plasmodium knowlesi malaria
Global Advances

Bridget E. Barber,Bruce Russell,Matthew J. Grigg,Rou Zhang,Timothy William,Amirah Amir,Yee Ling Lau,Mark D. Chatfield,Arjen M. Dondorp,Nicholas M. Anstey,Tsin W. Yeo

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Cover Image

Cover Image

COVER FIGURE
The image shows important molecules for thrombopoietin signaling, including the site of eltrombopag binding. See the article by Kim et al.
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Late effects after thymectomy

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Real-world outcomes of infections following tisagenlecleucel in patients with B-cell ALL: a CIBMTR analysis

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Table of Contents

DRUG ADVANCES

Midostaurin: its odyssey from discovery to approval for treating acute myeloid leukemia and advanced systemic mastocytosis
Clinical Trials & Observations

Eltrombopag for use in children with immune thrombocytopenia
Clinical Trials & Observations

CLINICAL TRIALS AND OBSERVATIONS

Targeted next-generation sequencing in blast phase myeloproliferative neoplasms
Clinical Trials & Observations

Combination of the low anticoagulant heparin CX-01 with chemotherapy for the treatment of acute myeloid leukemia
Clinical Trials & Observations

HEALTH SERVICES AND OUTCOMES

Determinants of hematology-oncology trainees' postfellowship career pathways with a focus on nonmalignant hematology

HEMATOPOIESIS AND STEM CELLS

Human herpesvirus 6 viremia affects T-cell reconstitution after allogeneic hematopoietic stem cell transplantation
Clinical Trials & Observations

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Hematopoiesis by iPSC-derived hematopoietic stem cells of aplastic anemia that escape cytotoxic T-cell attack

Dock8 regulates BCR signaling and activation of memory B cells via WASP and CD19

Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice

LYMPHOID NEOPLASIA

Hypoxia-inducible KDM3A addiction in multiple myeloma

MYELOID NEOPLASIA

Natural killer receptor ligand expression on acute myeloid leukemia impacts survival and relapse after chemotherapy

Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice

THROMBOSIS AND HEMOSTASIS

FVIII proteins with a modified immunodominant T-cell epitope exhibit reduced immunogenicity and normal FVIII activity

VASCULAR BIOLOGY

Reduced red blood cell deformability in Plasmodium knowlesi malaria
Global Advances

Email alerts

ASH Publications

American Society of Hematology

Issue Archive

Table of Contents

DRUG ADVANCES

Midostaurin: its odyssey from discovery to approval for treating acute myeloid leukemia and advanced systemic mastocytosis Clinical Trials & Observations

Eltrombopag for use in children with immune thrombocytopenia Clinical Trials & Observations

CLINICAL TRIALS AND OBSERVATIONS

Targeted next-generation sequencing in blast phase myeloproliferative neoplasms Clinical Trials & Observations

Combination of the low anticoagulant heparin CX-01 with chemotherapy for the treatment of acute myeloid leukemia Clinical Trials & Observations

HEALTH SERVICES AND OUTCOMES

HEMATOPOIESIS AND STEM CELLS

Human herpesvirus 6 viremia affects T-cell reconstitution after allogeneic hematopoietic stem cell transplantation Clinical Trials & Observations

IMMUNOBIOLOGY AND IMMUNOTHERAPY

LYMPHOID NEOPLASIA

MYELOID NEOPLASIA

THROMBOSIS AND HEMOSTASIS

VASCULAR BIOLOGY

Reduced red blood cell deformability in Plasmodium knowlesi malaria Global Advances

Cover Image

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

Midostaurin: its odyssey from discovery to approval for treating acute myeloid leukemia and advanced systemic mastocytosis
Clinical Trials & Observations

Eltrombopag for use in children with immune thrombocytopenia
Clinical Trials & Observations

Targeted next-generation sequencing in blast phase myeloproliferative neoplasms
Clinical Trials & Observations

Combination of the low anticoagulant heparin CX-01 with chemotherapy for the treatment of acute myeloid leukemia
Clinical Trials & Observations

Human herpesvirus 6 viremia affects T-cell reconstitution after allogeneic hematopoietic stem cell transplantation
Clinical Trials & Observations

Reduced red blood cell deformability in Plasmodium knowlesi malaria
Global Advances